SH-4-54
|
- $20 - $3142
- Product name: SH-4-54
- CAS: 1456632-40-8
- MF: C29H27F5N2O5S
- MW: 610.59
- EINECS:
- MDL Number:MFCD28143917
- Synonyms:4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-Benzoic Acid SH-4-54;SH-4-54;4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-benzoic acid;Benzoic acid, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-;CS-1773;SH-4-54 USP/EP/BP;SH 4 54,Inhibitor,SH454,inhibit,STAT;SH-4-54, 10 mM in DMSO
57 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- TRC
Package
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM(in1mLDMSO)
- 2.5mg
- 10mM*1mLinDMSO(Solution)
- 1mg
- 2mg
- 10mM*1mLinDMSO
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1G
- 10 mg
- Manufactureraablocks
- Product numberAA001D6M
- Product descriptionSH-4-54 98%
- Packaging1mg
- Price$20
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001D6M
- Product descriptionSH-4-54 98%
- Packaging2mg
- Price$28
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001D6M
- Product descriptionSH-4-54 98%
- Packaging5mg
- Price$44
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001D6M
- Product descriptionSH-4-54 98%
- Packaging10mg
- Price$64
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001D6M
- Product descriptionSH-4-54 98%
- Packaging25mg
- Price$108
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001D6M
- Product descriptionSH-4-54 98%
- Packaging50mg
- Price$183
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001D6M
- Product descriptionSH-4-54 98%
- Packaging100mg
- Price$299
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72378
- Product descriptionSH-4-54 98%
- Packaging100MG
- Price$315
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72378
- Product descriptionSH-4-54 98%
- Packaging5MG
- Price$59
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72378
- Product descriptionSH-4-54 98%
- Packaging25MG
- Price$131
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72378
- Product descriptionSH-4-54 98%
- Packaging1G
- Price$1350
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number2716AH
- Product descriptionSH-4-54
- Packaging250mg
- Price$1262
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2716AH
- Product descriptionSH-4-54
- Packaging5mg
- Price$177
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004689
- Product descriptionSH-4-54 95.00%
- Packaging5MG
- Price$505.7
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4789
- Product descriptionSH-4-54
- Packaging100mg
- Price$759
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB4789
- Product descriptionSH-4-54
- Packaging10mM(in1mLDMSO)
- Price$165
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA001D6M | SH-4-54 98% | 1mg | $20 | 2026-05-28 | Buy |
| aablocks | AA001D6M | SH-4-54 98% | 2mg | $28 | 2026-05-28 | Buy |
| aablocks | AA001D6M | SH-4-54 98% | 5mg | $44 | 2026-05-28 | Buy |
| aablocks | AA001D6M | SH-4-54 98% | 10mg | $64 | 2026-05-28 | Buy |
| aablocks | AA001D6M | SH-4-54 98% | 25mg | $108 | 2026-05-28 | Buy |
| aablocks | AA001D6M | SH-4-54 98% | 50mg | $183 | 2026-05-28 | Buy |
| aablocks | AA001D6M | SH-4-54 98% | 100mg | $299 | 2026-05-28 | Buy |
| ACHEMBLOCK | S72378 | SH-4-54 98% | 100MG | $315 | 2026-05-27 | Buy |
| ACHEMBLOCK | S72378 | SH-4-54 98% | 5MG | $59 | 2026-05-27 | Buy |
| ACHEMBLOCK | S72378 | SH-4-54 98% | 25MG | $131 | 2026-05-27 | Buy |
| ACHEMBLOCK | S72378 | SH-4-54 98% | 1G | $1350 | 2026-05-27 | Buy |
| AK Scientific | 2716AH | SH-4-54 | 250mg | $1262 | 2021-12-16 | Buy |
| AK Scientific | 2716AH | SH-4-54 | 5mg | $177 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004689 | SH-4-54 95.00% | 5MG | $505.7 | 2021-12-16 | Buy |
| ApexBio Technology | B4789 | SH-4-54 | 100mg | $759 | 2026-05-06 | Buy |
| ApexBio Technology | B4789 | SH-4-54 | 10mM(in1mLDMSO) | $165 | 2026-05-06 | Buy |
Properties
Boiling point :717.2±70.0 °C(Predicted)
Density :1.431±0.06 g/cm3(Predicted)
storage temp. :Desiccate at -20°C
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml
form :A crystalline solid
pka :4.29±0.10(Predicted)
color :White to off-white
InChIKey :VFPYGNNOSJWBHF-UHFFFAOYSA-N
SMILES :C(O)(=O)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(C2=C(F)C(F)=C(F)C(F)=C2F)(=O)=O)=O)C=C1
Density :1.431±0.06 g/cm3(Predicted)
storage temp. :Desiccate at -20°C
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml
form :A crystalline solid
pka :4.29±0.10(Predicted)
color :White to off-white
InChIKey :VFPYGNNOSJWBHF-UHFFFAOYSA-N
SMILES :C(O)(=O)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(C2=C(F)C(F)=C(F)C(F)=C2F)(=O)=O)=O)C=C1
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
SH-4-54 is an inhibitor of signal transducer and activator of transcription 3 (STAT3; IC50 = 4.7 μM for STAT3 homodimer DNA binding activity). It selectively inhibits STAT3 homodimer over STAT1 and STAT5 homodimer and STAT3:STAT1 heterodimer DNA binding in EGF-stimulated NIH3T3/hEGFR nuclear extracts containing activated STAT1, STAT3, and STAT5 and decreases STAT3 iNOS, Survivin, and Bcl-2 promoter occupancy in MDA-MB-231 cells. SH-4-54 inhibits growth of glioma, breast, and prostate cancer cell lines that express constitutively active STAT3 (IC50s = 1-7.4, 3.8-4.5, and 5.3-5.8 μM, respectively). In vivo, SH-4-54 (3 mg/kg per day) inhibits tumor growth in the U251MG glioma and MDA-MB-231 breast cancer mouse xenograft models.Related product price
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