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ChemicalBook >> CAS DataBase List >> Sildenafil

Sildenafil

$6 - $2004
Product name: Sildenafil
CAS: 139755-83-2
MF: C22H30N6O4S
MW: 474.58
EINECS:604-158-7
MDL Number:MFCD00867528
Synonyms:SILDENAFIL;7H-Pyrazolo[4,3-d]pyriMidin-7-one, 5-[2-ethoxy-5-[(4-Methyl -1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-Methyl-3-propyl-;Sildenafil solution;5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d] pyrimidin-7-one;5-[2-Ethoxy-5-[(4-methyl-piperazin-1-yl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one;5-(2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one;5-[2-ethoxy-5-(4-Methylpiperazine-1-sulfonyl)phenyl]-1-Methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyriMidin-7-one;1-[[3-(4,7-Dihydro-1-Methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyriMidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-Methylpiperazine

Price62 Properties Safety Information Description

62 prices

Selected condition：

Brand

aablocks
AK Scientific
Ambeed
American Custom Chemicals Corporation
ApexBio Technology
AvaChem
Biosynth
Cayman Chemical
ChemScene
Chemtos
Crysdot
DC Chemicals
Sigma-Aldrich
TRC
Usbiological

Package

50mg
200mg
10mM(in 1mL H2O)
1mg
5mg
10mM*1mLinDMSO
500mg
1mL
2g
2.5mg
250mg
1g
5g
10g
10mg
25MG
100mg
10mM(in1mLH2O)

Manufactureraablocks
Product numberAA001BLD
Product description5-[2-Ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one ≥98%
Packaging50mg
Price$39
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA001BLD
Product description5-[2-Ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 98%
Packaging250mg
Price$74
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA001BLD
Product description5-[2-Ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 98%
Packaging1g
Price$174
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA001BLD
Product description5-[2-Ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 98%
Packaging5g
Price$674
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA001BLD
Product description5-[2-Ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 98%
Packaging10g
Price$1096
Updated2026-05-28
Buy

ManufacturerAK Scientific
Product numberM901
Product descriptionSildenafil 98%(HPLC)
Packaging1g
Price$587
Updated2026-06-04
Buy

ManufacturerAK Scientific
Product numberJ59367
Product descriptionSildenafil 95%
Packaging250mg
Price$187
Updated2026-06-04
Buy

ManufacturerAK Scientific
Product numberM901
Product descriptionSildenafil 98%(HPLC)
Packaging250mg
Price$261
Updated2026-06-04
Buy

ManufacturerAK Scientific
Product numberJ59367
Product descriptionSildenafil 95%
Packaging1g
Price$418
Updated2026-06-04
Buy

ManufacturerAK Scientific
Product numberM901
Product descriptionSildenafil 98%(HPLC)
Packaging50mg
Price$79
Updated2026-06-04
Buy

ManufacturerAK Scientific
Product numberM901
Product descriptionSildenafil
Packaging100mg
Price$144
Updated2021-12-16
Buy

ManufacturerAK Scientific
Product numberJ59367
Product descriptionSildenafil 95%
Packaging50mg
Price$56
Updated2026-06-04
Buy

ManufacturerAmbeed
Product numberA504277
Product description5-(2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 98+%
Packaging1g
Price$69
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA504277
Product description5-(2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 98+%
Packaging10mg
Price$6
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA504277
Product description5-(2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 98+%
Packaging50mg
Price$11
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA504277
Product description5-(2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 98+%
Packaging100mg
Price$16
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA001BLD	5-[2-Ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one ≥98%	50mg	$39	2026-05-28	Buy
aablocks	AA001BLD	5-[2-Ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 98%	250mg	$74	2026-05-28	Buy
aablocks	AA001BLD	5-[2-Ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 98%	1g	$174	2026-05-28	Buy
aablocks	AA001BLD	5-[2-Ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 98%	5g	$674	2026-05-28	Buy
aablocks	AA001BLD	5-[2-Ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 98%	10g	$1096	2026-05-28	Buy
AK Scientific	M901	Sildenafil 98%(HPLC)	1g	$587	2026-06-04	Buy
AK Scientific	J59367	Sildenafil 95%	250mg	$187	2026-06-04	Buy
AK Scientific	M901	Sildenafil 98%(HPLC)	250mg	$261	2026-06-04	Buy
AK Scientific	J59367	Sildenafil 95%	1g	$418	2026-06-04	Buy
AK Scientific	M901	Sildenafil 98%(HPLC)	50mg	$79	2026-06-04	Buy
AK Scientific	M901	Sildenafil	100mg	$144	2021-12-16	Buy
AK Scientific	J59367	Sildenafil 95%	50mg	$56	2026-06-04	Buy
Ambeed	A504277	5-(2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 98+%	1g	$69	2021-12-16	Buy
Ambeed	A504277	5-(2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 98+%	10mg	$6	2021-12-16	Buy
Ambeed	A504277	5-(2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 98+%	50mg	$11	2021-12-16	Buy
Ambeed	A504277	5-(2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 98+%	100mg	$16	2021-12-16	Buy

Next Last

Properties

Melting point :187-189°C
Density :1.39±0.1 g/cm3(Predicted)
Flash point :9℃
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :pKa 8.7 (Uncertain)
color :White to Off-White
Henry's Law Constant :1.4×10¹⁵ mol/(m³Pa) at 25℃, HSDB (2015)
Major Application :pharmaceutical (small molecule)
InChI :1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)
InChIKey :BNRNXUUZRGQAQC-UHFFFAOYSA-N
SMILES :O=C1NC(C2=C(OCC)C=CC(S(=O)(N3CCN(C)CC3)=O)=C2)=NC4=C1N(C)N=C4CCC
CAS DataBase Reference :139755-83-2(CAS DataBase Reference)
EPA Substance Registry System :7H-Pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl- (139755-83-2)

Safety Information

Symbol(GHS):

Signal word:

Danger

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes
H225	Highly Flammable liquid and vapour	Flammable liquids	Category 2	Danger		P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370	Causes damage to organs	Specific target organ toxicity, single exposure	Category 1	Danger		P260, P264, P270, P307+P311, P321,P405, P501

Precautionary statements:

P210	Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.

Description

Sildenafil was launched as Viagra in the US for the treatment of organic orland psychological male erectile dysfunction (ED). It is an orally bioavailable pyrazolopyrimidinone derivative structurally related to zaprinast, with vasodilating and potential anti-inflammatory activities. Upon oral administration, sildenafil selectively targets and inhibits cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), thereby inhibiting the PDE5-mediated degradation of cGMP found in smooth muscle and increasing cGMP availability. This results in prolonged smooth muscle relaxation in the corpus cavernosum of the penis, thereby causing vasodilation, blood engorgement and a prolonged penile erection.

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Sildenafil

Properties

Safety Information

Description

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