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Sildenafil

Indications and Usage Adverse Reactions
Sildenafil
Sildenafil structure
CAS No.
139755-83-2
Chemical Name:
Sildenafil
Synonyms
viagTa;Revatio;UK-92480;Sildefil;SIDANAFIL;SILDENAFIL;Sildenafile;+8617197824028;sildenafil BPC;Sildenafil(Viagra)
CBNumber:
CB2747316
Molecular Formula:
C22H30N6O4S
Formula Weight:
474.58
MOL File:
139755-83-2.mol

Sildenafil Properties

Melting point:
187-189°C
Flash point:
9℃
storage temp. 
Refrigerator
pka
pKa 8.7 (Uncertain)
InChIKey
BNRNXUUZRGQAQC-UHFFFAOYSA-N
CAS DataBase Reference
139755-83-2(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,T,F
Risk Statements  36/37/38-39/23/24/25-23/24/25-11
Safety Statements  22-24/25-36-26-45-36/37-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  1
HS Code  38220090
Hazardous Substances Data 139755-83-2(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Sildenafil price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S-010 Sildenafil solution 1.0mg/mL in methanol, ampule of 1mL, certified reference material 139755-83-2 010-1ml $79.3 2018-11-20 Buy
Cayman Chemical 10008671 Sildenafil ≥98% 139755-83-2 10mg $37 2018-11-19 Buy
Cayman Chemical 10008671 Sildenafil ≥98% 139755-83-2 25mg $65 2018-11-19 Buy
Cayman Chemical 10008671 Sildenafil ≥98% 139755-83-2 50mg $93 2018-11-19 Buy

Sildenafil Chemical Properties,Uses,Production

Indications and Usage

Sildenafil Citrate is an oral drug used to treat male erectile dysfunction and is a 5-phosphodiesterase inhibitor developed by the American Pfizer Pharmaceuticals to originally treat cardiovascular disease that was later discovered to improve patients’ sex lives. Sildenafil Citrate treats erectile dysfunction and was the first clinical oral drug used to specifically target male erectile dysfunction.

Adverse Reactions

Common adverse reactions include headache, dizziness, facial flushing, indigestion, nasal congestion, and sight abnormalities, which may be expressed as difficulty differentiation blue/green colors, light sensitivity, or blurry vision. More severe adverse effects include decreased supine blood pressure and decreased cardiac output. Additionally, clinical research shows that engaging in sexual activity after taking Sildenafil Citrate increases the risk of heart abnormalities, including angina pectoris, dizziness, nausea, and other symptoms, and it may also cause sudden cardiac death.

Description

Sildenafil was launched as Viagra in the US for the treatment of organic orland psychological male erectile dysfunction (ED). Sildenafil can be obtained by functional rearrangement of the corresponding 5-aryl 1,3-dialkyl pyrazolo[4,3- d]pyrimidin-7-one, itself synthesized in a seven-step sequence from a pyrazole- 5-carboxylate. Sildenafil is a potent and selective inhibitor of type V cGMP phosphodiesterases (PDE5) ; IC50 = 3nM on isozymes from human corpus cavernosum tissue. This orally-active therapy is completely new and presents advantages over the classically recommended options such as vacuum constriction devices, drug injection or prosthesis implantation ; for these reasons, this first drug is likely to have a large acceptance fot the treatment of male ED. In experiments with incubated rabbit penile tissue, Sildenafil was shown to cause accumulation of cGMP. By inhibiting the enzyme PDE5, the predominant isozyme in the corpus cavernosum, Sildenafil induces an elevation of levels of second messager cGMP, which is involved in the regulation of vascular tone ; it was suggested that the specific elevation of cGMP due to Sildefanil would mediate an enhancement of nitric oxide-dependent relaxation of corpus cavernosal tissue. Several clinical studies using 10-100 mg Sildenafil have confirmed a good effectiveness and tolerability in healthy males. New trials in women with sexual disfunction have been initiated and positive results could enlarge the potential market of this drug.

Chemical Properties

White Solid

Uses

antiviral

Uses

An orally active selective type 5 cGMP phosphodiesterase inhibitor.

Definition

ChEBI: A pyrazolo[4,3-d]pyrimidin-7-one having a methyl substituent at the 1-position, a propyl substituent at the 3-position and a 2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl group at the 5-position.

brand name

Viagra (Pfizer);Segurex.

Sildenafil Preparation Products And Raw materials

Raw materials

Preparation Products


Sildenafil Suppliers

Global( 219)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 189 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 295 58
Jinan Tenglong Chemical Co.,Ltd
Whatsapp:+8615563263311 Skype:live:smions7080
smions7080@gmail.com CHINA 770 58
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 552 55
Hebei Guanlang Biotechnology Co., Ltd.
+86-0311-66562153 whatsapp +8615203118427
+86-0311-66562153 sales@crovellbio.com CHINA 416 50
Dalian Pinmai Biotechnology Co., Ltd
+86-13230167943
pinmai04@dlpinmai.com CHINA 307 58
Hebei Huanhao Biotechnology Co., Ltd.
86-0311-83975816
86-0311-83975816 grace@hbhuanhao.com CHINA 680 58
Hebei Chisure Biotechnology Co., Ltd.
+8613292893290
+8613292893290 Nancy@SpeedGainpharma.com CHINA 590 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651
breeduan@crovellbio.com CHINA 898 58
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19954 60

View Lastest Price from Sildenafil manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-17 Sildenafil
139755-83-2
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2019-04-16 Sildenafil
139755-83-2
US $1.00 / kg 100g 99% 800 kg hdzhl biotechnology co., ltd
2019-04-11 Sildenafil
139755-83-2
US $1.00 / g 10g 99% 500 Kilogram/Kilograms per Month Cangzhou Wanyou New Material Technology Co.,Ltd

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