Siremadlin
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- $32 - $2500
- Product name: Siremadlin
- CAS: 1448867-41-1
- MF: C26H24Cl2N6O4
- MW: 555.41
- EINECS:
- MDL Number:MFCD30502893
- Synonyms:(6S)-5-(5-chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)-Pyrrolo[3,4-d]imidazol-4(1H)-one;Pyrrolo[3,4-d]imidazol-4(1H)-one, 5-(5-chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)-, (6S)-;Siremadlin (NVP-HDM201);NVP-HDM201;CS-2613;CS-2787;HDM201; HDM 201; HDM-201; NVP-HDM201; NVP-HDM-201; NVP-HDM 201;(S)-5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one
39 prices
Selected condition：
Brand
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Arctom
- Axon Medchem
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Matrix Scientific
Package
- 10mM*1mLinDMSO(Solution)
- 5.00mg
- 10.00mg
- 50.00mg
- 250mg
- 1g
- 10mM*1mLinDMSO
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mg
- 5mg
- 10mg
- 25MG
- 50mg
- 100MG
- 10mM(in1mLDMSO)
- ManufacturerACHEMBLOCK
- Product numberT97260
- Product description(S)-5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one 98%
- Packaging25MG
- Price$310
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberT97260
- Product description(S)-5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one 98%
- Packaging100MG
- Price$760
- Updated2026-05-25
- Buy
- ManufacturerAK Scientific
- Product number1697DV
- Product descriptionSiremadlin
- Packaging10mg
- Price$286
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB8320
- Product descriptionHDM201
- Packaging10mg
- Price$297
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB8320
- Product descriptionHDM201
- Packaging50mg
- Price$869
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB8320
- Product descriptionHDM201
- Packaging1mg
- Price$55
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB8320
- Product descriptionHDM201
- Packaging5mg
- Price$200
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB8320
- Product descriptionHDM201
- Packaging10mM(in1mLDMSO)
- Price$209
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB8320
- Product descriptionHDM201
- Packaging100mg
- Price$1375
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-18658
- Product descriptionSiremadlin 99.65%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$163
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-18658
- Product descriptionSiremadlin 99.65%
- Packaging10mM*1mLinDMSO(Solution)
- Price$163
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-18658
- Product descriptionSiremadlin 99.65%
- Packaging1mg
- Price$63
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-18658
- Product descriptionSiremadlin 99.65%
- Packaging5mg
- Price$133
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-18658
- Product descriptionSiremadlin 99.65%
- Packaging100mg
- Price$981
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-18658
- Product descriptionSiremadlin 99.65%
- Packaging10mg
- Price$230
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-18658
- Product descriptionSiremadlin 99.65%
- Packaging50mg
- Price$654
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ACHEMBLOCK | T97260 | (S)-5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one 98% | 25MG | $310 | 2026-05-25 | Buy |
| ACHEMBLOCK | T97260 | (S)-5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one 98% | 100MG | $760 | 2026-05-25 | Buy |
| AK Scientific | 1697DV | Siremadlin | 10mg | $286 | 2021-12-16 | Buy |
| ApexBio Technology | B8320 | HDM201 | 10mg | $297 | 2026-05-06 | Buy |
| ApexBio Technology | B8320 | HDM201 | 50mg | $869 | 2026-05-06 | Buy |
| ApexBio Technology | B8320 | HDM201 | 1mg | $55 | 2026-05-06 | Buy |
| ApexBio Technology | B8320 | HDM201 | 5mg | $200 | 2026-05-06 | Buy |
| ApexBio Technology | B8320 | HDM201 | 10mM(in1mLDMSO) | $209 | 2026-05-06 | Buy |
| ApexBio Technology | B8320 | HDM201 | 100mg | $1375 | 2026-05-06 | Buy |
| Arctom | HY-18658 | Siremadlin 99.65% | 10mM*1mLinDMSO(Solid+Solvent) | $163 | 2026-05-26 | Buy |
| Arctom | HY-18658 | Siremadlin 99.65% | 10mM*1mLinDMSO(Solution) | $163 | 2026-05-26 | Buy |
| Arctom | HY-18658 | Siremadlin 99.65% | 1mg | $63 | 2026-05-26 | Buy |
| Arctom | HY-18658 | Siremadlin 99.65% | 5mg | $133 | 2026-05-26 | Buy |
| Arctom | HY-18658 | Siremadlin 99.65% | 100mg | $981 | 2026-05-26 | Buy |
| Arctom | HY-18658 | Siremadlin 99.65% | 10mg | $230 | 2026-05-26 | Buy |
| Arctom | HY-18658 | Siremadlin 99.65% | 50mg | $654 | 2026-05-26 | Buy |
Properties
Boiling point :736.5±70.0 °C(Predicted)
Density :1.47±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO : ≥ 56.75 mg/mL (102.18 mM)
form :Solid
pka :1.33±0.29(Predicted)
color :White to off-white
InChIKey :AGBSXNCBIWWLHD-FQEVSTJZSA-N
SMILES :C1(C2=CN=C(OC)N=C2OC)=NC2C(=O)N(C3=CC(Cl)=CN(C)C3=O)[C@@H](C3=CC=C(Cl)C=C3)C=2N1C(C)C
Density :1.47±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO : ≥ 56.75 mg/mL (102.18 mM)
form :Solid
pka :1.33±0.29(Predicted)
color :White to off-white
InChIKey :AGBSXNCBIWWLHD-FQEVSTJZSA-N
SMILES :C1(C2=CN=C(OC)N=C2OC)=NC2C(=O)N(C3=CC(Cl)=CN(C)C3=O)[C@@H](C3=CC=C(Cl)C=C3)C=2N1C(C)C
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
Siremadlin is an oral biologic agent that is a selective inhibitor of the p53-MDM2 interaction and is being investigated for the treatment of patients with myeloid malignancies after showing single agent activity in preclinical studies.
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![(6S)-5-(5-chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)-Pyrrolo[3,4-d]imidazol-4(1H)-one](https://img.chemicalbook.com/ProductImageEN/2019-8/small/5cb209a9-e5a3-43fd-9135-752a720bab90.jpg){kind=small}
