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ChemicalBook >> CAS DataBase List >> Sitravatinib

Sitravatinib

Sitravatinib price.
  • $22 - $1600
  • Product name: Sitravatinib
  • CAS: 1123837-84-2
  • MF: C33H29F2N5O4S
  • MW: 629.68
  • EINECS:
  • MDL Number:MFCD28502181
  • Synonyms:Sitravatinib;N-(3-fluoro-4-((2-(5-(((2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;MGCD-516;MG516;Sitravatinib (MGCD516);CS-2638;1,1-Cyclopropanedicarboxamide, N-[3-fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N'-(4-fluorophenyl)-;RTK,MG-516,PD-1,SCFR,DDR1,inhibit,VEGFR2,MG 516,MGCD 516,MER,immune,TRKA,Cluster of differentiation antigen 135,Cancer,Discoidin Domain Receptor,VEGFR3,Inhibitor,Vascular endothelial growth factor receptor,Trk Receptor,Tropomyosin related kinase receptor,CD135,VEGFR,immunotherapy,Macrophages,c-Kit,DDR2,VEGFR1,Tyrosine,Fms like tyrosine kinase 3,FLT3,Axl,TRKB,Sitravatinib,MGCD-516,KIT,kinase,CD117
Price51 Properties Safety Information Description
51 prices
Selected condition：
Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Biosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
  • Usbiological
Package
  • 10mM(1mLinDMSO)
  • 10mM*1mLinDMSO(Solution)
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 10mM*1mLinDMSO
  • 1mg
  • 5mg
  • 10mg
  • 20mg
  • 25mg
  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 500mg
  • 1g
  • Manufactureraablocks
  • Product numberAA008TMR
  • Product descriptionN-[3-Fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide 98%
  • Packaging1mg
  • Price$22
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA008TMR
  • Product descriptionN-[3-Fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide 98%
  • Packaging5mg
  • Price$35
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA008TMR
  • Product descriptionN-[3-Fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide 98%
  • Packaging10mg
  • Price$52
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA008TMR
  • Product descriptionN-[3-Fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide 98%
  • Packaging25mg
  • Price$98
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA008TMR
  • Product descriptionN-[3-Fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide 98%
  • Packaging50mg
  • Price$157
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA008TMR
  • Product descriptionN-[3-Fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide 98%
  • Packaging100mg
  • Price$250
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA008TMR
  • Product descriptionN-[3-Fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide 98
  • Packaging200mg
  • Price$471
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA008TMR
  • Product descriptionN-[3-Fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide 98
  • Packaging500mg
  • Price$732
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberY228285
  • Product descriptionSitravatinib 97.00%
  • Packaging100MG
  • Price$425
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberY228285
  • Product descriptionSitravatinib 97.00%
  • Packaging25MG
  • Price$165
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number3193DC
  • Product descriptionSitravatinib
  • Packaging5mg
  • Price$151
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number3193DC
  • Product descriptionSitravatinib
  • Packaging10mg
  • Price$205
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4695
  • Product descriptionSitravatinib
  • Packaging10mg
  • Price$100
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4695
  • Product descriptionSitravatinib
  • Packaging5mg
  • Price$64
  • Updated2026-05-06
  • Buy
  • ManufacturerArctom
  • Product numberSLK-S8573
  • Product descriptionSitravatinib (MGCD516) 99.97%
  • Packaging5mg
  • Price$140
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-16961
  • Product descriptionSitravatinib 99.57%
  • Packaging5mg
  • Price$57
  • Updated2026-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA008TMR N-[3-Fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide 98% 1mg $22 2026-05-28 Buy
aablocks AA008TMR N-[3-Fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide 98% 5mg $35 2026-05-28 Buy
aablocks AA008TMR N-[3-Fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide 98% 10mg $52 2026-05-28 Buy
aablocks AA008TMR N-[3-Fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide 98% 25mg $98 2026-05-28 Buy
aablocks AA008TMR N-[3-Fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide 98% 50mg $157 2026-05-28 Buy
aablocks AA008TMR N-[3-Fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide 98% 100mg $250 2026-05-28 Buy
aablocks AA008TMR N-[3-Fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide 98 200mg $471 2026-05-28 Buy
aablocks AA008TMR N-[3-Fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide 98 500mg $732 2026-05-28 Buy
ACHEMBLOCK Y228285 Sitravatinib 97.00% 100MG $425 2026-05-27 Buy
ACHEMBLOCK Y228285 Sitravatinib 97.00% 25MG $165 2026-05-27 Buy
AK Scientific 3193DC Sitravatinib 5mg $151 2021-12-16 Buy
AK Scientific 3193DC Sitravatinib 10mg $205 2021-12-16 Buy
ApexBio Technology A4695 Sitravatinib 10mg $100 2026-05-06 Buy
ApexBio Technology A4695 Sitravatinib 5mg $64 2026-05-06 Buy
Arctom SLK-S8573 Sitravatinib (MGCD516) 99.97% 5mg $140 2026-05-26 Buy
Arctom HY-16961 Sitravatinib 99.57% 5mg $57 2026-05-26 Buy
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Properties

Boiling point :833.5±65.0 °C(Predicted)
Density :1.417±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml), or in Ethanol (up to at least 25 mg/ml)
pka :13.17±0.70(Predicted)
form :solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey :WLAVZAAODLTUSW-UHFFFAOYSA-N
SMILES :C1(C(NC2=CC=C(F)C=C2)=O)(C(NC2=CC=C(OC3C=CN=C4C=C(C5=NC=C(CNCCOC)C=C5)SC4=3)C(F)=C2)=O)CC1

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Sitravatinib is a multi-kinase inhibitor. It inhibits 35 kinases (IC50s = 0.5-5,550 nM) in a panel of 55 receptor tyrosine kinases (RTKs). Sitravatinib reduces proliferation of A-673, LPS141, MPNST, DDLS, and Saos-2 cancer cells (IC50s = 1,750, 340.1, 705.7, 266, and 1,830 nM, respectively) and decreases phosphorylation of insulin-like growth factor 1 receptor (IGF1-R), PDGFRβ, and Akt in these same cells when used at concentrations ranging from 62.5 to 4,000 nM. It decreases tumor growth in LPS141 and MPNST mouse xenograft models when administered at a dose of 15 mg/kg per day.

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Suppliers and manufacturers

TargetMol Chemicals Inc.
Sitravatinib
$47.00
Sitravatinib CAS:1123837-84-2
Zhejiang J&C Biological Technology Co.,Limited
TargetMol Chemicals Inc.
Zibo Hangyu Biotechnology Development Co., Ltd
HANGZHOU LEAP CHEM CO., LTD.
Aladdin Scientific
Amadis Chemical Company Limited Suzhou Meidi Senuo Pharmaceutical Technology Co., Ltd. Dalian Meilun Biotech Co., Ltd. Bide Pharmatech Ltd.