Sitravatinib
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- $50 - $1600
- Product name: Sitravatinib
- CAS: 1123837-84-2
- MF: C33H29F2N5O4S
- MW: 629.68
- EINECS:
- MDL Number:MFCD28502181
- Synonyms:Sitravatinib;N-(3-fluoro-4-((2-(5-(((2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;MGCD-516;MG516;Sitravatinib (MGCD516);CS-2638;1,1-Cyclopropanedicarboxamide, N-[3-fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N'-(4-fluorophenyl)-;RTK,MG-516,PD-1,SCFR,DDR1,inhibit,VEGFR2,MG 516,MGCD 516,MER,immune,TRKA,Cluster of differentiation antigen 135,Cancer,Discoidin Domain Receptor,VEGFR3,Inhibitor,Vascular endothelial growth factor receptor,Trk Receptor,Tropomyosin related kinase receptor,CD135,VEGFR,immunotherapy,Macrophages,c-Kit,DDR2,VEGFR1,Tyrosine,Fms like tyrosine kinase 3,FLT3,Axl,TRKB,Sitravatinib,MGCD-516,KIT,kinase,CD117
50 prices
Selected condition：
Brand
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Arctom
- AvaChem
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- TRC
- Usbiological
Package
- 50mg
- 250mg
- 200mg
- 10mM(1mLinDMSO)
- 10mM*1mLinDMSO
- 1g
- 5mg
- 10mg
- 25MG
- 100MG
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM*1mLinDMSO(Solution)
- ManufacturerACHEMBLOCK
- Product numberY228285
- Product descriptionSitravatinib 97.00%
- Packaging100MG
- Price$425
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228285
- Product descriptionSitravatinib 97.00%
- Packaging25MG
- Price$165
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number3193DC
- Product descriptionSitravatinib
- Packaging5mg
- Price$151
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3193DC
- Product descriptionSitravatinib
- Packaging10mg
- Price$205
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4695
- Product descriptionSitravatinib
- Packaging10mg
- Price$100
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4695
- Product descriptionSitravatinib
- Packaging5mg
- Price$64
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-16961
- Product descriptionSitravatinib 99.57%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$76
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-16961
- Product descriptionSitravatinib 99.57%
- Packaging10mM*1mLinDMSO(Solution)
- Price$79
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-16961
- Product descriptionSitravatinib 99.57%
- Packaging5mg
- Price$57
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-16961
- Product descriptionSitravatinib 99.57%
- Packaging25mg
- Price$162
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S8573
- Product descriptionSitravatinib (MGCD516) 99.97%
- Packaging10mM(1mLinDMSO)
- Price$197
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S8573
- Product descriptionSitravatinib (MGCD516) 99.97%
- Packaging5mg
- Price$140
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-16961
- Product descriptionSitravatinib 99.57%
- Packaging50mg
- Price$257
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S8573
- Product descriptionSitravatinib (MGCD516) 99.97%
- Packaging25mg
- Price$352
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-16961
- Product descriptionSitravatinib 99.57%
- Packaging100mg
- Price$409
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-16961
- Product descriptionSitravatinib 99.57%
- Packaging200mg
- Price$646
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ACHEMBLOCK | Y228285 | Sitravatinib 97.00% | 100MG | $425 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y228285 | Sitravatinib 97.00% | 25MG | $165 | 2026-05-27 | Buy |
| AK Scientific | 3193DC | Sitravatinib | 5mg | $151 | 2021-12-16 | Buy |
| AK Scientific | 3193DC | Sitravatinib | 10mg | $205 | 2021-12-16 | Buy |
| ApexBio Technology | A4695 | Sitravatinib | 10mg | $100 | 2026-05-06 | Buy |
| ApexBio Technology | A4695 | Sitravatinib | 5mg | $64 | 2026-05-06 | Buy |
| Arctom | HY-16961 | Sitravatinib 99.57% | 10mM*1mLinDMSO(Solid+Solvent) | $76 | 2026-05-26 | Buy |
| Arctom | HY-16961 | Sitravatinib 99.57% | 10mM*1mLinDMSO(Solution) | $79 | 2026-05-26 | Buy |
| Arctom | HY-16961 | Sitravatinib 99.57% | 5mg | $57 | 2026-05-26 | Buy |
| Arctom | HY-16961 | Sitravatinib 99.57% | 25mg | $162 | 2026-05-26 | Buy |
| Arctom | SLK-S8573 | Sitravatinib (MGCD516) 99.97% | 10mM(1mLinDMSO) | $197 | 2026-05-26 | Buy |
| Arctom | SLK-S8573 | Sitravatinib (MGCD516) 99.97% | 5mg | $140 | 2026-05-26 | Buy |
| Arctom | HY-16961 | Sitravatinib 99.57% | 50mg | $257 | 2026-05-26 | Buy |
| Arctom | SLK-S8573 | Sitravatinib (MGCD516) 99.97% | 25mg | $352 | 2026-05-26 | Buy |
| Arctom | HY-16961 | Sitravatinib 99.57% | 100mg | $409 | 2026-05-26 | Buy |
| Arctom | HY-16961 | Sitravatinib 99.57% | 200mg | $646 | 2026-05-26 | Buy |
Properties
Boiling point :833.5±65.0 °C(Predicted)
Density :1.417±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml), or in Ethanol (up to at least 25 mg/ml)
pka :13.17±0.70(Predicted)
form :solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey :WLAVZAAODLTUSW-UHFFFAOYSA-N
SMILES :C1(C(NC2=CC=C(F)C=C2)=O)(C(NC2=CC=C(OC3C=CN=C4C=C(C5=NC=C(CNCCOC)C=C5)SC4=3)C(F)=C2)=O)CC1
Density :1.417±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml), or in Ethanol (up to at least 25 mg/ml)
pka :13.17±0.70(Predicted)
form :solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey :WLAVZAAODLTUSW-UHFFFAOYSA-N
SMILES :C1(C(NC2=CC=C(F)C=C2)=O)(C(NC2=CC=C(OC3C=CN=C4C=C(C5=NC=C(CNCCOC)C=C5)SC4=3)C(F)=C2)=O)CC1
Safety Information
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Description
Sitravatinib is a multi-kinase inhibitor. It inhibits 35 kinases (IC50s = 0.5-5,550 nM) in a panel of 55 receptor tyrosine kinases (RTKs). Sitravatinib reduces proliferation of A-673, LPS141, MPNST, DDLS, and Saos-2 cancer cells (IC50s = 1,750, 340.1, 705.7, 266, and 1,830 nM, respectively) and decreases phosphorylation of insulin-like growth factor 1 receptor (IGF1-R), PDGFRβ, and Akt in these same cells when used at concentrations ranging from 62.5 to 4,000 nM. It decreases tumor growth in LPS141 and MPNST mouse xenograft models when administered at a dose of 15 mg/kg per day.More related product prices
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