Syk Inhibitor II
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- $55 - $2806
- Product name: Syk Inhibitor II
- CAS: 726695-51-8
- MF: C14H15F3N6O
- MW: 340.3
- EINECS:
- MDL Number:MFCD12922523
- Synonyms:ATP-competitive,Serotonin Receptor,antigen,inhibit,Spleen tyrosine kinase,Syk Inhibitor II,Anti-allergic,pyrimidine-carboxamide,Inhibitor,Syk,5-HT Receptor,5-hydroxytryptamine Receptor;5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-;2-((2-Aminoethyl)amino)-4-((3-(trifluoromethyl)phenyl)amino)pyrimidine-5-carboxamide;Syk Inhibitor II, 10 mM in DMSO
33 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- Arctom
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
Package
- 10mM*1mLinDMSO(Solution)
- 10mM*1mLinDMSO(Solid+Solvent)
- 500μg
- 1mg
- 5mg
- 10mg
- 25MG
- 50mg
- 100MG
- 250mg
- 1G
- Manufactureraablocks
- Product numberAA01DU7S
- Product description2-((2-Aminoethyl)amino)-4-((3-(trifluoromethyl)phenyl)amino)pyrimidine-5-carboxamide ≥98%
- Packaging1mg
- Price$251
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA01DU7S
- Product description2-((2-Aminoethyl)amino)-4-((3-(trifluoromethyl)phenyl)amino)pyrimidine-5-carboxamide ≥98%
- Packaging5mg
- Price$1048
- Updated2026-05-29
- Buy
- ManufacturerACHEMBLOCK
- Product numberP51704
- Product descriptionSyk Inhibitor II 98%
- Packaging1G
- Price$1650
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberP51704
- Product descriptionSyk Inhibitor II 98%
- Packaging100MG
- Price$350
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberP51704
- Product descriptionSyk Inhibitor II 98%
- Packaging5MG
- Price$55
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberP51704
- Product descriptionSyk Inhibitor II 98%
- Packaging25MG
- Price$130
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number9765CQ
- Product descriptionSykInhibitorII
- Packaging1mg
- Price$351
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA1005343
- Product descriptionSyk Inhibitor II 98%
- Packaging10mg
- Price$194
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA1005343
- Product descriptionSyk Inhibitor II 98%
- Packaging5mg
- Price$113
- Updated2026-06-05
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001405
- Product description2-[(2-AMINOETHYL)AMINO]-4-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO]-5-PYRIMIDINECARBOXAMIDE 95.00%
- Packaging5MG
- Price$505.68
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberHY-112390A
- Product descriptionSykInhibitorII 98.15%
- Packaging100mg
- Price$551
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-112390A
- Product descriptionSykInhibitorII 98.15%
- Packaging10mg
- Price$114
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-112390A
- Product descriptionSykInhibitorII 98.15%
- Packaging5mg
- Price$76
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-112390A
- Product descriptionSykInhibitorII 98.15%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$80
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-112390A
- Product descriptionSykInhibitorII 98.15%
- Packaging10mM*1mLinDMSO(Solution)
- Price$84
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-112390A
- Product descriptionSykInhibitorII 98.15%
- Packaging25mg
- Price$219
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA01DU7S | 2-((2-Aminoethyl)amino)-4-((3-(trifluoromethyl)phenyl)amino)pyrimidine-5-carboxamide ≥98% | 1mg | $251 | 2026-05-29 | Buy |
| aablocks | AA01DU7S | 2-((2-Aminoethyl)amino)-4-((3-(trifluoromethyl)phenyl)amino)pyrimidine-5-carboxamide ≥98% | 5mg | $1048 | 2026-05-29 | Buy |
| ACHEMBLOCK | P51704 | Syk Inhibitor II 98% | 1G | $1650 | 2026-05-27 | Buy |
| ACHEMBLOCK | P51704 | Syk Inhibitor II 98% | 100MG | $350 | 2026-05-27 | Buy |
| ACHEMBLOCK | P51704 | Syk Inhibitor II 98% | 5MG | $55 | 2026-05-27 | Buy |
| ACHEMBLOCK | P51704 | Syk Inhibitor II 98% | 25MG | $130 | 2026-05-27 | Buy |
| AK Scientific | 9765CQ | SykInhibitorII | 1mg | $351 | 2021-12-16 | Buy |
| Ambeed | A1005343 | Syk Inhibitor II 98% | 10mg | $194 | 2026-06-05 | Buy |
| Ambeed | A1005343 | Syk Inhibitor II 98% | 5mg | $113 | 2026-06-05 | Buy |
| American Custom Chemicals Corporation | INB0001405 | 2-[(2-AMINOETHYL)AMINO]-4-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO]-5-PYRIMIDINECARBOXAMIDE 95.00% | 5MG | $505.68 | 2021-12-16 | Buy |
| Arctom | HY-112390A | SykInhibitorII 98.15% | 100mg | $551 | 2026-05-26 | Buy |
| Arctom | HY-112390A | SykInhibitorII 98.15% | 10mg | $114 | 2026-05-26 | Buy |
| Arctom | HY-112390A | SykInhibitorII 98.15% | 5mg | $76 | 2026-05-26 | Buy |
| Arctom | HY-112390A | SykInhibitorII 98.15% | 10mM*1mLinDMSO(Solid+Solvent) | $80 | 2026-05-26 | Buy |
| Arctom | HY-112390A | SykInhibitorII 98.15% | 10mM*1mLinDMSO(Solution) | $84 | 2026-05-26 | Buy |
| Arctom | HY-112390A | SykInhibitorII 98.15% | 25mg | $219 | 2026-05-26 | Buy |
Properties
Melting point :270-272 °C (decomp)(Solv: water (7732-18-5); ethanol (64-17-5))
Boiling point :541.6±60.0 °C(Predicted)
Density :1.455±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 25 mg/ml; DMSO: 15 mg/ml
form :A crystalline solid
pka :14.04±0.50(Predicted)
color :White to off-white
Boiling point :541.6±60.0 °C(Predicted)
Density :1.455±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 25 mg/ml; DMSO: 15 mg/ml
form :A crystalline solid
pka :14.04±0.50(Predicted)
color :White to off-white
Safety Information
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| Signal word: | Warning | |||||||
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Description
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs and mediates downstream signaling. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50 = 41 nM) in an ATP-competitive manner. It is much less potent against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 μM, respectively). Syk inhibitor II has been shown to prevent FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro (IC50 = 460 nM) and to inhibit passive cutaneous anaphylaxis reactions in mice (ID50 = 13.2 mg/kg, s.c.).Related product price
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