Syk Inhibitor II
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- $125 - $1852
- Product name: Syk Inhibitor II
- CAS: 227449-73-2
- MF: C14H16ClF3N6O
- MW: 376.77
- EINECS:
- MDL Number:
- Synonyms:Syk Inhibitor II;Syk Inhibitor II (hydrochloride);2-[(2-Aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-5-pyrimidinecarboxamide Hydrochloride;Syk Inhibitor II dihydrochloride;Syk Inhibitor II dihydrochloride, 10 mM in DMSO;2-(2-aminoethylamino)-4-[3-(trifluoromethyl)anilino]pyrimidine-5-carboxamide,dihydrate,dihydrochloride
14 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Cayman Chemical
- Chemenu
- Sigma-Aldrich
- TRC
Package
- 500μg
- 0.5mg
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- Manufactureraablocks
- Product numberAA01E3RF
- Product descriptionSyk Inhibitor II (hydrochloride)
- Packaging1mg
- Price$126
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E3RF
- Product descriptionSyk Inhibitor II (hydrochloride)
- Packaging2mg
- Price$199
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E3RF
- Product descriptionSyk Inhibitor II (hydrochloride)
- Packaging5mg
- Price$404
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E3RF
- Product descriptionSyk Inhibitor II (hydrochloride)
- Packaging10mg
- Price$566
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E3RF
- Product descriptionSyk Inhibitor II (hydrochloride)
- Packaging25mg
- Price$817
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E3RF
- Product descriptionSyk Inhibitor II (hydrochloride)
- Packaging50mg
- Price$1084
- Updated2026-05-30
- Buy
- ManufacturerACHEMBLOCK
- Product numberY230569
- Product descriptionSyk Inhibitor II hydrochloride 98%
- Packaging25MG
- Price$1195
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY230569
- Product descriptionSyk Inhibitor II hydrochloride 98%
- Packaging5MG
- Price$575
- Updated2026-05-27
- Buy
- ManufacturerCayman Chemical
- Product number18805
- Product descriptionSyk Inhibitor II (hydrochloride) ≥98%
- Packaging5mg
- Price$1048
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number18805
- Product descriptionSyk Inhibitor II (hydrochloride) ≥98%
- Packaging1mg
- Price$251
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number18805
- Product descriptionSyk Inhibitor II (hydrochloride) ≥98%
- Packaging500μg
- Price$132
- Updated2026-04-30
- Buy
- ManufacturerChemenu
- Product numberCM455195
- Product description2-[(2-Aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-5-pyrimidinecarboxamideHydrochloride 95%+
- Packaging10mg
- Price$1852
- Updated2026-05-26
- Buy
- ManufacturerSigma-Aldrich
- Product number574712
- Product descriptionSyk Inhibitor II - CAS 227449-73-2 - Calbiochem
- Packaging1mg
- Price$404
- Updated2023-01-07
- Buy
- ManufacturerTRC
- Product numberS900000
- Product description2-[(2-Aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-5-pyrimidinecarboxamideHydrochloride
- Packaging0.5mg
- Price$125
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA01E3RF | Syk Inhibitor II (hydrochloride) | 1mg | $126 | 2026-05-30 | Buy |
| aablocks | AA01E3RF | Syk Inhibitor II (hydrochloride) | 2mg | $199 | 2026-05-30 | Buy |
| aablocks | AA01E3RF | Syk Inhibitor II (hydrochloride) | 5mg | $404 | 2026-05-30 | Buy |
| aablocks | AA01E3RF | Syk Inhibitor II (hydrochloride) | 10mg | $566 | 2026-05-30 | Buy |
| aablocks | AA01E3RF | Syk Inhibitor II (hydrochloride) | 25mg | $817 | 2026-05-30 | Buy |
| aablocks | AA01E3RF | Syk Inhibitor II (hydrochloride) | 50mg | $1084 | 2026-05-30 | Buy |
| ACHEMBLOCK | Y230569 | Syk Inhibitor II hydrochloride 98% | 25MG | $1195 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y230569 | Syk Inhibitor II hydrochloride 98% | 5MG | $575 | 2026-05-27 | Buy |
| Cayman Chemical | 18805 | Syk Inhibitor II (hydrochloride) ≥98% | 5mg | $1048 | 2026-04-30 | Buy |
| Cayman Chemical | 18805 | Syk Inhibitor II (hydrochloride) ≥98% | 1mg | $251 | 2026-04-30 | Buy |
| Cayman Chemical | 18805 | Syk Inhibitor II (hydrochloride) ≥98% | 500μg | $132 | 2026-04-30 | Buy |
| Chemenu | CM455195 | 2-[(2-Aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-5-pyrimidinecarboxamideHydrochloride 95%+ | 10mg | $1852 | 2026-05-26 | Buy |
| Sigma-Aldrich | 574712 | Syk Inhibitor II - CAS 227449-73-2 - Calbiochem | 1mg | $404 | 2023-01-07 | Buy |
| TRC | S900000 | 2-[(2-Aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-5-pyrimidinecarboxamideHydrochloride | 0.5mg | $125 | 2021-12-16 | Buy |
Properties
storage temp. :Store at -20°C
solubility :DMF: 2 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.3 mg/ml; PBS (pH 7.2): 10 mg/ml
form :A crystalline solid
color :off-white
InChI :1S/C14H15F3N6O.2ClH.2H2O/c15-14(16,17)8-2-1-3-9(6-8)22-12-10(11(19)24)7-21-13(23-12)20-5-4-18;;;;/h1-3,6-7H,4-5,18H2,(H2,19,24)(H2,20,21,22,23);2*1H;2*1H2
InChIKey :LCACSMNPIITJGG-UHFFFAOYSA-N
solubility :DMF: 2 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.3 mg/ml; PBS (pH 7.2): 10 mg/ml
form :A crystalline solid
color :off-white
InChI :1S/C14H15F3N6O.2ClH.2H2O/c15-14(16,17)8-2-1-3-9(6-8)22-12-10(11(19)24)7-21-13(23-12)20-5-4-18;;;;/h1-3,6-7H,4-5,18H2,(H2,19,24)(H2,20,21,22,23);2*1H;2*1H2
InChIKey :LCACSMNPIITJGG-UHFFFAOYSA-N
Safety Information
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Description
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50 = 41 nM) in an ATP-competitive manner. It is much less potent against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 μM, respectively). Syk inhibitor II has been shown to prevent FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro (IC50 = 460 nM) and to inhibit passive cutaneous anaphylaxis reactions in mice (ID50 = 13.2 mg/kg, s.c.).Related product price
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