Syk Inhibitor II
|
- $125 - $1852
- Product name: Syk Inhibitor II
- CAS: 227449-73-2
- MF: C14H16ClF3N6O
- MW: 376.77
- EINECS:
- MDL Number:
- Synonyms:Syk Inhibitor II;Syk Inhibitor II (hydrochloride);2-[(2-Aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-5-pyrimidinecarboxamide Hydrochloride;Syk Inhibitor II dihydrochloride;Syk Inhibitor II dihydrochloride, 10 mM in DMSO;2-(2-aminoethylamino)-4-[3-(trifluoromethyl)anilino]pyrimidine-5-carboxamide,dihydrate,dihydrochloride
14 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Cayman Chemical
- Chemenu
- Sigma-Aldrich
- TRC
Package
- 500μg
- 0.5mg
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- Manufactureraablocks
- Product numberAA01E3RF
- Product descriptionSyk Inhibitor II (hydrochloride)
- Packaging10mg
- Price$566
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E3RF
- Product descriptionSyk Inhibitor II (hydrochloride)
- Packaging25mg
- Price$817
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E3RF
- Product descriptionSyk Inhibitor II (hydrochloride)
- Packaging50mg
- Price$1084
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E3RF
- Product descriptionSyk Inhibitor II (hydrochloride)
- Packaging5mg
- Price$404
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E3RF
- Product descriptionSyk Inhibitor II (hydrochloride)
- Packaging2mg
- Price$199
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01E3RF
- Product descriptionSyk Inhibitor II (hydrochloride)
- Packaging1mg
- Price$126
- Updated2026-05-30
- Buy
- ManufacturerACHEMBLOCK
- Product numberY230569
- Product descriptionSyk Inhibitor II hydrochloride 98%
- Packaging25MG
- Price$1195
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY230569
- Product descriptionSyk Inhibitor II hydrochloride 98%
- Packaging5MG
- Price$575
- Updated2026-05-27
- Buy
- ManufacturerCayman Chemical
- Product number18805
- Product descriptionSyk Inhibitor II (hydrochloride) ≥98%
- Packaging5mg
- Price$1048
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number18805
- Product descriptionSyk Inhibitor II (hydrochloride) ≥98%
- Packaging500μg
- Price$132
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number18805
- Product descriptionSyk Inhibitor II (hydrochloride) ≥98%
- Packaging1mg
- Price$251
- Updated2026-04-30
- Buy
- ManufacturerChemenu
- Product numberCM455195
- Product description2-[(2-Aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-5-pyrimidinecarboxamideHydrochloride 95%+
- Packaging10mg
- Price$1852
- Updated2026-05-26
- Buy
- ManufacturerSigma-Aldrich
- Product number574712
- Product descriptionSyk Inhibitor II - CAS 227449-73-2 - Calbiochem
- Packaging1mg
- Price$404
- Updated2023-01-07
- Buy
- ManufacturerTRC
- Product numberS900000
- Product description2-[(2-Aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-5-pyrimidinecarboxamideHydrochloride
- Packaging0.5mg
- Price$125
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA01E3RF | Syk Inhibitor II (hydrochloride) | 10mg | $566 | 2026-05-30 | Buy |
| aablocks | AA01E3RF | Syk Inhibitor II (hydrochloride) | 25mg | $817 | 2026-05-30 | Buy |
| aablocks | AA01E3RF | Syk Inhibitor II (hydrochloride) | 50mg | $1084 | 2026-05-30 | Buy |
| aablocks | AA01E3RF | Syk Inhibitor II (hydrochloride) | 5mg | $404 | 2026-05-30 | Buy |
| aablocks | AA01E3RF | Syk Inhibitor II (hydrochloride) | 2mg | $199 | 2026-05-30 | Buy |
| aablocks | AA01E3RF | Syk Inhibitor II (hydrochloride) | 1mg | $126 | 2026-05-30 | Buy |
| ACHEMBLOCK | Y230569 | Syk Inhibitor II hydrochloride 98% | 25MG | $1195 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y230569 | Syk Inhibitor II hydrochloride 98% | 5MG | $575 | 2026-05-27 | Buy |
| Cayman Chemical | 18805 | Syk Inhibitor II (hydrochloride) ≥98% | 5mg | $1048 | 2026-04-30 | Buy |
| Cayman Chemical | 18805 | Syk Inhibitor II (hydrochloride) ≥98% | 500μg | $132 | 2026-04-30 | Buy |
| Cayman Chemical | 18805 | Syk Inhibitor II (hydrochloride) ≥98% | 1mg | $251 | 2026-04-30 | Buy |
| Chemenu | CM455195 | 2-[(2-Aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-5-pyrimidinecarboxamideHydrochloride 95%+ | 10mg | $1852 | 2026-05-26 | Buy |
| Sigma-Aldrich | 574712 | Syk Inhibitor II - CAS 227449-73-2 - Calbiochem | 1mg | $404 | 2023-01-07 | Buy |
| TRC | S900000 | 2-[(2-Aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-5-pyrimidinecarboxamideHydrochloride | 0.5mg | $125 | 2021-12-16 | Buy |
Properties
storage temp. :Store at -20°C
solubility :DMF: 2 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.3 mg/ml; PBS (pH 7.2): 10 mg/ml
form :A crystalline solid
color :off-white
InChI :1S/C14H15F3N6O.2ClH.2H2O/c15-14(16,17)8-2-1-3-9(6-8)22-12-10(11(19)24)7-21-13(23-12)20-5-4-18;;;;/h1-3,6-7H,4-5,18H2,(H2,19,24)(H2,20,21,22,23);2*1H;2*1H2
InChIKey :LCACSMNPIITJGG-UHFFFAOYSA-N
solubility :DMF: 2 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.3 mg/ml; PBS (pH 7.2): 10 mg/ml
form :A crystalline solid
color :off-white
InChI :1S/C14H15F3N6O.2ClH.2H2O/c15-14(16,17)8-2-1-3-9(6-8)22-12-10(11(19)24)7-21-13(23-12)20-5-4-18;;;;/h1-3,6-7H,4-5,18H2,(H2,19,24)(H2,20,21,22,23);2*1H;2*1H2
InChIKey :LCACSMNPIITJGG-UHFFFAOYSA-N
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50 = 41 nM) in an ATP-competitive manner. It is much less potent against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 μM, respectively). Syk inhibitor II has been shown to prevent FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro (IC50 = 460 nM) and to inhibit passive cutaneous anaphylaxis reactions in mice (ID50 = 13.2 mg/kg, s.c.).Related product price
-
3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE
$36-1758.49 -
VEGFR2 Kinase Inhibitor II
$94-728 -
269390-69-4
$60-815
Suppliers and manufacturers
Shaanxi Dideu New Materials Co. Ltd
TargetMol Chemicals Inc.
Shanghai EFE Biological Technology Co., Ltd.
Angel Pharmatech, Ltd.
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
cjbscvictory
TargetMol Chemicals Inc.
Shanghai Easy CDMO Co.,Ltd
Santa Cruz Biotechnology Inc
Syk Inhibitor II
CAS:227449-73-2