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ChemicalBook >> CAS DataBase List >> Trelagliptin

Trelagliptin

Trelagliptin price.
  • $49 - $1208.7
  • Product name: Trelagliptin
  • CAS: 865759-25-7
  • MF: C18H20FN5O2
  • MW: 357.38
  • EINECS:1592732-453-0
  • MDL Number:MFCD22572746
  • Synonyms:Trelagliptin(syr472);Benzonitrile, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H) -pyrimidinyl]methyl]-4-fluoro-;Trelagliptin (R)-2-[[6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]methyl]-4-fluorobenzonitrile;(S)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile;Trelagliptin Isomer Impurity;Trelagliptin, >=98%;Trelagliptin free base;Trelagliptin
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Brand

  • AK Scientific
  • ApexBio Technology
  • Ark Pharm
  • Biorbyt Ltd
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC

Package

  • 1mg
  • 2.5mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1000mg
  • ManufacturerAK Scientific
  • Product number2763AH
  • Product descriptionTrelagliptin
  • Packaging10mg
  • Price$166
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3888
  • Product descriptionTrelagliptin
  • Packaging5mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerArk Pharm
  • Product numberP000057192
  • Product descriptionTrelagliptin 98+%
  • Packaging1mg
  • Price$52
  • Updated2021-12-16
  • Buy
  • ManufacturerArk Pharm
  • Product numberP000057192
  • Product descriptionTrelagliptin 98+%
  • Packaging5mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerArk Pharm
  • Product numberP000057192
  • Product descriptionTrelagliptin 98+%
  • Packaging10mg
  • Price$137
  • Updated2021-12-16
  • Buy
  • ManufacturerArk Pharm
  • Product numberP000057192
  • Product descriptionTrelagliptin 98+%
  • Packaging50mg
  • Price$550
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181339
  • Product descriptionTrelagliptin >98%
  • Packaging100mg
  • Price$414.8
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181339
  • Product descriptionTrelagliptin >98%
  • Packaging250mg
  • Price$615.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181339
  • Product descriptionTrelagliptin >98%
  • Packaging1000mg
  • Price$1208.7
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number18504
  • Product descriptionTrelagliptin ≥98%
  • Packaging1mg
  • Price$62
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18504
  • Product descriptionTrelagliptin ≥98%
  • Packaging5mg
  • Price$270
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18504
  • Product descriptionTrelagliptin ≥98%
  • Packaging10mg
  • Price$388
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1041
  • Product descriptionTrelagliptin 99.80%
  • Packaging5mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1041
  • Product descriptionTrelagliptin 99.80%
  • Packaging10mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1041
  • Product descriptionTrelagliptin 99.80%
  • Packaging50mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1041
  • Product descriptionTrelagliptin 99.80%
  • Packaging100mg
  • Price$160
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2763AH Trelagliptin 10mg $166 2021-12-16 Buy
ApexBio Technology A3888 Trelagliptin 5mg $80 2021-12-16 Buy
Ark Pharm P000057192 Trelagliptin 98+% 1mg $52 2021-12-16 Buy
Ark Pharm P000057192 Trelagliptin 98+% 5mg $85 2021-12-16 Buy
Ark Pharm P000057192 Trelagliptin 98+% 10mg $137 2021-12-16 Buy
Ark Pharm P000057192 Trelagliptin 98+% 50mg $550 2021-12-16 Buy
Biorbyt Ltd orb181339 Trelagliptin >98% 100mg $414.8 2021-12-16 Buy
Biorbyt Ltd orb181339 Trelagliptin >98% 250mg $615.4 2021-12-16 Buy
Biorbyt Ltd orb181339 Trelagliptin >98% 1000mg $1208.7 2021-12-16 Buy
Cayman Chemical 18504 Trelagliptin ≥98% 1mg $62 2024-03-01 Buy
Cayman Chemical 18504 Trelagliptin ≥98% 5mg $270 2024-03-01 Buy
Cayman Chemical 18504 Trelagliptin ≥98% 10mg $388 2024-03-01 Buy
ChemScene CS-1041 Trelagliptin 99.80% 5mg $50 2021-12-16 Buy
ChemScene CS-1041 Trelagliptin 99.80% 10mg $80 2021-12-16 Buy
ChemScene CS-1041 Trelagliptin 99.80% 50mg $120 2021-12-16 Buy
ChemScene CS-1041 Trelagliptin 99.80% 100mg $160 2021-12-16 Buy

Properties

Boiling point :519.0±60.0 °C(Predicted)
Density :1.38±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥11.6 mg/mL in DMSO; ≥3.68 mg/mL in EtOH with gentle warming and ultrasonic; ≥93.8 mg/mL in H2O
form :solid
pka :9.88±0.20(Predicted)
InChI :InChI=1S/C18H20FN5O2/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)10-13-7-14(19)5-4-12(13)9-20/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3/t15-/m1/s1
InChIKey :IWYJYHUNXVAVAA-OAHLLOKOSA-N
SMILES :C(#N)C1=CC=C(F)C=C1CN1C(=O)N(C)C(=O)C=C1N1CCC[C@@H](N)C1

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Dipeptidyl peptidase 4 (DPP-4) is an intrinsic membrane glycoprotein that acts as an exopeptidase, cleaving oligopeptides after the second amino acid from the N-terminal end. One of its substrates is glucagon-like peptide 1, an incretin that stimulates insulin biosynthesis and secretion while inhibiting glucagon release in a glucose-dependent manner. Trelagliptin is a pyrimidinedione-based, long-acting inhibitor of DPP-4 (IC50 = 4 nM). It demonstrates >10,000-fold selectivity over other peptidases. Trelagliptin has been used to improve glucose tolerance and postprandial plasma insulin levels in Zucker fa/fa rats. In 2014 this compound underwent phase III clinical trials.