UNC0638
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- $16 - $3515
- Product name: UNC0638
- CAS: 1255580-76-7
- MF: C30H47N5O2
- MW: 509.73
- EINECS:
- MDL Number:
- Synonyms:UNC0638;UNC0638/UNC-0638;2-Cyclohexyl-N-(1-isopropyl-4-piperidinyl)-6-Methoxy-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinaMine;2-Cyclohexyl-6-Methoxy-N-[1-(1-Methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinaMine;UNC0638 2-Cyclohexyl-6-Methoxy-N-[1-(1-Methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinaMine;2-cyclohexyl-6-methoxy-n-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine;CS-565;4-Quinazolinamine, 2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-
70 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Synthonix
- Tocris
- TRC
Package
- 2mg
- 250mg
- 10mM*1mLinDMSO(Solution)
- 10mM(1mLinDMSO)
- 2 mg
- 10
- 1000mg
- 10mM*1mLinDMSO
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 1G
- 10mM(in1mLDMSO)
- Manufactureraablocks
- Product numberAA000NS4
- Product description2-Cyclohexyl-6-Methoxy-N-[1-(1-Methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinaMine 99%
- Packaging1mg
- Price$16
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000NS4
- Product description2-Cyclohexyl-6-Methoxy-N-[1-(1-Methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinaMine 99%
- Packaging5mg
- Price$30
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000NS4
- Product description2-Cyclohexyl-6-Methoxy-N-[1-(1-Methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinaMine 99
- Packaging25mg
- Price$139
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000NS4
- Product description2-Cyclohexyl-6-Methoxy-N-[1-(1-Methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinaMine 99
- Packaging50mg
- Price$236
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000NS4
- Product description2-Cyclohexyl-6-Methoxy-N-[1-(1-Methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinaMine 99
- Packaging100mg
- Price$349
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberM24072
- Product descriptionUNC0638 98%
- Packaging1G
- Price$1295
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberM24072
- Product descriptionUNC0638 98%
- Packaging1G
- Price$1295
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM24072
- Product descriptionUNC0638 98%
- Packaging100MG
- Price$260
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberM24072
- Product descriptionUNC0638 98%
- Packaging100MG
- Price$260
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM24072
- Product descriptionUNC0638 98%
- Packaging5MG
- Price$35
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberM24072
- Product descriptionUNC0638 98%
- Packaging5MG
- Price$35
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM24072
- Product descriptionUNC0638 98%
- Packaging25MG
- Price$85
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM24072
- Product descriptionUNC0638 98%
- Packaging25MG
- Price$85
- Updated2026-05-25
- Buy
- ManufacturerAK Scientific
- Product number3615DG
- Product descriptionUnc-0638
- Packaging1mg
- Price$151
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3615DG
- Product descriptionUnc-0638
- Packaging10mg
- Price$330
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1914
- Product descriptionUNC0638
- Packaging50mg
- Price$350
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA000NS4 | 2-Cyclohexyl-6-Methoxy-N-[1-(1-Methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinaMine 99% | 1mg | $16 | 2026-05-25 | Buy |
| aablocks | AA000NS4 | 2-Cyclohexyl-6-Methoxy-N-[1-(1-Methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinaMine 99% | 5mg | $30 | 2026-05-25 | Buy |
| aablocks | AA000NS4 | 2-Cyclohexyl-6-Methoxy-N-[1-(1-Methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinaMine 99 | 25mg | $139 | 2026-05-25 | Buy |
| aablocks | AA000NS4 | 2-Cyclohexyl-6-Methoxy-N-[1-(1-Methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinaMine 99 | 50mg | $236 | 2026-05-25 | Buy |
| aablocks | AA000NS4 | 2-Cyclohexyl-6-Methoxy-N-[1-(1-Methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinaMine 99 | 100mg | $349 | 2026-05-25 | Buy |
| ACHEMBLOCK | M24072 | UNC0638 98% | 1G | $1295 | 2026-05-25 | Buy |
| ACHEMBLOCK | M24072 | UNC0638 98% | 1G | $1295 | 2026-05-27 | Buy |
| ACHEMBLOCK | M24072 | UNC0638 98% | 100MG | $260 | 2026-05-25 | Buy |
| ACHEMBLOCK | M24072 | UNC0638 98% | 100MG | $260 | 2026-05-27 | Buy |
| ACHEMBLOCK | M24072 | UNC0638 98% | 5MG | $35 | 2026-05-25 | Buy |
| ACHEMBLOCK | M24072 | UNC0638 98% | 5MG | $35 | 2026-05-27 | Buy |
| ACHEMBLOCK | M24072 | UNC0638 98% | 25MG | $85 | 2026-05-27 | Buy |
| ACHEMBLOCK | M24072 | UNC0638 98% | 25MG | $85 | 2026-05-25 | Buy |
| AK Scientific | 3615DG | Unc-0638 | 1mg | $151 | 2021-12-16 | Buy |
| AK Scientific | 3615DG | Unc-0638 | 10mg | $330 | 2021-12-16 | Buy |
| ApexBio Technology | A1914 | UNC0638 | 50mg | $350 | 2021-12-16 | Buy |
Properties
Melting point :93-94℃
Boiling point :610.2±55.0 °C(Predicted)
Density :1.124±0.06 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :≥25.5 mg/mL in DMSO; insoluble in H2O; ≥48.2 mg/mL in EtOH
form :solid
pka :10.07±0.20(Predicted)
color :White to yellow
InChIKey :QOECJCJVIMVJGX-UHFFFAOYSA-N
SMILES :CC(C)N(CC1)CCC1NC2=NC(C3CCCCC3)=NC4=C2C=C(C(OCCCN5CCCC5)=C4)OC
Boiling point :610.2±55.0 °C(Predicted)
Density :1.124±0.06 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :≥25.5 mg/mL in DMSO; insoluble in H2O; ≥48.2 mg/mL in EtOH
form :solid
pka :10.07±0.20(Predicted)
color :White to yellow
InChIKey :QOECJCJVIMVJGX-UHFFFAOYSA-N
SMILES :CC(C)N(CC1)CCC1NC2=NC(C3CCCCC3)=NC4=C2C=C(C(OCCCN5CCCC5)=C4)OC
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | ||||||||||||||
| Hazard statements: |
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| Precautionary statements: |
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Description
The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. UNC0638 is a potent G9a HMTase inhibitor, exhibiting an IC50 value of <15 nM in vitro. UNC0638 also inhibits GLP, a closely-related H3K9 HMTase, with an IC50 value of 19 nM, but is more than 10,000-fold selective against SET7/9 (a H3K4 HMTase), SET8 (a H4K20 HMTase), PRMT3, and SUV39H2. UNC0638 inhibits H3K9 dimethylation in MDA-MB231 cells with an IC50 value of 81 nM and demonstrates favorable separation of functional and toxic effects. See the Structural Genomics Consortium (SGC) website for more information.Related product price
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