VLX1570
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- $35 - $3800
- Product name: VLX1570
- CAS: 1431280-51-1
- MF: C23H17F2N3O6
- MW: 469.4
- EINECS:
- MDL Number:MFCD28502165
- Synonyms:VLX1570;CS-2226;VLX1570 (VLX 1570;4H-Azepin-4-one, 3,5-bis[(4-fluoro-3-nitrophenyl)methylene]hexahydro-1-(1-oxo-2-propen-1-yl)-;(3Z,5Z)-1-Acryloyl-3,5-bis(4-fluoro-3-nitrobenzylidene)azepan-4-one;1-Acryloyl-3,5-bis(4-fluoro-3-nitrobenzylidene)azepan-4-one;VLX1570,Inhibitor,Deubiquitinase,VLX-1570,DUBs,VLX 1570,inhibit;(3E,5E)-1-Acryloyl-3,5-bis(4-fluoro-3-nitrobenzylidene)hexahydro-4H-azepin-4-one
53 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Ambeed
- Arctom
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- TRC
- Usbiological
Package
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mg
- 10mM*1mLinDMSO(Solution)
- 500μg
- 10mM(1mLinDMSO)
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- Manufactureraablocks
- Product numberAA009CL3
- Product descriptionVLX1570 ≥98%
- Packaging1mg
- Price$40
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CL3
- Product descriptionVLX1570 ≥98%
- Packaging5mg
- Price$132
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CL3
- Product descriptionVLX1570 ≥98%
- Packaging10mg
- Price$246
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CL3
- Product descriptionVLX1570 99%
- Packaging25mg
- Price$459
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CL3
- Product descriptionVLX1570
- Packaging50mg
- Price$810
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CL3
- Product descriptionVLX1570
- Packaging100mg
- Price$1116
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228205
- Product descriptionVLX1570 97.00%
- Packaging100MG
- Price$1365
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228205
- Product descriptionVLX1570 97.00%
- Packaging25MG
- Price$535
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228205
- Product descriptionVLX1570 97.00%
- Packaging5MG
- Price$175
- Updated2026-05-27
- Buy
- ManufacturerAmbeed
- Product numberA150004
- Product descriptionVLX1570 98+%
- Packaging25mg
- Price$217
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150004
- Product descriptionVLX1570 98+%
- Packaging10mg
- Price$166
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150004
- Product descriptionVLX1570 98+%
- Packaging100mg
- Price$369
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150004
- Product descriptionVLX1570 98+%
- Packaging250mg
- Price$553
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150004
- Product descriptionVLX1570 98+%
- Packaging50mg
- Price$283
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150004
- Product descriptionVLX1570 98+%
- Packaging5mg
- Price$127
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150004
- Product descriptionVLX1570 98+%
- Packaging1mg
- Price$75
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA009CL3 | VLX1570 ≥98% | 1mg | $40 | 2026-05-28 | Buy |
| aablocks | AA009CL3 | VLX1570 ≥98% | 5mg | $132 | 2026-05-28 | Buy |
| aablocks | AA009CL3 | VLX1570 ≥98% | 10mg | $246 | 2026-05-28 | Buy |
| aablocks | AA009CL3 | VLX1570 99% | 25mg | $459 | 2026-05-28 | Buy |
| aablocks | AA009CL3 | VLX1570 | 50mg | $810 | 2026-05-28 | Buy |
| aablocks | AA009CL3 | VLX1570 | 100mg | $1116 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y228205 | VLX1570 97.00% | 100MG | $1365 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y228205 | VLX1570 97.00% | 25MG | $535 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y228205 | VLX1570 97.00% | 5MG | $175 | 2026-05-27 | Buy |
| Ambeed | A150004 | VLX1570 98+% | 25mg | $217 | 2021-12-16 | Buy |
| Ambeed | A150004 | VLX1570 98+% | 10mg | $166 | 2021-12-16 | Buy |
| Ambeed | A150004 | VLX1570 98+% | 100mg | $369 | 2021-12-16 | Buy |
| Ambeed | A150004 | VLX1570 98+% | 250mg | $553 | 2021-12-16 | Buy |
| Ambeed | A150004 | VLX1570 98+% | 50mg | $283 | 2021-12-16 | Buy |
| Ambeed | A150004 | VLX1570 98+% | 5mg | $127 | 2021-12-16 | Buy |
| Ambeed | A150004 | VLX1570 98+% | 1mg | $75 | 2021-12-16 | Buy |
Properties
Boiling point :722.324±60.00 °C(Press: 760.00 Torr)(predicted)
Density :1.457±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. :Store at -20°C
solubility :DMF:25.0(Max Conc. mg/mL);53.26(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.64(Max Conc. mM)
DMSO:47.0(Max Conc. mg/mL);100.13(Max Conc. mM) form :A crystalline solid
pka :-1.237±0.20(predicted)
color :Light yellow to yellow
Density :1.457±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. :Store at -20°C
solubility :DMF:25.0(Max Conc. mg/mL);53.26(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.64(Max Conc. mM)
DMSO:47.0(Max Conc. mg/mL);100.13(Max Conc. mM) form :A crystalline solid
pka :-1.237±0.20(predicted)
color :Light yellow to yellow
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | |||||||
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Description
VLX1570 is an inhibitor of 19S proteasomal deubiquitinases with IC50 values of 6.4 and 13 μM for deubiquitinase activity in vitro using Ub-rhodamine and Ub-AMC, respectively, as substrates. It is selective for proteasomal deubiquitinases over a panel of deubiquitinases at 20 μM, but inhibits USP5 by greater than 50%, and over a panel of 211 kinases at 10 μM, but inhibits Cdk4 by 77%. VLX1570 binds to and inhibits recombinant ubiquitin-specific protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5) in vitro, and inhibits the USP14 and UCHL5 activity of purified 19S proteasomes when used at a concentration of 50 μM. It inhibits the proliferation of KMS-11, RPMI-8226, OPM-2, and OPM-2-BZR multiple myeloma cells (IC50s = 43, 74, 126, and 191 nM, respectively), as well as induces apoptosis and increases the accumulation of polyubiquitinated proteins. VLX1570 (3 mg/kg per day for 10 days) increases survival and reduces tumor growth in KMS-11-LUC2 and RPMI-8226 mouse xenograft models, respectively.Related product price
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