WP1130
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- $28 - $2839
- Product name: WP1130
- CAS: 856243-80-6
- MF: C19H18BrN3O
- MW: 384.27
- EINECS:604-604-1
- MDL Number:MFCD18839228
- Synonyms:WP1130;(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylbutyl]-2-propenamide;WP1130 ( Degrasyn );(S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide;(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylbutyl]-2-propenamide Degrasyn (WP1130);Degrasyn, >=98%;WP1130;WP 1130;WP-1130;CS-701
66 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 2mg
- 10mM*1mLinDMSO(Solution)
- 2x5mg
- 10mM(in 1mL DMSO)
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM*1mLinDMSO
- 250mg
- 1g
- 1000mg
- 1unit
- 1mg
- 5mg
- 10mg
- 25mg
- EvaluationSample
- 50mg
- 100mg
- 10mM(in1mLDMSO)
- Manufactureraablocks
- Product numberAA00G3NQ
- Product descriptionWP1130 98+%
- Packaging1mg
- Price$28
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G3NQ
- Product descriptionWP1130 98+%
- Packaging5mg
- Price$41
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G3NQ
- Product descriptionWP1130 98+%
- Packaging10mg
- Price$70
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G3NQ
- Product descriptionWP1130 98+%
- Packaging25mg
- Price$151
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G3NQ
- Product descriptionWP1130
- Packaging50mg
- Price$292
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G3NQ
- Product descriptionWP1130 ≥98%
- Packaging100mg
- Price$548
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberX212150
- Product descriptionDegrasyn (WP1130) 97%
- Packaging100MG
- Price$635
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberX212150
- Product descriptionDegrasyn (WP1130) 97%
- Packaging25MG
- Price$235
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3551-M005
- Product descriptionWP1130 ≥95%
- Packaging5mg
- Price$90
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3551-M001
- Product descriptionWP1130 ≥95%
- Packaging1mg
- Price$30
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product numberX7509
- Product description(S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide
- Packaging5mg
- Price$174
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7509
- Product description(S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide
- Packaging50mg
- Price$694
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7509
- Product description(S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide
- Packaging25mg
- Price$415
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7509
- Product description(S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide
- Packaging10mg
- Price$233
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000970
- Product description(2E)-3-(6-BROMO-2-PYRIDINYL)-2-CYANO-N-[(1S)-1-PHENYLBUTYL]-2-PROPENAMIDE 99.00%
- Packaging5MG
- Price$257.4
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8323
- Product descriptionWP1130
- Packaging50mg
- Price$437
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00G3NQ | WP1130 98+% | 1mg | $28 | 2026-05-28 | Buy |
| aablocks | AA00G3NQ | WP1130 98+% | 5mg | $41 | 2026-05-28 | Buy |
| aablocks | AA00G3NQ | WP1130 98+% | 10mg | $70 | 2026-05-28 | Buy |
| aablocks | AA00G3NQ | WP1130 98+% | 25mg | $151 | 2026-05-28 | Buy |
| aablocks | AA00G3NQ | WP1130 | 50mg | $292 | 2026-05-28 | Buy |
| aablocks | AA00G3NQ | WP1130 ≥98% | 100mg | $548 | 2026-05-28 | Buy |
| ACHEMBLOCK | X212150 | Degrasyn (WP1130) 97% | 100MG | $635 | 2026-05-27 | Buy |
| ACHEMBLOCK | X212150 | Degrasyn (WP1130) 97% | 25MG | $235 | 2026-05-27 | Buy |
| Adipogen Life Sciences | AG-CR1-3551-M005 | WP1130 ≥95% | 5mg | $90 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-3551-M001 | WP1130 ≥95% | 1mg | $30 | 2026-05-06 | Buy |
| AK Scientific | X7509 | (S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide | 5mg | $174 | 2021-12-16 | Buy |
| AK Scientific | X7509 | (S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide | 50mg | $694 | 2021-12-16 | Buy |
| AK Scientific | X7509 | (S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide | 25mg | $415 | 2021-12-16 | Buy |
| AK Scientific | X7509 | (S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide | 10mg | $233 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000970 | (2E)-3-(6-BROMO-2-PYRIDINYL)-2-CYANO-N-[(1S)-1-PHENYLBUTYL]-2-PROPENAMIDE 99.00% | 5MG | $257.4 | 2021-12-16 | Buy |
| ApexBio Technology | A8323 | WP1130 | 50mg | $437 | 2026-05-06 | Buy |
Properties
Density :1.358
storage temp. :-20°
solubility :Soluble in DMSO (up to 45 mg/ml), or in Ethanol (up to 25 mg/ml).
form :solid
color :Yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey :LIDOPKHSVQTSJY-VMEIHUARSA-N
SMILES :Brc1nc(ccc1)\C=C(\C(=O)N[C@@H](CCC)c2ccccc2)/C#N
storage temp. :-20°
solubility :Soluble in DMSO (up to 45 mg/ml), or in Ethanol (up to 25 mg/ml).
form :solid
color :Yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey :LIDOPKHSVQTSJY-VMEIHUARSA-N
SMILES :Brc1nc(ccc1)\C=C(\C(=O)N[C@@H](CCC)c2ccccc2)/C#N
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
Protein ubiquitination is a dynamic process that can be reversed by deubiquitinating enzymes (DUBs) that remove ubiquitin from proteins, sparing them from degradation by the proteasome. The DUBs have been divided into two subgroups: ubiquitin-specific proteases (USPs) and ubiquitin-specific COOH-terminal hydrolases (UCHs). Recent evidence suggests that several DUBs are activated in tumor cells and many contribute to a transformed phenotype. WP1130 is a second-generation tyrphostin derivative that inhibits the deubiquitinase activity of USP9x, USP5, USP14, and UCH37. At 5 μM, WP1130-mediated inhibition of tumor-activated DUBs induces a rapid accumulation of protein-ubiquitin conjugates, resulting in the formation of aggresomes and apoptosis in a variety of tumor cells. Through this mechanism, WP1130 has been shown to downregulate the antiapoptotic proteins Bcr/Abl and Jak2 and to upregulate the proapoptotic proteins MCL-1 and p53.Related product price
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