VU0483605
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- $48 - $942
- Product name: VU0483605
- CAS: 1623101-11-0
- MF: C20H10Cl3N3O3
- MW: 446.67
- EINECS:
- MDL Number:MFCD29770792
- Synonyms:VU0483605;2-Chloro-N-[3-chloro-4-(4-chloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)phenyl]nicotinamide;3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide;3-Chloro-N-[3-chloro-4-(4-chloro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-2-pyridinecarboxamide;2-Pyridinecarboxamide, 3-chloro-N-[3-chloro-4-(4-chloro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-;3-chloro-N-[3-chloro-4-(4-chloro-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)phenyl]pyridine-2-carboxamide;3-chloro-N-[3-chloro-4-(4-chloro-1,3-dioxoisoindol-2-yl)phenyl]pyridine-2-carboxamide;Inhibitor,inhibit,VU0483605,Metabotropic glutamate receptors,allosteric modulator,brain penetrant,metabotropic glutamate,VU 0483605,mGluR,VU-0483605
27 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Cayman Chemical
- Chemenu
- Crysdot
- TRC
Package
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- Manufactureraablocks
- Product numberAA00AT7M
- Product description3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide
- Packaging2mg
- Price$48
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00AT7M
- Product description3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide
- Packaging5mg
- Price$67
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00AT7M
- Product description3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide
- Packaging10mg
- Price$99
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00AT7M
- Product description3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide
- Packaging50mg
- Price$259
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00AT7M
- Product description3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide
- Packaging25mg
- Price$175
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00AT7M
- Product description3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide
- Packaging100mg
- Price$379
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY227179
- Product descriptionVU0483605 97.00%
- Packaging50MG
- Price$355
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY227179
- Product descriptionVU0483605 97.00%
- Packaging10MG
- Price$115
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberSYN5042
- Product descriptionVU0483605
- Packaging10mg
- Price$175
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN5042
- Product descriptionVU0483605
- Packaging50mg
- Price$585
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC5611
- Product descriptionVU0483605
- Packaging10mg
- Price$171
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC5611
- Product descriptionVU0483605
- Packaging10mg
- Price$154
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberC5611
- Product descriptionVU0483605
- Packaging5mg
- Price$90
- Updated2026-05-06
- Buy
- ManufacturerCayman Chemical
- Product number16941
- Product descriptionVU0483605 ≥98%
- Packaging5mg
- Price$96
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16941
- Product descriptionVU0483605 ≥98%
- Packaging1mg
- Price$49
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16941
- Product descriptionVU0483605 ≥98%
- Packaging1mg
- Price$54
- Updated2026-04-30
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00AT7M | 3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide | 2mg | $48 | 2026-05-28 | Buy |
| aablocks | AA00AT7M | 3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide | 5mg | $67 | 2026-05-28 | Buy |
| aablocks | AA00AT7M | 3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide | 10mg | $99 | 2026-05-28 | Buy |
| aablocks | AA00AT7M | 3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide | 50mg | $259 | 2026-05-28 | Buy |
| aablocks | AA00AT7M | 3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide | 25mg | $175 | 2026-05-28 | Buy |
| aablocks | AA00AT7M | 3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide | 100mg | $379 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y227179 | VU0483605 97.00% | 50MG | $355 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y227179 | VU0483605 97.00% | 10MG | $115 | 2026-05-27 | Buy |
| AK Scientific | SYN5042 | VU0483605 | 10mg | $175 | 2021-12-16 | Buy |
| AK Scientific | SYN5042 | VU0483605 | 50mg | $585 | 2021-12-16 | Buy |
| ApexBio Technology | C5611 | VU0483605 | 10mg | $171 | 2021-12-16 | Buy |
| ApexBio Technology | C5611 | VU0483605 | 10mg | $154 | 2026-05-06 | Buy |
| ApexBio Technology | C5611 | VU0483605 | 5mg | $90 | 2026-05-06 | Buy |
| Cayman Chemical | 16941 | VU0483605 ≥98% | 5mg | $96 | 2024-03-01 | Buy |
| Cayman Chemical | 16941 | VU0483605 ≥98% | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 16941 | VU0483605 ≥98% | 1mg | $54 | 2026-04-30 | Buy |
Properties
Density :1.625±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤20mg/ml in DMSO;20mg/ml in dimethyl formamide
form :crystalline solid
pka :9.39±0.70(Predicted)
color :Light yellow to orange
InChI :InChI=1S/C20H10Cl3N3O3/c21-12-4-1-3-11-16(12)20(29)26(19(11)28)15-7-6-10(9-14(15)23)25-18(27)17-13(22)5-2-8-24-17/h1-9H,(H,25,27)
InChIKey :HJQXPBKPTGWZCF-UHFFFAOYSA-N
SMILES :C1(C(NC2=CC=C(N3C(=O)C4=C(C3=O)C=CC=C4Cl)C(Cl)=C2)=O)=NC=CC=C1Cl
storage temp. :Store at -20°C
solubility :≤20mg/ml in DMSO;20mg/ml in dimethyl formamide
form :crystalline solid
pka :9.39±0.70(Predicted)
color :Light yellow to orange
InChI :InChI=1S/C20H10Cl3N3O3/c21-12-4-1-3-11-16(12)20(29)26(19(11)28)15-7-6-10(9-14(15)23)25-18(27)17-13(22)5-2-8-24-17/h1-9H,(H,25,27)
InChIKey :HJQXPBKPTGWZCF-UHFFFAOYSA-N
SMILES :C1(C(NC2=CC=C(N3C(=O)C4=C(C3=O)C=CC=C4Cl)C(Cl)=C2)=O)=NC=CC=C1Cl
Safety Information
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Description
Glutamate, the major excitatory neurotransmitter in the CNS, activates eight known subtypes of metabotropic glutamate receptors (mGluRs). Highly selective modulators designed to act at allosteric sites on certain mGluR subtypes are being developed to preferentially regulate subtype-specific, glutamate-induced receptor activation. VU0483605 is a selective positive allosteric modulator (PAM) of mGluR1, displaying EC50 values of 0.39 and 0.36 μM at human and rat receptors, respectively, and no activity as a mGlu4 PAM (EC50 >10 μM). It has been shown to potentiate a response to glutamate in wild-type cell lines stably expressing mGlu1 and to partially restore the reduction in glutamate-mediated calcium signaling in a mutant cell model of schizophrenia.More related product prices
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