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ChemicalBook >> CAS DataBase List >> WIKI4

WIKI4

WIKI4 price.
  • $72 - $1400
  • Product name: WIKI4
  • CAS: 838818-26-1
  • MF: C29H23N5O3S
  • MW: 521.59
  • EINECS:
  • MDL Number:MFCD05885187
  • Synonyms:WIKI4;2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz[de]isoquinoline-1,3(2H)-dione;WIKI;2-(3-((4-(4-Methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)propyl)-1H-benzo[de]iso;1H-?Benz[de]?isoquinoline-?1,?3(2H)?-?dione, 2-?[3-?[[4-?(4-?methoxyphenyl)?-?5-?(4-?pyridinyl)?-?4H-?1,?2,?4-?triazol-?3-?yl]?thio]?propyl]?-;CS-2099;CS-1491;2-(3-(4-(4-methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-ylthio)propyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
Price23 Properties Safety Information Description
23 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 10
  • 5MG
  • 5
  • 10mg
  • 25
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberSYN5447
  • Product descriptionWIKI4
  • Packaging10mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0004717
  • Product description2-[3-[[4-(4-METHOXYPHENYL)-5-(4-PYRIDINYL)-4H-1,2,4-TRIAZOL-3-YL]THIO]PROPYL]-1H-BENZ[DE]ISOQUINOLINE-1,3(2H)-DIONE 95.00%
  • Packaging5MG
  • Price$501.28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4531
  • Product descriptionWIKI4
  • Packaging10mg
  • Price$97
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4531
  • Product descriptionWIKI4
  • Packaging50mg
  • Price$314
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number14057
  • Product descriptionWIKI4 ≥98%
  • Packaging5mg
  • Price$93
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14057
  • Product descriptionWIKI4 ≥98%
  • Packaging10mg
  • Price$166
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14057
  • Product descriptionWIKI4 ≥98%
  • Packaging25mg
  • Price$388
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14057
  • Product descriptionWIKI4 ≥98%
  • Packaging50mg
  • Price$728
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4319
  • Product descriptionWIKI4 99.77%
  • Packaging5mg
  • Price$72
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4319
  • Product descriptionWIKI4 99.77%
  • Packaging10mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4319
  • Product descriptionWIKI4 99.77%
  • Packaging25mg
  • Price$216
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4319
  • Product descriptionWIKI4 99.77%
  • Packaging50mg
  • Price$372
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31000676
  • Product descriptionWIKI4 98+%
  • Packaging50mg
  • Price$339
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC7533
  • Product descriptionwiki4 >98%
  • Packaging100mg
  • Price$400
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC7533
  • Product descriptionwiki4 >98%
  • Packaging250mg
  • Price$750
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC7533
  • Product descriptionwiki4 >98%
  • Packaging1g
  • Price$1400
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific SYN5447 WIKI4 10mg $160 2021-12-16 Buy
American Custom Chemicals Corporation INB0004717 2-[3-[[4-(4-METHOXYPHENYL)-5-(4-PYRIDINYL)-4H-1,2,4-TRIAZOL-3-YL]THIO]PROPYL]-1H-BENZ[DE]ISOQUINOLINE-1,3(2H)-DIONE 95.00% 5MG $501.28 2021-12-16 Buy
ApexBio Technology A4531 WIKI4 10mg $97 2021-12-16 Buy
ApexBio Technology A4531 WIKI4 50mg $314 2021-12-16 Buy
Cayman Chemical 14057 WIKI4 ≥98% 5mg $93 2024-03-01 Buy
Cayman Chemical 14057 WIKI4 ≥98% 10mg $166 2024-03-01 Buy
Cayman Chemical 14057 WIKI4 ≥98% 25mg $388 2024-03-01 Buy
Cayman Chemical 14057 WIKI4 ≥98% 50mg $728 2024-03-01 Buy
ChemScene CS-4319 WIKI4 99.77% 5mg $72 2021-12-16 Buy
ChemScene CS-4319 WIKI4 99.77% 10mg $110 2021-12-16 Buy
ChemScene CS-4319 WIKI4 99.77% 25mg $216 2021-12-16 Buy
ChemScene CS-4319 WIKI4 99.77% 50mg $372 2021-12-16 Buy
Crysdot CD31000676 WIKI4 98+% 50mg $339 2021-12-16 Buy
DC Chemicals DC7533 wiki4 >98% 100mg $400 2021-12-16 Buy
DC Chemicals DC7533 wiki4 >98% 250mg $750 2021-12-16 Buy
DC Chemicals DC7533 wiki4 >98% 1g $1400 2021-12-16 Buy
Next Last

Properties

Boiling point :783.1±70.0 °C(Predicted)
Density :1.37±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble10mg/mL, clear (warmed)
pka :1.70±0.10(Predicted)
form :powder
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Tankyrases (TNKS) cleave NAD+ to produce nicotinamide and ADP-ribose, which is then covalently attached to an acceptor protein in the process known as poly(ADP-ribosyl)ation. WIKI4 is a potent and selective inhibitor of TNKS1 and TNKS2 (IC50s = 26 and 15 nM, respectively). It has little or no effect on related polymerases or transferases at 10 μM. Through its effects on TNKS2, WIKI4 prevents AXIN ubiquitinylation and degradation, blocking signaling through the Wnt/β-catenin pathway. WIKI4 inhibits the expression of β-catenin target genes and cellular responses to Wnt/β-catenin signaling in both cancer cell lines and embryonic stem cells.

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