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WIKI4

WIKI4 structure

CAS No.: 838818-26-1

Chemical Name:: WIKI4

Synonyms: WIKI;WIKI4;CS-1491;CS-2099;WIKI4 ，S7490;WIKI4 USP/EP/BP;WIKI4, 10 mM in DMSO;Tankyrase1/2 Inhibitor V, WIKI4;WIKI4, Wnt/ beta catenin inhibitor;PARP,poly ADP ribose polymerase,inhibit,Inhibitor,Beta catenin,WIKI-4,β-catenin,WIKI 4,WIKI4

CBNumber:: CB22731164

Molecular Formula:: C29H23N5O3S

Molecular Weight:: 521.59

MDL Number:: MFCD05885187

MOL File:: 838818-26-1.mol

MSDS File:: SDS

Last updated:2025-12-03 18:03:33

Product description	Number	Pack Size	Price
WIKI4 ≥98% (HPLC)	SML0760	5mg	$113
WIKI4 ≥98%	14057	5mg	$93
WIKI4 ≥98%	14057	10mg	$166
WIKI4 ≥98%	14057	25mg	$388
WIKI4 ≥98%	14057	50mg	$728
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WIKI4 Properties

Boiling point	783.1±70.0 °C(Predicted)
Density	1.37±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO: soluble10mg/mL, clear (warmed)
pka	1.70±0.10(Predicted)
form	powder
color	white to beige
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P403+P233-P405-P501
WGK Germany	3

WIKI4 price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0760	WIKI4 ≥98% (HPLC)	838818-26-1	5mg	$113	2022-05-15	Buy
Cayman Chemical	14057	WIKI4 ≥98%	838818-26-1	5mg	$93	2024-03-01	Buy
Cayman Chemical	14057	WIKI4 ≥98%	838818-26-1	10mg	$166	2024-03-01	Buy
Cayman Chemical	14057	WIKI4 ≥98%	838818-26-1	25mg	$388	2024-03-01	Buy
Cayman Chemical	14057	WIKI4 ≥98%	838818-26-1	50mg	$728	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML0760	5mg	$113	Buy
14057	5mg	$93	Buy
14057	10mg	$166	Buy
14057	25mg	$388	Buy
14057	50mg	$728	Buy

WIKI4 Chemical Properties,Uses,Production

Description

Tankyrases (TNKS) cleave NAD⁺ to produce nicotinamide and ADP-ribose, which is then covalently attached to an acceptor protein in the process known as poly(ADP-ribosyl)ation. WIKI4 is a potent and selective inhibitor of TNKS1 and TNKS2 (IC₅₀s = 26 and 15 nM, respectively). It has little or no effect on related polymerases or transferases at 10 μM. Through its effects on TNKS2, WIKI4 prevents AXIN ubiquitinylation and degradation, blocking signaling through the Wnt/β-catenin pathway. WIKI4 inhibits the expression of β-catenin target genes and cellular responses to Wnt/β-catenin signaling in both cancer cell lines and embryonic stem cells.

Uses

WIKI4 is a novel Tankyrase inhibitor. It leads to inhibition of Wnt/?-catenin signaling.

IC 50

TNKS2: 26 nM (IC₅₀)

storage

-20°C

References

[1] RICHARD G JAMES. WIKI4, a novel inhibitor of tankyrase and Wnt/?-catenin signaling.[J]. PLoS ONE, 2012: e50457. DOI: 10.1371/journal.pone.0050457
[2] TEEMU HAIKARAINEN. Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4.[J]. PLoS ONE, 2013: e65404. DOI: 10.1371/journal.pone.0065404

WIKI4 Preparation Products And Raw materials

Raw materials

Preparation Products

WIKI4 Suppliers

Global( 99)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32435	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30229	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	20284	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39035	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	8509	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58

View Lastest Price from WIKI4 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-12-05	WIKI4 838818-26-1	US $34.00-97.00 / mg		99.6%	10g	TargetMol Chemicals Inc.

WIKI4
838818-26-1
US $34.00-97.00 / mg
99.6%
TargetMol Chemicals Inc.

WIKI4 Spectrum

WIKI4(838818-26-1)¹HNMR

838818-26-1(WIKI4)Related Search:

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Lapatinib Ditosylate

1of2

WIKI4 2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz[de]isoquinoline-1,3(2H)-dione WIKI 2-(3-((4-(4-Methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)propyl)-1H-benzo[de]iso 1H-?Benz[de]?isoquinoline-?1,?3(2H)?-?dione, 2-?[3-?[[4-?(4-?methoxyphenyl)?-?5-?(4-?pyridinyl)?-?4H-?1,?2,?4-?triazol-?3-?yl]?thio]?propyl]?- CS-2099 CS-1491 2-(3-(4-(4-methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-ylthio)propyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione WIKI4 USP/EP/BP PARP,poly ADP ribose polymerase,inhibit,Inhibitor,Beta catenin,WIKI-4,β-catenin,WIKI 4,WIKI4 WIKI4, Wnt/ beta catenin inhibitor WIKI4, 10 mM in DMSO Tankyrase1/2 Inhibitor V, WIKI4 WIKI4 ，S7490 838818-26-1 Inhibitors