Wnt-C59
|
- $20 - $6980
- Product name: Wnt-C59
- CAS: 1243243-89-1
- MF: C25H21N3O
- MW: 379.45
- EINECS:-0
- MDL Number:MFCD22201167
- Synonyms:Wnt-C59;2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetaMide;C59;Wnt-C59 (C59);4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide;4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide Wnt-c59;Wnt-C59, >=98%;WNT-C59 (C59);WNT C59;C59
79 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Apolloscientific
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- J&W Pharmlab
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 2mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM(in 1mL DMSO)
- 10mM(in1mLDMSO)
- 50
- 1mg
- 10mM*1mLinDMSO(Solution)
- 10mM*1mLinDMSO
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 1.00g
- 1000mg
- 1G
- 2000mg
- 5000mg
- 5g
- Manufactureraablocks
- Product numberAA000LRJ
- Product descriptionWnt-C59 98%
- Packaging1mg
- Price$20
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000LRJ
- Product descriptionWnt-C59 ≥98%
- Packaging5mg
- Price$33
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000LRJ
- Product descriptionWnt-C59 98%
- Packaging10mg
- Price$57
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000LRJ
- Product descriptionWnt-C59 ≥98%
- Packaging25mg
- Price$123
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000LRJ
- Product descriptionWnt-C59
- Packaging50mg
- Price$188
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000LRJ
- Product descriptionWnt-C59
- Packaging100mg
- Price$308
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000LRJ
- Product descriptionWnt-C59 95%
- Packaging250mg
- Price$613
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product number10253
- Product descriptionWNTC59 98%
- Packaging1G
- Price$950
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10253
- Product descriptionWNTC59 98%
- Packaging100MG
- Price$250
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10253
- Product descriptionWNTC59 98%
- Packaging25MG
- Price$100
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10253
- Product descriptionWNTC59 98%
- Packaging5MG
- Price$50
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number2142AH
- Product description2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide
- Packaging10mg
- Price$193
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8685
- Product descriptionWnt-C59
- Packaging10mM(in 1mL DMSO)
- Price$180
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8685
- Product descriptionWnt-C59
- Packaging50mg
- Price$309
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8685
- Product descriptionWnt-C59
- Packaging5mg
- Price$66
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8685
- Product descriptionWnt-C59
- Packaging10mM(in1mLDMSO)
- Price$77
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA000LRJ | Wnt-C59 98% | 1mg | $20 | 2026-05-25 | Buy |
| aablocks | AA000LRJ | Wnt-C59 ≥98% | 5mg | $33 | 2026-05-25 | Buy |
| aablocks | AA000LRJ | Wnt-C59 98% | 10mg | $57 | 2026-05-25 | Buy |
| aablocks | AA000LRJ | Wnt-C59 ≥98% | 25mg | $123 | 2026-05-25 | Buy |
| aablocks | AA000LRJ | Wnt-C59 | 50mg | $188 | 2026-05-25 | Buy |
| aablocks | AA000LRJ | Wnt-C59 | 100mg | $308 | 2026-05-25 | Buy |
| aablocks | AA000LRJ | Wnt-C59 95% | 250mg | $613 | 2026-05-25 | Buy |
| ACHEMBLOCK | 10253 | WNTC59 98% | 1G | $950 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10253 | WNTC59 98% | 100MG | $250 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10253 | WNTC59 98% | 25MG | $100 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10253 | WNTC59 98% | 5MG | $50 | 2026-05-27 | Buy |
| AK Scientific | 2142AH | 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide | 10mg | $193 | 2021-12-16 | Buy |
| ApexBio Technology | A8685 | Wnt-C59 | 10mM(in 1mL DMSO) | $180 | 2021-12-16 | Buy |
| ApexBio Technology | A8685 | Wnt-C59 | 50mg | $309 | 2026-05-06 | Buy |
| ApexBio Technology | A8685 | Wnt-C59 | 5mg | $66 | 2026-05-06 | Buy |
| ApexBio Technology | A8685 | Wnt-C59 | 10mM(in1mLDMSO) | $77 | 2026-05-06 | Buy |
Properties
Melting point :>159°C (dec.)
Boiling point :628.3±55.0 °C(Predicted)
Density :1.198±0.06 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :Soluble in DMSO (up to 7 mg/ml) or in Ethanol (up to 6 mg/mL)
form :Off-white powder
pka :13.78±0.70(Predicted)
color :Tan
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChI :InChI=1S/C25H21N3O/c1-18-15-22(12-14-27-18)20-6-4-19(5-7-20)16-25(29)28-24-10-8-21(9-11-24)23-3-2-13-26-17-23/h2-15,17H,16H2,1H3,(H,28,29)
InChIKey :KHZOJCQBHJUJFY-UHFFFAOYSA-N
SMILES :C1(CC(NC2=CC=C(C3=CC=CN=C3)C=C2)=O)=CC=C(C2C=CN=C(C)C=2)C=C1
Boiling point :628.3±55.0 °C(Predicted)
Density :1.198±0.06 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :Soluble in DMSO (up to 7 mg/ml) or in Ethanol (up to 6 mg/mL)
form :Off-white powder
pka :13.78±0.70(Predicted)
color :Tan
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChI :InChI=1S/C25H21N3O/c1-18-15-22(12-14-27-18)20-6-4-19(5-7-20)16-25(29)28-24-10-8-21(9-11-24)23-3-2-13-26-17-23/h2-15,17H,16H2,1H3,(H,28,29)
InChIKey :KHZOJCQBHJUJFY-UHFFFAOYSA-N
SMILES :C1(CC(NC2=CC=C(C3=CC=CN=C3)C=C2)=O)=CC=C(C2C=CN=C(C)C=2)C=C1
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins. This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer. Wnt-C59 is a potent inhibitor of PORCN, as measured by prevention of Wnt3A activation (IC50 = 74 pM). As palmitoylation of Wnt is required for its secretion, Wnt-C59 completely blocks Wnt3A secretion into culture media. Wnt-C59 prevents activation of all evaluated Wnt family members. This compound is effective in vivo as well as in vitro. Whether given by intravenous (2.5 mg/kg) or oral administration (5 mg/kg), Wnt-C59 displays a half-life in blood of approximately 1.94 hours, and remains greater than 10-fold above the in vitro IC50 concentration for at least 16 hours after a single oral dose. It blocks the progression of both basal-like and triple-negative breast cancers while downregulating Wnt/β-catenin pathway target genes in mice.More related product prices
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Suppliers and manufacturers
Dideu Industries Group Limited
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NANJING YINGWEN BIOTECHNOLOGY CO LTD
