YS121
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- $55 - $914
- Product name: YS121
- CAS: 916482-17-2
- MF: C20H26ClN3O2S
- MW: 407.96
- EINECS:
- MDL Number:MFCD18382121
- Synonyms:YS121;HVJBWTVMRIOTEL-UHFFFAOYSA-N;YS121 Exclusive;Octanoic acid, 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-
6 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Cayman Chemical
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 5mg(solution)
- ManufacturerAK Scientific
- Product number1614DC
- Product description2-[4-Chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]sulfanyloctanoicacid
- Packaging10mg
- Price$564
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4930
- Product descriptionYS-121
- Packaging5mg(solution)
- Price$269
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13665
- Product descriptionYS-121 ≥98%
- Packaging1mg
- Price$55
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13665
- Product descriptionYS-121 ≥98%
- Packaging5mg
- Price$236
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13665
- Product descriptionYS-121 ≥98%
- Packaging10mg
- Price$420
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13665
- Product descriptionYS-121 ≥98%
- Packaging25mg
- Price$914
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 1614DC | 2-[4-Chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]sulfanyloctanoicacid | 10mg | $564 | 2021-12-16 | Buy |
| ApexBio Technology | C4930 | YS-121 | 5mg(solution) | $269 | 2021-12-16 | Buy |
| Cayman Chemical | 13665 | YS-121 ≥98% | 1mg | $55 | 2024-03-01 | Buy |
| Cayman Chemical | 13665 | YS-121 ≥98% | 5mg | $236 | 2024-03-01 | Buy |
| Cayman Chemical | 13665 | YS-121 ≥98% | 10mg | $420 | 2024-03-01 | Buy |
| Cayman Chemical | 13665 | YS-121 ≥98% | 25mg | $914 | 2024-03-01 | Buy |
Properties
Boiling point :557.4±50.0 °C(Predicted)
Density :1.25±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
pka :3.04±0.21(Predicted)
form :solution in acetate.
color :White to off-white
Density :1.25±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
pka :3.04±0.21(Predicted)
form :solution in acetate.
color :White to off-white
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | |||||||
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Description
Microsomal prostaglandin E2 synthase-1 (mPGES-1), with cyclooxygenase-2 (COX-2), synthesizes PGE2, which is directly involved in signaling during inflammation, fever, and pain. 5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs), which are pro-inflammatory mediators. YS-121 is a dual inhibitor of mPGES-1 (IC50 = 3.9 μM) and 5-LO (IC50 = 4.1 μM). It effectively inhibits PGE2 and LT synthesis in both cell free and intact cell assays. Moreover, YS-121 (1.5 mg/kg, intraperitoneal) reduced pleural levels of PGE2 and LTB4 while blocking exudate formation and leukocyte infiltration in carrageenan-induced rat pleurisy. YS-121 has minor effects on COX-1 and COX-2, inhibiting these enzymes 24.8% and 38%, respectively, at 10 μM.Related product price
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Suppliers and manufacturers
ShangHai Caerulum Pharma Discovery Co., Ltd.
Shanghai Beckham Medical Technology Co., Ltd
Shanghai Chaolan Chemical Technology Center
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
MedBioPharmaceutical Technology Inc
TargetMol Chemicals Inc.
Shanghai Yifei Biotechnology Co. , Ltd.
https://hanhongsci.com/
RD International Technology Co., Limited
