YS121
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- $55 - $914
- Product name: YS121
- CAS: 916482-17-2
- MF: C20H26ClN3O2S
- MW: 407.96
- EINECS:
- MDL Number:MFCD18382121
- Synonyms:YS121;HVJBWTVMRIOTEL-UHFFFAOYSA-N;YS121 Exclusive;Octanoic acid, 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-
6 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Cayman Chemical
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 5mg(solution)
- ManufacturerAK Scientific
- Product number1614DC
- Product description2-[4-Chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]sulfanyloctanoicacid
- Packaging10mg
- Price$564
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4930
- Product descriptionYS-121
- Packaging5mg(solution)
- Price$269
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13665
- Product descriptionYS-121 ≥98%
- Packaging1mg
- Price$55
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13665
- Product descriptionYS-121 ≥98%
- Packaging5mg
- Price$236
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13665
- Product descriptionYS-121 ≥98%
- Packaging10mg
- Price$420
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13665
- Product descriptionYS-121 ≥98%
- Packaging25mg
- Price$914
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 1614DC | 2-[4-Chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]sulfanyloctanoicacid | 10mg | $564 | 2021-12-16 | Buy |
| ApexBio Technology | C4930 | YS-121 | 5mg(solution) | $269 | 2021-12-16 | Buy |
| Cayman Chemical | 13665 | YS-121 ≥98% | 1mg | $55 | 2024-03-01 | Buy |
| Cayman Chemical | 13665 | YS-121 ≥98% | 5mg | $236 | 2024-03-01 | Buy |
| Cayman Chemical | 13665 | YS-121 ≥98% | 10mg | $420 | 2024-03-01 | Buy |
| Cayman Chemical | 13665 | YS-121 ≥98% | 25mg | $914 | 2024-03-01 | Buy |
Properties
Boiling point :557.4±50.0 °C(Predicted)
Density :1.25±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
pka :3.04±0.21(Predicted)
form :solution in acetate.
Density :1.25±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
pka :3.04±0.21(Predicted)
form :solution in acetate.
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | |||||||
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Description
Microsomal prostaglandin E2 synthase-1 (mPGES-1), with cyclooxygenase-2 (COX-2), synthesizes PGE2, which is directly involved in signaling during inflammation, fever, and pain. 5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs), which are pro-inflammatory mediators. YS-121 is a dual inhibitor of mPGES-1 (IC50 = 3.9 μM) and 5-LO (IC50 = 4.1 μM). It effectively inhibits PGE2 and LT synthesis in both cell free and intact cell assays. Moreover, YS-121 (1.5 mg/kg, intraperitoneal) reduced pleural levels of PGE2 and LTB4 while blocking exudate formation and leukocyte infiltration in carrageenan-induced rat pleurisy. YS-121 has minor effects on COX-1 and COX-2, inhibiting these enzymes 24.8% and 38%, respectively, at 10 μM.Related product price
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