Z-Guggulsterone
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- $44 - $4900
- Product name: Z-Guggulsterone
- CAS: 39025-23-5
- MF: C21H28O2
- MW: 312.45
- EINECS:
- MDL Number:MFCD01310757
- Synonyms:4,17(20)-(CIS)-PREGNADIEN-3,16-DIONE;GUGULSTERONE;GUGGULESTERONE Z;GUGGULSTERONE Z;GUGGULSTERONE (Z FORM);CIS-4,17(20)-PREGNADIENE-3,16-DIONE;CIS GUGGULSTERONE;PREGNA-4,17(20)-DIENE-3,16-DIONE
50 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AHH
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Cayman Chemical
- ChemScene
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 5MG
- 10
- 1mg
- 10mg
- 20mg
- 25mg
- 50MG
- 100mg
- 250mg
- 50
- 1g
- Manufactureraablocks
- Product numberAA00C09W
- Product descriptionZ-Guggulsterone ≥95%
- Packaging1mg
- Price$49
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C09W
- Product descriptionZ-Guggulsterone 98%
- Packaging10mg
- Price$60
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C09W
- Product descriptionZ-Guggulsterone 98%
- Packaging25mg
- Price$80
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C09W
- Product descriptionZ-Guggulsterone 98%
- Packaging100mg
- Price$100
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C09W
- Product descriptionZ-Guggulsterone 98%
- Packaging250mg
- Price$145
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C09W
- Product descriptionZ-Guggulsterone 98%
- Packaging1g
- Price$300
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberZ238362
- Product description(Z)-Guggulsterone 98%
- Packaging1G
- Price$210
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberZ238362
- Product description(Z)-Guggulsterone 98%
- Packaging250MG
- Price$145
- Updated2026-05-27
- Buy
- ManufacturerAHH
- Product numberMT-52228
- Product descriptionGugulsterone 98%
- Packaging1g
- Price$810
- Updated2021-12-16
- Buy
- ManufacturerAHH
- Product numberMT-52228
- Product descriptionGugulsterone 97%
- Packaging1g
- Price$810
- Updated2026-05-25
- Buy
- ManufacturerAHH
- Product numberMT-52228
- Product descriptionGugulsterone 97%
- Packaging1g
- Price$810
- Updated2026-05-26
- Buy
- ManufacturerAK Scientific
- Product number3280BB
- Product descriptionGuggulsterone
- Packaging25mg
- Price$317
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0002874
- Product descriptionGUGGULSTERONE Z 95.00%
- Packaging5MG
- Price$660.66
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0002874
- Product descriptionGUGGULSTERONE Z 95.00%
- Packaging10MG
- Price$698.54
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0002874
- Product descriptionGUGGULSTERONE Z 95.00%
- Packaging50MG
- Price$1055.09
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7431
- Product descriptionZ-Guggulsterone
- Packaging50mg
- Price$888
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00C09W | Z-Guggulsterone ≥95% | 1mg | $49 | 2026-05-28 | Buy |
| aablocks | AA00C09W | Z-Guggulsterone 98% | 10mg | $60 | 2026-05-28 | Buy |
| aablocks | AA00C09W | Z-Guggulsterone 98% | 25mg | $80 | 2026-05-28 | Buy |
| aablocks | AA00C09W | Z-Guggulsterone 98% | 100mg | $100 | 2026-05-28 | Buy |
| aablocks | AA00C09W | Z-Guggulsterone 98% | 250mg | $145 | 2026-05-28 | Buy |
| aablocks | AA00C09W | Z-Guggulsterone 98% | 1g | $300 | 2026-05-28 | Buy |
| ACHEMBLOCK | Z238362 | (Z)-Guggulsterone 98% | 1G | $210 | 2026-05-27 | Buy |
| ACHEMBLOCK | Z238362 | (Z)-Guggulsterone 98% | 250MG | $145 | 2026-05-27 | Buy |
| AHH | MT-52228 | Gugulsterone 98% | 1g | $810 | 2021-12-16 | Buy |
| AHH | MT-52228 | Gugulsterone 97% | 1g | $810 | 2026-05-25 | Buy |
| AHH | MT-52228 | Gugulsterone 97% | 1g | $810 | 2026-05-26 | Buy |
| AK Scientific | 3280BB | Guggulsterone | 25mg | $317 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002874 | GUGGULSTERONE Z 95.00% | 5MG | $660.66 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002874 | GUGGULSTERONE Z 95.00% | 10MG | $698.54 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002874 | GUGGULSTERONE Z 95.00% | 50MG | $1055.09 | 2021-12-16 | Buy |
| ApexBio Technology | B7431 | Z-Guggulsterone | 50mg | $888 | 2021-12-16 | Buy |
Properties
Melting point :188-190°
alpha :D26 -61° (c = 1 in chloroform)
Boiling point :463.3±45.0 °C(Predicted)
Density :1.10±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 5 mg/mL
form :powder
color :light yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Major Application :forensics and toxicology
veterinary InChI :InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4+/t15-,17+,18+,20+,21-/m1/s1
InChIKey :WDXRGPWQVHZTQJ-OSJVMJFVSA-N
SMILES :C1(=O)C=C2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)/C(=C/C)/C(=O)C3)CC2
LogP :3.650 (est)
alpha :D26 -61° (c = 1 in chloroform)
Boiling point :463.3±45.0 °C(Predicted)
Density :1.10±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 5 mg/mL
form :powder
color :light yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Major Application :forensics and toxicology
veterinary InChI :InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4+/t15-,17+,18+,20+,21-/m1/s1
InChIKey :WDXRGPWQVHZTQJ-OSJVMJFVSA-N
SMILES :C1(=O)C=C2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)/C(=C/C)/C(=O)C3)CC2
LogP :3.650 (est)
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism. They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress. Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hyperlipidemia, and atherosclerosis. Guggulsterone, derived from resin of the guggul tree, is a competitive antagonist of FXR both in vitro and in vivo. The trans stereoisomer of guggulsterone, (Z)-guggulsterone, decreases chenodeoxycholic acid (CDCA)-induced FXR activation with an IC50 value of 17 μM. By inhibiting CDCA-induced transactivation of FXR, guggulsterone lowers low-density lipoprotein cholesterol and triglyceride levels in rodents fed a high cholesterol diet. While both cis and trans stereoisomers have been shown to directly decrease hepatic cholesterol, the Z isomer is the most studied. (Z)-Guggulsterone demonstrates antitumor-promoting effects inhibiting both constitutive and interleukin-6-induced STAT3 activation in human multiple myeloma cells and suppressing the VEGF-VEGF/R2-Akt signaling axis in DU145 human prostate cancer cells.Related product price
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