γ-Secretase Inhibitor XXI
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- $90 - $3244
- Product name: γ-Secretase Inhibitor XXI
- CAS: 209986-17-4
- MF: C27H24F2N4O3
- MW: 490.5
- EINECS:-0
- MDL Number:
- Synonyms:N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide;CoMpound E (secretase inhibitor);DuPont E;g-Secretase Inhibitor XXI;γ-Secretase Inhibitor BZ;γ-Secretase Inhibitor XXI;(S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S,Z)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide;(S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide
35 prices
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Brand
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- AvaChem
- Axon Medchem
- Biosynth
- Cayman Chemical
- ChemScene
- CSNpharm
- Sigma-Aldrich
- Thermo Scientific Chemicals
- Usbiological
Package
- 250μg
- 250ug
- 500μg
- 0.5mg
- 1mg
- 2mg
- 5MG
- 10mg
- 25MG
- 50mg
- 100MG
- ManufacturerACHEMBLOCK
- Product numberT101586
- Product description(S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide 98%
- Packaging5MG
- Price$510
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberT101586
- Product description(S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide 98%
- Packaging25MG
- Price$1630
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberT101586
- Product description(S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide 98%
- Packaging100MG
- Price$2975
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0081-M005
- Product descriptionCompound E ≥98%(HPLC)
- Packaging5mg
- Price$650
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0081-C250
- Product descriptionCompound E ≥98%(HPLC)
- Packaging250μg
- Price$90
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0081-M001
- Product descriptionCompound E ≥98%(HPLC)
- Packaging1mg
- Price$190
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product number6731CS
- Product descriptiongamma-SecretaseInhibitorXXI
- Packaging5mg
- Price$725
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA1145654
- Product descriptionCompound E 98%
- Packaging5mg
- Price$553
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number7228
- Product descriptionCompound E
- Packaging5mg
- Price$450
- Updated2026-05-22
- Buy
- ManufacturerAvaChem
- Product number7228
- Product descriptionCompound E
- Packaging1mg
- Price$120
- Updated2026-05-22
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1487
- Product descriptionγ-Secretase Inhibitor BZ 99%
- Packaging1mg
- Price$99
- Updated2026-05-19
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1487
- Product descriptionγ-Secretase Inhibitor BZ 99%
- Packaging5mg
- Price$253
- Updated2026-05-19
- Buy
- ManufacturerBiosynth
- Product numberFD103782
- Product descriptionCompound E (secretase inhibitor)
- Packaging0.5mg
- Price$324.5
- Updated2026-06-04
- Buy
- ManufacturerBiosynth
- Product numberFD103782
- Product descriptionCompound E (secretase inhibitor)
- Packaging10mg
- Price$2076.8
- Updated2026-06-04
- Buy
- ManufacturerBiosynth
- Product numberFD103782
- Product descriptionCompound E (secretase inhibitor)
- Packaging1mg
- Price$519.2
- Updated2026-06-04
- Buy
- ManufacturerBiosynth
- Product numberFD103782
- Product descriptionCompound E (secretase inhibitor)
- Packaging5mg
- Price$1168.2
- Updated2026-06-04
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ACHEMBLOCK | T101586 | (S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide 98% | 5MG | $510 | 2026-05-27 | Buy |
| ACHEMBLOCK | T101586 | (S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide 98% | 25MG | $1630 | 2026-05-27 | Buy |
| ACHEMBLOCK | T101586 | (S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide 98% | 100MG | $2975 | 2026-05-27 | Buy |
| Adipogen Life Sciences | AG-CR1-0081-M005 | Compound E ≥98%(HPLC) | 5mg | $650 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-0081-C250 | Compound E ≥98%(HPLC) | 250μg | $90 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-0081-M001 | Compound E ≥98%(HPLC) | 1mg | $190 | 2026-05-06 | Buy |
| AK Scientific | 6731CS | gamma-SecretaseInhibitorXXI | 5mg | $725 | 2021-12-16 | Buy |
| Ambeed | A1145654 | Compound E 98% | 5mg | $553 | 2021-12-16 | Buy |
| AvaChem | 7228 | Compound E | 5mg | $450 | 2026-05-22 | Buy |
| AvaChem | 7228 | Compound E | 1mg | $120 | 2026-05-22 | Buy |
| Axon Medchem | Axon1487 | γ-Secretase Inhibitor BZ 99% | 1mg | $99 | 2026-05-19 | Buy |
| Axon Medchem | Axon1487 | γ-Secretase Inhibitor BZ 99% | 5mg | $253 | 2026-05-19 | Buy |
| Biosynth | FD103782 | Compound E (secretase inhibitor) | 0.5mg | $324.5 | 2026-06-04 | Buy |
| Biosynth | FD103782 | Compound E (secretase inhibitor) | 10mg | $2076.8 | 2026-06-04 | Buy |
| Biosynth | FD103782 | Compound E (secretase inhibitor) | 1mg | $519.2 | 2026-06-04 | Buy |
| Biosynth | FD103782 | Compound E (secretase inhibitor) | 5mg | $1168.2 | 2026-06-04 | Buy |
Properties
Boiling point :778.6±60.0 °C(Predicted)
Density :1.31
storage temp. := -70C
solubility :Soluble in DMSO
form :Liquid
pka :12.54±0.40(Predicted)
color :White to off-white
Sensitive :Light Sensitive
InChIKey :JNGZXGGOCLZBFB-YPHZTSLFSA-N
SMILES :Fc1cc(cc(c1)CC(=O)N[C@@H](C)C(=O)NC2N=C(c4c(cccc4)N(C2=O)C)c3ccccc3)F
Density :1.31
storage temp. := -70C
solubility :Soluble in DMSO
form :Liquid
pka :12.54±0.40(Predicted)
color :White to off-white
Sensitive :Light Sensitive
InChIKey :JNGZXGGOCLZBFB-YPHZTSLFSA-N
SMILES :Fc1cc(cc(c1)CC(=O)N[C@@H](C)C(=O)NC2N=C(c4c(cccc4)N(C2=O)C)c3ccccc3)F
Safety Information
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Description
γ-Secretase is a multimeric aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. Two well-known substrates are the carboxyl-terminal fragments (CTFs) of the receptor Notch, which has key roles in development, and that of amyloid precursor protein (APP), which is important in Alzheimer’s disease. Compound E is a potent, cell-permeable, and selective inhibitor of γ-secretase, blocking the cleavage of both APP and Notch CTFs with IC50 values of ~0.3 nM. Compound E induces neuronal differentiation, impairs ovarian folliculogenesis, and suppresses thymocyte development by preventing Notch activation by γ-secretase.Related product price
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