| | 20537-88-6 Basic information More.. |
| Product Name: | Amifostine | | Synonyms: | γphos;Fosteamine;2-(3-Aminopropyl)aminoethyl phosphorothioate, WR2721;Ethiotas;S-2-[(3-Aminopropyl)amino]ethanethiol dihydrogen phosphate ester;Amifostine,2-(3-Aminopropyl)aminoethyl phosphorothioate, WR2721;AMifostine anhydrous;AMifostine(Ethiofos) | | CAS: | 20537-88-6 | | MF: | C5H15N2O3PS | | MW: | 214.22 | | EINECS: | 633-786-4 | | Mol File: | 20537-88-6.mol |  |
Use
Amifostine, an organic thiophosphate, was introduced for the reduction
of cisplatin-induced renal toxicity in patients with advanced ovarian cancer. It is also a
radio-protective agent. Amifostine is a prodrug which is rapidly dephosphorylated,
preferentially in non-tumor tissues to the active thiol. This agent binds to
chemotherapeutic drugs and free radicals released by radiotherapy. The protective
effect of amifostine was observed in a wide range of normal organs including bone
marrow and gastrointestinal mucosa without interfering with the anti-tumor effect of
chemohadiotherapy, indicating an increased therapeutic index for existing cancer
treatment. Amifostine is also being evaluated as a cytoprotective in other types of
tumors including lung, breast, head and neck cancers. It was reported to be a potent
mucolytic with potential in cystic fibrosis.
- Amifostine
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- US $0.00 / g
- 2021-12-14
- CAS:20537-88-6
- Min. Order: 1g
- Purity: 98.0%
- Supply Ability: 5kg/month
- Amifostine
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- US $10.00 / Kg/Bag
- 2021-10-30
- CAS:20537-88-6
- Min. Order: 1Kg/Bag
- Purity: 99%
- Supply Ability: 20 Tons
- Amifostine USP/EP/BP
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- US $1.10 / g
- 2021-08-14
- CAS:20537-88-6
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 100 Tons min
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20537-88-6
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