| | 123948-87-8 Basic information More.. |
| Product Name: | Topotecan | | Synonyms: | 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (S)-;Hycamptin;nogitecan;NSC 609699;SKF 104864;SKF-S 104864;Topotecan lactone;Hydrochloric Acid Solution, 0.02N (N/50) | | CAS: | 123948-87-8 | | MF: | C23H23N3O5 | | MW: | 421.45 | | EINECS: | 687-471-1 | | Mol File: | 123948-87-8.mol |  |
Use
Topotecan was launched in the US for the second-line treatment of ovarian
cancer. It can be prepared in four steps from camptothecin and is a water soluble
derivative of the natural product with decreased toxicity. Unlike its chemical relative
irinotecan, topotecacan in not a prodrug and does not require bioactivation. It is an
inhibitor of topoisomerase I. Specifically, it inhibits the release of topoisomerase I
from DNA, where it relaxes supercoiled DNA, giving rise to single-strand breaks.
When the replication fork reaches this complex, double-stand breaks can occur. This
signals apoptosis and eventually gives rise to cell death. Evidence indicates
hycamtin is safe for people with impaired hepatic function.
- Topotecan
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- US $50.00-50.00 / KG
- 2024-02-03
- CAS:123948-87-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 9000kg/per week
- Topotecan
-
- US $65.00 / G
- 2021-11-02
- CAS:123948-87-8
- Min. Order: 1G
- Purity: 99%
- Supply Ability: 10kgs
- Topotecan
-
- US $50.00 / KG
- 2021-10-20
- CAS:123948-87-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 9000kg/per week
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123948-87-8
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