Topotecan suppliers
Topotecan
- CAS:
- 123948-87-8
- MF:
- C23H23N3O5
- MW:
- 421.45
Certification
- DMF
- KOSHER
Suppliers by country/region
Company Type
Properties
- Melting point:
- −114 °C(lit.)
- Boiling point:
- >100 °C(lit.)
- Density
- 1.2 g/mL at 25 °C(lit.)
- vapor density
- 1.3 (vs air)
- vapor pressure
- 613 psi ( 21.1 °C)
- Flash point:
- 12 °C
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- H2O: soluble
- form
- liquid
- pka
- 8.92±0.40(Predicted)
- color
- yellow
- InChI
- InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1
- InChIKey
- UCFGDBYHRUNTLO-QHCPKHFHSA-N
- SMILES
- N1C2C(=C(CN(C)C)C(O)=CC=2)C=C2CN3C(C=12)=CC1[C@](CC)(O)C(=O)OCC=1C3=O
- CAS DataBase Reference
- 123948-87-8(CAS DataBase Reference)
Safety Information
- Symbol(GHS)
GHS08
- Signal word
- Danger
- Hazard statements
- H340-H361d
- Precautionary statements
- P201-P202-P280-P308+P313-P405-P501
- Hazard Codes
- T,C,F,Xi
- Risk Statements
- 36/37/38-67-35-20-11-34-48-46-36
- Safety Statements
- 26-45-36/37/39-37/39-36-22-24/25-16-7
- RIDADR
- UN 3286 3/PG 2
- WGK Germany
- 2
- RTECS
- MW4025000
- F
- 3
- HazardClass
- 8
- PackingGroup
- II
- Storage Class
- 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
- Hazard Classifications
- Muta. 1B
Repr. 2
- Hazardous Substances Data
- 123948-87-8(Hazardous Substances Data)
Use
Topotecan was launched in the US for the second-line treatment of ovarian cancer. It can be prepared in four steps from camptothecin and is a water soluble derivative of the natural product with decreased toxicity. Unlike its chemical relative irinotecan, topotecacan in not a prodrug and does not require bioactivation. It is an inhibitor of topoisomerase I. Specifically, it inhibits the release of topoisomerase I from DNA, where it relaxes supercoiled DNA, giving rise to single-strand breaks. When the replication fork reaches this complex, double-stand breaks can occur. This signals apoptosis and eventually gives rise to cell death. Evidence indicates hycamtin is safe for people with impaired hepatic function.
281 supplier list of "Topotecan"
- Product Name:Topotecan
- Products Intro:Purity: 99% | Package: 25KG
- Company Type: Service provider
- Country/Region: CHINA
- Product Name:TIANFU-CHEM 123948-87-8 Topotecan
- Products Intro:Purity: 99% | Package: 25KG;5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Product Name:topotecan
- Products Intro:Purity: 0.99 | Package: 1kg
- Company Type: Trader
- Country/Region: CHINA
$32.00-76.00
- Product Name:Topotecan
- Products Intro:Purity: 95.19% | Package: 5mg;32USD|10mg;45USD|25mg;76USD | CustNote: REAGENT;FOR LABORATORY USE ONLY
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Compound Libraries,Noval Small Molecucles,Nature Compounds,Inhibitory Antibodies,Life science Kits
- Product Name:(2R,8S)-2-fluoro-1,2,3,5,6,7-hexahydropyrrolizine-8-carboxylic acid;hydrochloride
- Products Intro:Package: 1g,5g,10g
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Topotecan
- Products Intro:Purity: 0.99 | Package: 25kg;1kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Bredereck's Reagent,Salicylic Acid,Amino Acids,Bipyridine Derivatives,Phenanthroline Derivatives
- Product Name:Topotecan
- Products Intro:Purity: 98% | Package: 1g,10g,25g,100g,500g,1kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 528-94-9,AMMONIUM SALICYLATE,Linolenic acid,463-40-1,931-36-2
- Product Name:Topotecan
- Products Intro:Purity: 0.99 | Package: 5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: API(Active Pharmaceutical Ingredient),Lab Fine Chemical,Phytochemistry,Cosmetic Raw Materials