117976-90-6 Basic information More..
Product Name:Rebeprazole sodium
Synonyms:Rabeprazole for system suitability;Aciphex Sodium;Habeprazole Sodium;LY307640 sodium;2-[[[4-(3-METHOXYPROPOXY)-3-METHYL-2-PYRIDINYL]METHYL]SULFINYL]-1H-BENZIMIDAZOLE, SODIUM SALT;2-[[[4-(3-METHOXYPROPOXY)-3-METHYLPYRIDIN-2-YL]METHYL]SULFINY]-1H-BENZIMIDAZOLE SODIUM SALT;rebeprazole sodium;sodium 2-[[4-(3-methoxypropoxy)-3-methyl-pyridin-2-yl]methylsulfinyl]benzoimidazole
CAS:117976-90-6
MF:C18H20N3NaO3S
MW:381.42
EINECS:629-730-3
Mol File:117976-90-6.mol
117976-90-6

Use

Rebeprazole sodium was launched as Pariet in Japan, its first market, for the treatment of peptic ulcers including gastric and duodenal ulcers. From 4-chloro- 2,3-dimethylpyridine N-oxide, a six step synthesis allows access to the basic skeleton after successive condensations. Rabeprazole, a structural analog of Omeprazole, the first compound to have been marketed in this class up to now, is reported to be a more potent inhibitor of gastric H+/K+-adenosine triphosphate (ATPase) ; a common mechanism of action of this chemical class involves the conversion at low pH to a reactive sulphonamide that itself binds to cysteine residues located on the enzyme. Moreover, rabeprazole showed an antibacterial activity against Helicobacter Pylori, with a MIC90 of 1.56 μg/ml. Rebeprazole sodium has a faster onset of action compared with omeprazole, but a shorter duration of action, being extensively and rapidly metabolized in several animal species. In clinical studies in patients with gastric ulcers, 10 and 20 mg rabeprazole sodium once-daily significantly inhibited basal and stimulated acid output. Rabeprazole is awaiting registration in the US for treatment of gastrooesophageal reflux disease (GORD) and other pathologic hypersecretory conditions including Zollinger-Ellison syndrome. Rebeprazole sodium is White Crystalline Solid Rebeprazole sodium is a partially reversible gastric proton pump inhibitor

Lastest Price from Rebeprazole sodium manufacturers

  • Rebeprazole sodium
  • US $1.00 / kg
  • 2019-07-06
  • CAS:117976-90-6
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: Customized
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