| | 4311-88-0 Basic information More.. |
| Product Name: | Necrostatin-1 | | Synonyms: | Necrostatin-1, >=98%;IFLAB-BB F0911-6127;5-(INDOL-3-YLMETHYL)-3-METHYL-2-THIO-HYDANTOIN;NECROSTATIN-1;MTH-DL-TRYPTOPHAN;MTH-DL-Tryptophan Methylthiohydantoin-DL-tryptophan;5-(1H-INDOL-3-YLMETHYL)-3-METHYL-2-THIOXO-4-IMIDAZOLIDINONE;5-(1H-Indole-3ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone | | CAS: | 4311-88-0 | | MF: | C13H13N3OS | | MW: | 259.33 | | EINECS: | 200-256-5 | | Mol File: | 4311-88-0.mol |  |
Use
Necrostatin-1 (1-100 μM) inhibits the autophosphorylation of overexpressed and endogenous RIP1.It is found RIP1 is the primary cellular target responsible for the antinecroptosis activity of Necrostatin-1. Necrostatin-1 efficiently suppresses necroptotic cell death triggered by an array of stimuli in a variety of cell types. Necrostatin-1, previously identified as small-molecule inhibitor of necroptosis, inhibits RIP kinase-induced necroptosis and inhibits TNF-α-induced necroptosis in jurkat cells with EC50 of 490 nM.
- Necrostatin-1
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- US $30.00-75.00 / mg
- 2025-11-11
- CAS:4311-88-0
- Min. Order:
- Purity: 99.57%
- Supply Ability: 10g
- Necrostatin-1
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- US $5.00 / KG
- 2019-09-04
- CAS:4311-88-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 1ton
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4311-88-0
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