Antiamoebic and anti-trichomoniasis drugs

Antiamoebic drug is mainly used for the treatment of amoebae disease caused by the dissolved tissue amoebae. Amoeba parasitize in the human intestinal in two basic forms--trophozoites and cysts. Infectious amebic cysts are contagious. After being swallowed, trophozoites broken out of the capsule, living in the intestinal life, melting tissue and penetrating into the submucosal tissue within the division of reproduction, leading to intestinal wall ulcers, and causing acute or chronic amoebic dysentery. If the environment is not suitable, the trophozoites will become cyst with thick cystic wall; excrete with the feces, and then infect the new host. Amoebic trophozoites sometimes migrate to the liver, lung and brain tissue to stay breeding with the intestinal wall blood flow, and cause liver abscess, lung abscess and brain abscess, known as parenteral amoebiasis. At present, the majority of anti-amoebic drugs can kill trophozoites; a small number of drugs kill cysts. In addition, some antibiotics such as paromomycin, oxytetracycline can kill the trophozoites or inhibit symbiotic flora to treat amibiasis.
Trichomoniasis is a disease mainly caused by trichomonas vaginitis and the vaginal flagellum trichomoniasis, which can also be parasitic in the male genitourinary tract, spreading through sexual contact. At present, metronidazole is the the most effective drugs to treat vaginal trichomoniasis, and anti-metronidazole trichomoniasis infection can also use acetyl arsenic amine, trichostatin to cure.
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Structure Chemical Name CAS MF
Metronidazole Metronidazole 443-48-1 C6H9N3O3
Ornidazole Ornidazole 16773-42-5 C7H10ClN3O3
Clioquinol Clioquinol 130-26-7 C9H5ClINO
Benzoylmetronildazole Benzoylmetronildazole 13182-89-3 C13H13N3O4
Lycorine hydrochloride Lycorine hydrochloride 2188-68-3 C16H17NO4
5,7-Diiodo-8-quinolinol 5,7-Diiodo-8-quinolinol 83-73-8 C9H5I2NO
Flubendazole Flubendazole 31430-15-6 C16H12FN3O3
Tinidazole Tinidazole 19387-91-8 C8H13N3O4S
Emetine dihydrochloride Emetine dihydrochloride 316-42-7 C29H42Cl2N2O4
LYCORINE LYCORINE 476-28-8 C16H17NO4
EMETINE HCL EMETINE HCL 14198-59-5 C29H41ClN2O4
ACETARSONE ACETARSONE 97-44-9 C8H10AsNO5
CARBARSONE CARBARSONE 121-59-5 C7H9AsN2O4
EMETINE EMETINE 483-18-1 C29H40N2O4
bialamicol bialamicol 493-75-4 C28H43N2O2
diloxanide diloxanide 579-38-4 C9H9Cl2NO2
Metronidazole DisodiuM Phosphate Metronidazole DisodiuM Phosphate
phanquone phanquone 84-12-8 C12H6N2O2
Forminitrazole Forminitrazole 500-08-3
8-Hydroxy-7-iodo-5-quinolinesulfonic acid 8-Hydroxy-7-iodo-5-quinolinesulfonic acid 8002-90-2 C9H6INO4S
tryparsamide  tryparsamide 554-72-3 C8H10AsN2O4.Na
dehydroemetine dehydroemetine 4914-30-1 C29H38N2O4
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