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| | Baxitozine Basic information |
| Product Name: | Baxitozine | | Synonyms: | Baxitozine;(E)-4-Oxo-4-(3,4,5-trimethoxyphenyl)-2-butenoic acid;RU-38086;2-Butenoic acid, 4-oxo-4-(3,4,5-trimethoxyphenyl)-, (2E)- | | CAS: | 84386-11-8 | | MF: | C13H14O6 | | MW: | 266.25 | | EINECS: | | | Product Categories: | | | Mol File: | 84386-11-8.mol |  |
| | Baxitozine Chemical Properties |
| | Baxitozine Usage And Synthesis |
| Originator | Baxitozine,ZYF Pharm Chemical | | Manufacturing Process | 29.6 g of glyoxylic acid of 50% by weight are heated in water under reduced
pressure until elimination of 80% of the water present, whereupon, after
cooling, 84.1 g of 3,4,5-trimethoxy acetophenone are introduced into the
reaction mixture. Heating is effected for 2 h at 95°-100°C under reduced
pressure (about 50 mm/Hg), at the same time distilling off the residual water
present.
After cooling of the medium, 120 ml of water containing 11.6 g of sodium
carbonate and ether are introduced, the aqueous phase is decanted and
washed with : ether, whereupon the aqueous phase is acidified to a pH of 1
with 50% hydrochloric acid. The desired product is extracted with ethyl
acetate. After elimination of the extraction solvent 31.5 g of the 4-(3,4,5-
trimethoxyphenyl)-4-oxo-2-hydroxy butanoic acid, melting point 119°-120° are obtained (recrystallization from 1,2-dichloroethane).
15.8 g of 4-(3,4,5-trimethoxyphenyl)-4-oxo-2-hydroxy butanoic acid, 20 ml of
acetic acid and 20 ml of concentrated hydrochloric acid (d-1.18) are heated
for 2.5 h under reflux. The reaction medium is cooled and precipitated by
water. The precipitate formed is filtered off. 10.5 g of the (E)-4-(3,4,5-
trimethoxyphenyl)-4-oxo-2-butenoic acid, melting point 140°C are obtained
(recrystallization from ethanol-water 1:1). | | Therapeutic Function | Gastric cytoprotective; Antiulcer |
| | Baxitozine Preparation Products And Raw materials |
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