| Company Name: |
Energy Chemical
|
| Tel: |
021-021-58432009 400-005-6266 |
| Email: |
sales8178@energy-chemical.com |
| Products Intro: |
Product Name:2′,4′,5′-TriMethoxyacetophenone
CAS:1818-28-6
Purity:97% Package:25G
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| Company Name: |
Nanjing Chemlin Chemical Co., Ltd
|
| Tel: |
025-83697070 |
| Email: |
info@chemlin.com.cn |
| Products Intro: |
Product Name:2,4,5-Trimethoxyacetophenone
CAS:1818-28-6
Purity:98% Package:5KG; 1KG
|
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| | 2',4',5'-TRIMETHOXYACETOPHENONE Basic information |
| Product Name: | 2',4',5'-TRIMETHOXYACETOPHENONE | | Synonyms: | 2',4',5'-TRIMETHOXYACETOPHENONE;2,4,5-TRIMETHOXYACETOPHENONE;1-(2,4,5-Trimethoxyphenyl)ethanone;Acetophenone, 2',4',5'-trimethoxy-;Ethanone, 1-(2,4,5-trimethoxyphenyl)-;1-(2,4,5-trimethoxyphenyl)ethan-1-one;trimethyl(1-pyrazolyl)silane;2'，4'，5'-Trimethoxyacetophenone | | CAS: | 1818-28-6 | | MF: | C11H14O4 | | MW: | 210.23 | | EINECS: | 217-333-4 | | Product Categories: | Aromatic Acetophenones & Derivatives (substituted) | | Mol File: | 1818-28-6.mol |  |
| | 2',4',5'-TRIMETHOXYACETOPHENONE Chemical Properties |
| Hazard Codes | Xi | | Risk Statements | 36 | | Safety Statements | 26 | | WGK Germany | 3 |
| | 2',4',5'-TRIMETHOXYACETOPHENONE Usage And Synthesis |
| Preparation | Preparation by reaction of acetyl chloride with hydroxyhydroquinone trimethyl ether in the presence of aluminium chloride. | | Synthesis Reference(s) | Journal of Medicinal Chemistry, 33, p. 1155, 1990 DOI: 10.1021/jm00166a012 | | Synthesis | 2,4,5-Trimethoxy acetophenone is synthesised using 2-Hydroxy-4,5-dimethoxy acetophenone as raw material by chemical reaction. The specific synthesis steps are as follows:
2-Hydroxy-4,5-dimethoxyacetophenone(5 g,0.0255 mole)
in dry acetone (100 ml)is refluxed for 30 hr under anhydrous conditions
with dimethyl sulphate (2.8 ml,3.78 g,0.03 mole)and ignited potassium
carbonate (20 g).The mixture is filtered and the inorganic residue washed
with hot acetone (2 x 20 ml).The combined acetone solution is distilled
and the oily residue macerated with crushed ice.The solid product is
filtered,washed with water and dried.It is crystallised from benzene as
colourless needles.Yield 4.5g (84.1%).M.p.97(lit.m.p.102).
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| | 2',4',5'-TRIMETHOXYACETOPHENONE Preparation Products And Raw materials |
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