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- Pre-084
-
- $716.00
-
2026-07-27
- CAS:138847-85-5
- Purity: 99.91%
- Supply Ability: 10g
|
| | PRE-084 Hydrochloride Basic information |
| Product Name: | PRE-084 Hydrochloride | | Synonyms: | 2-(4-MORPHOLINETHYL) 1-PHENYLCYCLOHEXANECARBOXYLATE HYDROCHLORIDE;PRE-084 HYDROCHLORIDE;PRE-084HCl;2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate;1-Phenylcyclohexanecarboxylic acid 2-morpholinoethyl ester;4-MeO-PBP;I-AMB;2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate | | CAS: | 138847-85-5 | | MF: | C19H27NO3 | | MW: | 317.42 | | EINECS: | | | Product Categories: | Sigma receptor;pharmaceuticals | | Mol File: | 138847-85-5.mol |  |
| | PRE-084 Hydrochloride Chemical Properties |
| Boiling point | 446.6±40.0 °C(Predicted) | | density | 1.103±0.06 g/cm3(Predicted) | | storage temp. | Store at RT | | solubility | H2O: ≤24 mg/mL | | pka | 5.99±0.10(Predicted) | | form | solid | | color | White | | Water Solubility | H2O: ≤24mg/mL | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. | | InChI | 1S/C19H27NO3.ClH/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17;/h1,3-4,7-8H,2,5-6,9-16H2;1H | | InChIKey | QUJWFJNHTBKCLU-UHFFFAOYSA-N | | SMILES | Cl.O=C(OCCN1CCOCC1)C2(CCCCC2)c3ccccc3 |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | PRE-084 Hydrochloride Usage And Synthesis |
| Description | PRE084 (138847-85-8) is an agonist of the σ receptor with selectivity for the σ1 subtype(IC50’s: σ1 = 2.2nM, σ2 = 13091nM).1PRE-084 has demonstrated neuroprotective/restorative effects in brain injury2,3and neurodegenerative conditions4-7. | | Definition | ChEBI: 1-phenyl-1-cyclohexanecarboxylic acid 2-(4-morpholinyl)ethyl ester is a member of morpholines. | | Biological Activity | High affinity, selective σ 1 agonist (K i values are 2.2 and 13091 nM for σ 1 and σ 2 receptors respectively). Selective over PCP receptors (IC 50 > 100000 nM) and several other receptor systems. Produces antiamnesic and antitussive effects in vivo . | | Biochem/physiol Actions | PRE-084 is a potent and highly selective σ1 opioid receptor agonist. It offers neuroprotection upon embolic stroke. | | storage | Store at RT | | References | [1] T P SU. Sigma compounds derived from phencyclidine: identification of PRE-084, a new, selective sigma ligand.[J]. Journal of Pharmacology and Experimental Therapeutics, 1991, 259 2: 543-550.
[2] E. GRIESMAIER . Neuroprotective effects of the sigma-1 receptor ligand PRE-084 against excitotoxic perinatal brain injury in newborn mice[J]. Experimental Neurology, 2012, 237 2: Pages 388-395. DOI:10.1016/j.expneurol.2012.06.030
[3] HUI DONG. Sigma-1 Receptor Modulates Neuroinflammation After Traumatic Brain Injury.[J]. Cellular and Molecular Neurobiology, 2016, 36 5: 639-645. DOI:10.1007/s10571-015-0244-0
[4] M.-S. GUZMÁN-LENIS C. C X Navarro. Selective sigma receptor agonist 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate (PRE084) promotes neuroprotection and neurite elongation through protein kinase C (PKC) signaling on motoneurons[J]. Neuroscience, 2009, 162 1: Pages 31-38. DOI:10.1016/j.neuroscience.2009.03.067
[5] A HYRSKYLUOTO. Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-κB pathway[J]. Cell Death & Disease, 2013, 4 5: e646-e646. DOI:10.1038/cddis.2013.170
[6] VERONICA FRANCARDO. Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism.[J]. Brain, 2014, 137 Pt 7: 1998-2014. DOI:10.1093/brain/awu107
[7] RENZO MANCUSO . Sigma-1R Agonist Improves Motor Function and Motoneuron Survival in ALS Mice[J]. Neurotherapeutics, 2012, 9 4: Pages 814-826. DOI:10.1007/s13311-012-0140-y |
| | PRE-084 Hydrochloride Preparation Products And Raw materials |
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