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| | Dehydroepiandrosterone acetate Basic information |
| | Dehydroepiandrosterone acetate Chemical Properties |
| Melting point | 168-170 °C(lit.) | | Boiling point | 407.89°C (rough estimate) | | density | 1.0998 (rough estimate) | | vapor pressure | 0Pa at 20℃ | | refractive index | 1.5192 (estimate) | | storage temp. | Refrigerator | | solubility | Chloroform, DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | White to Off-White | | Optical Rotation | [α]20/D +2.4°, c = 2 in ethanol | | Water Solubility | 11.5mg/L(temperature not stated) | | InChI | InChI=1/C21H30O3/c1-13(22)24-15-8-10-20(2)14(12-15)4-5-16-17-6-7-19(23)21(17,3)11-9-18(16)20/h4,15-18H,5-12H2,1-3H3/t15-,16-,17-,18-,20-,21-/s3 | | InChIKey | NCMZQTLCXHGLOK-KJBVPOJVSA-N | | SMILES | C[C@]12CC[C@H](OC(=O)C)CC1=CC[C@@]1([H])[C@]3([H])CCC(=O)[C@@]3(C)CC[C@]21[H] |&1:1,4,13,15,21,25,r| | | LogP | 5.1 at 20℃ | | CAS DataBase Reference | 853-23-6 |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | BV8396810 |
| | Dehydroepiandrosterone acetate Usage And Synthesis |
| Chemical Properties | Off-White Solid | | Uses | A metabolite of Dehydroepiandrosterone. This mammalian pro-hormone promotes brain and immune function | | Uses | Menopausal syndrome | | Definition | ChEBI: Prasterone acetate is a steroid ester. | | Application |
Dehydroepiandrosterone acetate (CAS No: 853-23-6, abbreviated as DHEA acetate) is an important pharmaceutical intermediate. It can be used as a raw material to produce testosterone, methyl testosterone, estradiol, and estriol. Recently, with the development of the pharmaceutical industry, more and more applications for DHEA acetate have been exploited[1].
| | Flammability and Explosibility | Not classified | | Biological Activity | Dehydroepiandrosterone acetate (DHEA, Androstenolone) is a kind of dehydroepiandrosterone derivatives. DHEA is an endogenous steroid hormone, which is considered to be a natural product/dietary supplement with many proposed benefits to humans. | | in vivo | Dehydroisoandrosterone implants increases aggression in a laboratory-based simulated territorial intrusion. Brains of Dehydroisoandrosterone-implanted birds show higher aromatase mRNA expression in the preoptic area (POA) and higher androgen receptor mRNA expression in the periventricular nucleus of the medial striatum (pvMSt) and ventromedial nucleus of the hypothalamus (VMH). The Dehydroisoandrosterone-induced increases in aromatase expression in the POA and androgen receptor expression in the pvMSt are consistent with previously reported seasonal increases in these markers associated with naturally elevated Dehydroisoandrosterone levels. Dehydroisoandrosterone supplementation (10.2 mg/kg) alone significantly increases mice body weight (BW), muscle weight, testosterone level, and glycogen contents (liver and muscle) when compared with SC group. | | References |
[1] Chao Cheng. “Solubility determination and thermodynamic models for dehydroepiandrosterone acetate in mixed solvents of (ethyl acetate + methanol), (ethyl acetate + ethanol) and (ethyl acetate + isopropanol).” Journal of Chemical Thermodynamics 101 (2016): Pages 372-379.
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| | Dehydroepiandrosterone acetate Preparation Products And Raw materials |
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