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| 化学名: | | | 英語化学名: | GNE 7915 | | 别名: | GNE 7915;[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone;GNE-7915, >=98%;(4-((4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morphol;(4-((4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone;CS-1279;GNE7915; GNE 7915;Methanone, [4-[[4-(ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinyl- | | CAS番号: | 1351761-44-8 | | 分子式: | C19H21F4N5O3 | | 分子量: | 443.4 | | EINECS: | | | カテゴリ情報: | Inhibitors;api | | Mol File: | 1351761-44-8.mol |  |
| 融点 | 143 - 144°C | | 沸点 | 629.9±65.0 °C(Predicted) | | 比重(密度) | 1.404±0.06 g/cm3(Predicted) | | 貯蔵温度 | Store at -20°C | | 溶解性 | Chloroform (Slightly), DMSO (Slightly) | | 外見 | solid | | 酸解離定数(Pka) | 2.80±0.10(Predicted) | | CAS データベース | 1351761-44-8 |
| | GNE 7915 Usage And Synthesis |
| 使用 | GNE-7915 is a Blood-Brain Barrier (BBB) penetrable small molecule inhibitor of Leucine-Rich Repeat Kinase 2 (LRRK2). | | 使用 | Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. GNE-7915 is a selective, brain-penetrable LRRK2 inhibitor (Kis = 2 and 18.7 nM in biochemical and cell-based assays, respectively). It inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation with an IC50 value of 20 nM in vivo.[Cayman Chemical] |
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