黄素腺嘌呤二核苷酸
| 中文名称 | 黄素腺嘌呤二核苷酸 |
|---|---|
| 中文同义词 | 氟-氨碇;腺嘌呤黄素二核苷酸;二核苷酸核黄素腺苷;二核苷酸黄素腺嘌呤;核黄素腺苷双核苷酸;黄素腺嘌呤二核苷酸;腺嘌呤黄素;腺[嘌呤]黃素二苷酸 |
| 英文名称 | FLAVIN ADENINE DINUCLEOTIDE |
| 英文同义词 | adenine-flavindinucleotide;adenine-flavinedinucleotide;adenine-riboflavindinuceotide;flavitan;isoalloxazine-adeninedinucleotide;riboflavin5’-(trihydrogendiphosphate),5’.fwdarw.5’-esterwithadenosine;riboflavin5’-(trihydrogendiphosphate),5’-5’-esterwithadenosine;riboflavin-adeninedinucleotide |
| CAS号 | 146-14-5 |
| 分子式 | C27H33N9O15P2 |
| 分子量 | 785.55 |
| EINECS号 | 205-663-1 |
| 相关类别 | 多核苷酸类;核酸类;生物化学品;合成材料中间体;辅酶;化工原料;Biochemistry;Vitamin Derivatives;Substrates;Vitamins;Aromatics;Bases & Related Reagents;Heterocycles;Isotope Labelled Compounds;Nucleotides;Phosphorylating and Phosphitylating Agents |
| Mol文件 | 146-14-5.mol |
| 结构式 |  |
黄素腺嘌呤二核苷酸 性质
| 密度 | 2.08±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | −20°C |
| 溶解度 | 可溶于甲醇（轻微加热）、水（轻微） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 1.13±0.50(Predicted) |
| 颜色 | 橙色 |
| Merck | 4091 |
| 稳定性 | 稳定的。与强氧化剂不相容。 |
| InChIKey | VWWQXMAJTJZDQX-ZGGJIJKNNA-N |
| CAS 数据库 | 146-14-5 |
| EPA化学物质信息 | Riboflavin 5'-(trihydrogen diphosphate), P'.fwdarw.5'-ester with adenosine (146-14-5) |
黄素腺嘌呤二核苷酸（英语：FAD），又称活性型维生素B2、核黄素-5'-腺苷二磷酸，是一种参与了重要的代谢反应的氧化还原辅酶。FAD是一种比NAD和NADP更强的氧化剂，能被1个电子或2个电子途径还原。其可用于标记黄嘌呤腺嘌呤氧化酶，核黄素激酶肿瘤坏死因子受体1 NADPH氧化酶。
|
Human Endogenous Metabolite
|
Poly(Flavin adenine dinucleotide, FAD) characterized by an additional polymer-type redox reaction is a highly effective electrocatalyst for NADH oxidation: operating at the lowest potentials reported for NADH transducers (0.00 V, pH 7.4), poly(FAD) is characterized by the electrochemical rate constant of 1.8 ± 0.6×10 -3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes are characterized by the dramatically improved stability and, is the most advantageous NADH transducers for analytical chemistry.
Flavin adenine dinucleotide (2 mg/kg, i.v.) significantly cancels chlorpromazine (CPZ)-induced decrease in ventricular fibrillation threshold (VFT). Flavin adenine dinucleotide cancels the effect of CPZ on canine heart mitochondria. After injection of Flavin adenine dinucleotide, the dogs show a transient hypotension within 10 min, then their blood pressures recover to the initial level. Flavin adenine dinucleotide also prevents mitochondrial dysfunction induced by chlorpromazine.