CGP 42112 manufacturers
- CGP 42112
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- $7.00
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2020-02-14
- CAS: 127060-75-7
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100kg
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| | CGP 42112 Basic information |
| Product Name: | CGP 42112 | | Synonyms: | [N-ALPHA-(NICOTINOYL-L-TYROSYL)-N-EPSILON-(N-ALPHA-Z-L-ARGINYL)-L-LYSYL]-L HISTIDYL-L-PROLYL-L-ISOLEUCINE;N-ALPHA-NICOTINOYL-TYR-LYS(N-ALPHA-CBZ-ARG)-HIS-PRO-ILE;N-ALPHA-NICOTINOYL-TYR-(N-ALPHA-CBZ-ARG)-LYS-HIS-PRO-ILE-OH;NICOTINOYL-TYR-LYS(CBZ-ARG)-HIS-PRO-ILE;NICOTINOYL-TYR-LYS(Z-ARG)-HIS-PRO-ILE-OH;NIC-TYR-LYS(Z-ARG)-HIS-PRO-ILE;CGP 42112;CGP-42112A | | CAS: | 127060-75-7 | | MF: | C52H69N13O11 | | MW: | 1052.19 | | EINECS: | | | Product Categories: | | | Mol File: | 127060-75-7.mol |  |
| | CGP 42112 Chemical Properties |
| density | 1.39±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO:350.0(Max Conc. mg/mL);332.64(Max Conc. mM) | | form | solid | | pka | 3.72±0.22(Predicted) | | color | white | | biological source | synthetic | | Water Solubility | Soluble to 1 mg/ml in water | | BRN | 8184948 | | InChIKey | UXGNARZDONUMMK-LRMQDCNJSA-N | | SMILES | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc3ccccc3)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)c5cccnc5)C(O)=O |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | F | 10 | | Storage Class | 11 - Combustible Solids |
| | CGP 42112 Usage And Synthesis |
| Uses | CGP-42112A has been used:
- in the isolation of RNA from fibroblast-like synoviocytes from rheumatoid arthritis patients (RA-FLS)
- to study its effects on the ERK2 phosphorylation in the cardiomyoblast cell line
- as a stimulator of angiotensin II type 2 (AT2) receptor to study its effects on human regional hemodynamic responses mediated by AT2 receptors
| | Definition | ChEBI: CGP-42112A is a hexapeptide consisting of L-tyrosine, L-lysine, L-histidine, L-proline and L-isoleucine amino acid residues coupled in sequence and in which the amino group of the L-tyrosyl residue is substituted by a (pyridin-3-ylcarbonyl)nitrilo group and in which the L-lysyl side chain amino group is substituted by a {N(2)-[(benzyloxy)carbonyl]-L-arginyl}nitrilo group. It is a potent angiotensin II receptor type 2 (AT2 receptor) agonist. It has a role as an angiotensin receptor agonist, a vasodilator agent, an antineoplastic agent, an anti-inflammatory agent and a neuroprotective agent. It is an oligopeptide, a benzyl ester and a pyridinecarboxamide. | | Biochem/physiol Actions | Potent AT2 angiotensin II receptor agonist. | | in vivo | Intravenous infusions of CGP-42112 (0.1 and 1 mg kg-1 min-1) and PD 123319 (0.36 and 1 mg kg-1 min-1) shifted the upper limit of CBF autoregulation toward higher blood pressures without affecting baseline CBF[3]. | | IC 50 | AT2 Receptor; AT1 Receptor | | storage | Store at -20°C |
| | CGP 42112 Preparation Products And Raw materials |
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