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| | Methyl 5-fluoro-2-methylbenzoate Basic information |
| Product Name: | Methyl 5-fluoro-2-methylbenzoate | | Synonyms: | RARECHEM AL BF 0505;METHYL 2-METHYL-5-FLUOROBENZOATE;5-fluoro-2-methylbenzoate;Benzoic acid, 5-fluoro-2-methyl-, methyl ester;METHYL 5-FLUORO-2-METHYLBENZOATE | | CAS: | 175278-29-2 | | MF: | C9H9FO2 | | MW: | 168.16 | | EINECS: | | | Product Categories: | | | Mol File: | 175278-29-2.mol |  |
| | Methyl 5-fluoro-2-methylbenzoate Chemical Properties |
| Boiling point | 90-92°C 15mm | | density | 1.137±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | form | liquid | | color | Brown |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | Hazard Note | Irritant | | HS Code | 2916399090 |
| | Methyl 5-fluoro-2-methylbenzoate Usage And Synthesis |
| Uses |
Methyl 5-fluoro-2-methylbenzoate was used for the preparation of derivatives of piperidinedione.
| | Synthesis | 5-Fluoro-2-methylbenzoic acid (2.3 g) was dissolved in tetrahydrofuran (THF, 50 ml). To the solution, iodomethane (0.95 ml) and N,N-diisopropylethylamine (3.2 ml) were added sequentially. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the mixture was filtered and the filtrate concentrated to give methyl 5-fluoro-2-methylbenzoate (2.3 g; 90% yield).1H-NMR (CDCl3) δ: 2.6 (s, 3H), 3.9 (s, 3H), 7.0-7.2 (m, 2H), 7.6-7.7 (m, 1H). | | References | [1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 17, p. 5286 - 5289
[2] Patent: WO2006/116157, 2006, A2. Location in patent: Page/Page column 83-84 |
| | Methyl 5-fluoro-2-methylbenzoate Preparation Products And Raw materials |
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