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| | 1-t-Boc-piperidine-4-spiro-5'-hydantoin Basic information |
| Product Name: | 1-t-Boc-piperidine-4-spiro-5'-hydantoin | | Synonyms: | 2,4-Dioxo-1,3,8-triazaspiro[4.5]decane, N8-BOC protected;tert-Butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carboxylate, 8-(tert-Butoxycarbonyl)-2,4-dioxo-1,3,8-triazaspiro[4.5]decane;8-tert-Butoxycarbonyl-1,3,8-triazaspiro[4.5]decane-2,4-dione;8-Boc-2,4-dioxo-1,3,8-triazaspiro[4.5]decane;2,4-Dioxo-1,3-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester;2,4-diketo-1,3,8-triazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester;2,4-Dioxo-1,3,8-triazaspiro[4.5]decane-8-carboxylic Acid 1,1-DiMethylethyl Ester;2,4-Dioxo-1,3,8-triazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester | | CAS: | 183673-70-3 | | MF: | C12H19N3O4 | | MW: | 269.3 | | EINECS: | | | Product Categories: | Amino Acids & Derivatives;Hydantoins & Derivatives | | Mol File: | Mol File |  |
| | 1-t-Boc-piperidine-4-spiro-5'-hydantoin Chemical Properties |
| Melting point | 242-244°C | | density | 1.28±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Dichloromethane, DMSO, Methanol | | form | Solid | | pka | 10.10±0.20(Predicted) | | color | White to Off-White | | InChI | InChI=1S/C12H19N3O4/c1-11(2,3)19-10(18)15-6-4-12(5-7-15)8(16)13-9(17)14-12/h4-7H2,1-3H3,(H2,13,14,16,17) | | InChIKey | DHJXKTPWDXJQEK-UHFFFAOYSA-N | | SMILES | N1C2(CCN(C(OC(C)(C)C)=O)CC2)C(=O)NC1=O | | CAS DataBase Reference | 183673-70-3 |
| | 1-t-Boc-piperidine-4-spiro-5'-hydantoin Usage And Synthesis |
| Chemical Properties | Off-White Powder | | Uses | A cyclic α,α-disubstituted amino acid for preparation of water-soluble highly helical peptides. | | Uses | A cyclic a,a-disubstituted amino acid for preparation of water-soluble highly helical peptides | | Synthesis | An aqueous solution (50 mL) of potassium cyanide (22.5 g, 0.335 mol) was slowly added dropwise over a period of 5 minutes to a mixture of water (90 mL) and methanol (110 mL) containing N-tert-butoxycarbonyl-4-piperidone (32.48 g, 0.1598 mol) and ammonium carbonate (33.8 g, 0.351 mol). Upon completion of the dropwise addition, an off-white precipitate rapidly appeared in the reaction mixture. Subsequently, the reaction flask was sealed and the suspension was stirred continuously at room temperature for 72 hours. Upon completion of the reaction, the light yellow precipitate was collected by filtration and washed with a small amount of water to afford 8-Boc-2,4,8-triazaspiro[4.5]decane-1,3-dione (37.1 g, 86% yield) as a colorless solid. | | References | [1] Patent: WO2009/64274, 2009, A1. Location in patent: Page/Page column 15
[2] Patent: WO2007/139813, 2007, A1. Location in patent: Page/Page column 17
[3] Patent: US2005/261322, 2005, A1. Location in patent: Page/Page column 19
[4] Bioorganic and Medicinal Chemistry Letters, 1996, vol. 6, # 22, p. 2687 - 2692 |
| | 1-t-Boc-piperidine-4-spiro-5'-hydantoin Preparation Products And Raw materials |
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