L-O-磷酸丝氨酸
中文名称 | L-O-磷酸丝氨酸 |
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中文同义词 | L-O-磷酸丝氨酸;L-2-氨基-3-羟基丙酸3-磷酸;L-丝氨酸O-磷酸;O-磷酸-L-丝氨酸;L-丝氨酸O-型磷酸;L-2-氨基-3-羟基丙酸三磷酸;L-O-磷酸丝氨酸;磷酸化丝氨酸 |
英文名称 | O-Phospho-L-serine |
英文同义词 | L-O-PHOSPHOSERINE;L-SERINE-O-PHOSPHATE;L-PHOSPHOSERINE;H-SER(PO3H2)-OH;PHOSPHATIDYLETHANOLAMINE(EGG)(RG);O-Phosho-L-serine;O-Phosphorylserine;Phospho-L-serine |
CAS号 | 407-41-0 |
分子式 | C3H8NO6P |
分子量 | 185.07 |
EINECS号 | 206-986-0 |
相关类别 | 酯;小分子抑制剂;有机化工原料;氨基酸衍生物;食品添加剂;Amino Acids;Biochemistry;Biological-modified Amino Acids;Glutamate receptor;生物化工;对照品 |
Mol文件 | 407-41-0.mol |
结构式 |
L-O-磷酸丝氨酸 性质
熔点 | 190 °C(lit.) |
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比旋光度 | [α]D20 +14~+18°(c=5,dil.HCl) |
沸点 | 475.4±55.0 °C(Predicted) |
密度 | 1.809±0.06 g/cm3(Predicted) |
蒸气压 | 0Pa at 20℃ |
储存条件 | under inert gas |
溶解度 | H2O:50 mg/mL 热,透明,无色至浅黄色 |
形态 | 结晶粉末 |
酸度系数(pKa) | pK1:2.08;pK2:5.65;pK3:9.74 (25°C) |
颜色 | 白色 |
旋光性 (optical activity) | +16.221 (2 mol dm-3 HCl) |
水溶解性 | 28.34g/L at 20℃ |
Merck | 14,7363 |
BRN | 1726826 |
InChIKey | BZQFBWGGLXLEPQ-UWTATZPHSA-N |
CAS 数据库 | 407-41-0(CAS DataBase Reference) |
Target | Value |
mGluR
() |
O-Phospho-L-serine (l-SOP) weakly binds to mGluR1, and antagonizes the effects of l-glutamate. l-SOP activates the group III receptors (mGluR4, mGluR6, mGluR7, and mGluR8), but mGluR7 has much lower affinity for l-SOP than the other group III receptors and also displays lower efficacy for both ligands. O-Phospho-L-serine (l-SOP) generates enhanced intracellular calcium responses in mGluR4 transfected cells. l-SOP inhibits the l-glutamate mediated mGluR1 response, with a K i of 1 mM; l-SOP displays a substantially more potent inhibition of mGluR2 activation, with a K i of 1 μM, three orders-of-magnitude more potent than for mGluR1. l-SOP induces membrane potential changes in HEK/TRPC4 cells transfected with mGluR4 or mGluR6. l-SOP induces TRPC4β activation mediated by Gα i/o proteins. O-Phospho-L-serine (L-SOP) inhibits Müller glia proliferation, without affecting light-induced photoreceptor cell death. L-SOP disrupts Müller glia proliferation subsequent to or in parallel with the activation of ascl1a and stat3 expression in the light-damaged retina. L-SOP inhibits cone cell regeneration in the light-damaged retina.
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