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TETRODOTOXIN

TETRODOTOXIN Suppliers list
Company Name: Kingfirst chemical (nanjing) co.,ltd
Tel: 86-25-84522992
Email: marketing@kingfirstchem.com
Products Intro: Product Name:Tetrodotoxin
CAS:4368-28-9
Purity:99.9%;99.99% Package:1mg;500mg;1g
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 008615858145714
Email: fandachem@gmail.com
Products Intro: Product Name:Tetrodotoxin
CAS:4368-28-9
Purity:As coa Package:As request Remarks:4368-28-9
Company Name: Chengdu Biopurify Phytochemicals Ltd.
Tel: 18080483897
Email: maggie@biopurify.com
Products Intro: Product Name:Tetrodotoxin
CAS:4368-28-9
Purity:90%~98% HPLC Package:20mg;100mg;500mg;1g Remarks:BP1380
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 86-18871470254
Email: linda@hubeijusheng.com
Products Intro: Product Name:Tetrodotoxin
CAS:4368-28-9
Purity:99% Package:5KG;1KG
Company Name: BOC Sciences
Tel: 1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:Tetrodotoxin
CAS:4368-28-9
Purity:98%

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TETRODOTOXIN Basic information
Description References
Product Name:TETRODOTOXIN
Synonyms:(4R,4aR,5R,7S,9S,10S,10aR,11S,12S)-2-Amino-1,4,4a,5,9,10-hexahydro-12-(hydroxymethyl)-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol|||;Tetrodotoxin&Formic acid;Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol;TETRODOTOXIN WITHOUT CITRATE BUFFER;TETRODOTOXIN WITH CITRATE BUFFER;Tetrodotoxin, citrate free;5,9:7,10a-Dimethano-10aH-1,3dioxocino6,5-dpyrimidine-4,7,10,11,12-pentol, 2-amino-1,4,4a,5,9,10-hexahydro-12-(hydroxymethyl)-, (4R,4aR,5R,7S,9S,10S,10aR,11S,12S)-;PUFFERFISHTOXIN
CAS:4368-28-9
MF:C11H17N3O8
MW:319.27
EINECS:224-458-8
Product Categories:chemical reagent;pharmaceutical intermediate;Ion Channels;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Living creature toxin;Sodium channel;Alkaloids
Mol File:4368-28-9.mol
TETRODOTOXIN Structure
TETRODOTOXIN Chemical Properties
Melting point 280 °C (decomp)
alpha D25 -8.64° (c = 8.55 in dil acetic acid)
Boiling point 458.31°C (rough estimate)
density 1.3768 (rough estimate)
refractive index 1.5700 (estimate)
storage temp. 2-8°C
solubility H2O: stable at pH 4-5 if stored frozensoluble
pka8.76 (water); 9.4 (50% alc)
form powder
color white
Merck 13,9318
CAS DataBase Reference4368-28-9(CAS DataBase Reference)
EPA Substance Registry SystemTetrodotoxin (4368-28-9)
Safety Information
Hazard Codes T+
Risk Statements 26/27/28
Safety Statements 22-36/37/39-45-36/37-28
RIDADR UN 3462 6.1/PG 1
WGK Germany 3
RTECS IO1450000
10-18
HazardClass 6.1(a)
PackingGroup I
HS Code 30029090
ToxicityLD50 i.p. in mice: 10 mg/kg (Kao, Fuhrman)
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
TETRODOTOXIN Usage And Synthesis
DescriptionTetraodotoxin is a kind of extremely potent toxin which exists in the liver and sex organs of some fishes including pufferfish, porcupine fish, ocean sunfish, and toadfish as well as some kind of amphibian, octopus and shellfish species. It is also produced by some bacteria such as Pseudomonas and Vibrio. Tetraodotoxin is extremely toxic to human, interfering with the transmission of signals of nerves to muscles and further causing paralysis of the body muscle. It can be fatal in some cases. Its mechanism of action is inhibiting the firing of action potentials in nerves through binding to the voltage-gated sodium channels in nerve cell membrane and blocking the passages of sodium ions into the nerve cell. People should wear proper protective equipment upon operations and should be subject to proper treatment upon suffering from it. However, it has been under investigation on the treatment of chronic and breakthrough pain in advanced cancer patients.
Referenceshttps://www.cdc.gov/niosh/ershdb/emergencyresponsecard_29750019.html https://en.wikipedia.org/wiki/Tetrodotoxin
Chemical Propertieswhite powder
UsesTetrodotoxin is a highly selective, reversible sodium channel blocker.
DefinitionChEBI: A quinazoline alkaloid that is a marine toxin isolated from fish such as puffer fish. It has been shown to exhibit potential neutotoxicity due to its ability to block voltage-gated sodium channels.
Biological ActivitySelective inhibitor of Na + channel conductance. Binding is reversible and of high affinity (K d = 1-10 nM). Blocks in a use-dependent manner.
Safety ProfilePoison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic fumes of Nox.
TETRODOTOXIN Preparation Products And Raw materials
Tag:TETRODOTOXIN(4368-28-9) Related Product Information
Cyanide, Quant Test Strips Potassium cyanate 11-Deoxy-11-[[2-[(4-fluoro-2-nitrophenoxy)acetylamino]ethyl]amino]tetrodotoxin,(8S)-11-Deoxy-11-[[2-[(4-fluoro-2-nitrophenoxy)acetylamino]ethyl]amino]tetrodotoxin TETRODOTOXIN (TTX) TETRODOTOXIN CITRATE,tetrodotoxin,citrate(1:1)(salt tetrodotoxin-binding protein ACONITINE TETRODOTOXIN-SENSITIV 4α-Aminocyclohexan-1α-ol 11-deoxytetrodotoxin METHYL-(TETRAHYDRO-PYRAN-3-YLMETHYL)-AMINE 1-(3-HYDROXY-6-METHOXY-2-METHYLTETRAHYDRO-2H-PYRAN-4-YL)GUANIDINE 4-(2-AMINOETHYL)TETRAHYDROPYRAN BIS(3-AMINOPROPYL) ETHER (4-AMINO-TETRAHYDRO-PYRAN-4-YL)-METHANOL 1,4-Cyclohexanedimethanol CIS-2-AMINOMETHYL-1-CYCLOHEXANOL HYDROCHLORIDE 2-Amino-2-ethyl-1,3-propanediol N-CYCLOHEXYL-GUANIDINE