Ro 41-0960 comt ihibitor

Request For Quotation
Ro 41-0960 comt ihibitor Suppliers list
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Email: info@efebio.com
Company Name: MQ (shanghai) Pharmaceuticals Co., Ltd.  
Tel: 13761635123
Email: sales@linyuepharm.com
Company Name: Shanghai Hongye Biotechnology Co. Ltd  
Tel: 400-9205774 400-920-5774
Email: sales@glpbio.cn
Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Email: sales@chemegen.com

Ro 41-0960 comt ihibitor manufacturers

  • Ro 41-0960
  • Ro 41-0960 pictures
  • $258.00
  • 2026-05-11
  • CAS:125628-97-9
  • Purity:
  • Supply Ability: 10g
Ro 41-0960 comt ihibitor Basic information
Product Name:Ro 41-0960 comt ihibitor
Synonyms:(3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)-methanon;(3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone;or1139;RO 41-0960 COMT INHIBITOR;Methanone, (3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)-;Ro 41-0960 solid;Ro 410960,Ro 41 0960;(3,4-Dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone , Ro 41-0960
CAS:125628-97-9
MF:C13H8FNO5
MW:277.2
EINECS:
Product Categories:
Mol File:125628-97-9.mol
Ro 41-0960 comt ihibitor Structure
Ro 41-0960 comt ihibitor Chemical Properties
Melting point 169-171°C
storage temp. 2-8°C
solubility H2O: <0.7 mg/mL, slightly soluble
form solid
color yellow
Water Solubility H2O: slightly soluble <0.7mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.0mg/mL
ethanol: soluble
InChI1S/C13H8FNO5/c14-9-4-2-1-3-8(9)12(17)7-5-10(15(19)20)13(18)11(16)6-7/h1-6,16,18H
InChIKeyRQPAUNZYTYHKHA-UHFFFAOYSA-N
SMILESOc1cc(cc(c1O)[N+]([O-])=O)C(=O)c2ccccc2F
Safety Information
WGK Germany 3
RTECS PC4952300
Storage Class11 - Combustible Solids
MSDS Information
Ro 41-0960 comt ihibitor Usage And Synthesis
UsesRo 41-0960 has been used as an inhibitor of catechol-O-methyl-transferase in synaptosome membrane preparations and 3T3-L1 adipocytes. It has also been used as a catechol-O-methyl-transferase inhibitor to tre at corpus striatum samples to test its effect on dopamine metabolism.
Preparationpreparation by demethylation of 2′-fluoro-4- hydroxy-3-methoxy-5-nitrobenzophenone with 48% hydrobromic acid in refluxing acetic acid for 4 h (86%).
Biological ActivityRo 41-0960 is a specific and synthetic inhibitor of the enzyme catechol-O-methyl-transferase (COMT). It binds to the catalytic site and triggers the inhibition of the methylation property of COMT. Ro 41-0960 is effective on uterine leiomyoma lesions and uterine fibroids.
Ro 41-0960 comt ihibitor Preparation Products And Raw materials
Raw materials(2-Fluorophenyl)(4-hydroxy-3-methoxy-5-nitrophenyl)methanone
Tag:Ro 41-0960 comt ihibitor(125628-97-9) Related Product Information
Ro 41-0960 comt ihibitor 1-(3,4-Dihydroxy-5-nitrophenyl)ethanone 4-ethyl-5-fluoro-2-nitrophenol 4-(4-hydroxy-3-nitrobenzoyl)-2-nitrophenol 4-Hydroxy-3-nitrobenzophenone Ethanone, 1-[4-(4-fluorophenoxy)-3-nitrophenyl]-