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Product Name:3,3′,5-Triiodo-L-thyronine sodiuM salt hydrate
CAS:345957-19-9
Purity:95% Package:100MG,250MG
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3 3' 5-TRIIODO-L-THYRONINE SODIUM SALT& manufacturers
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| | 3 3' 5-TRIIODO-L-THYRONINE SODIUM SALT& Basic information |
| | 3 3' 5-TRIIODO-L-THYRONINE SODIUM SALT& Chemical Properties |
| Melting point | 205 °C (dec.)(lit.) | | storage temp. | Store at -20°C | | solubility | DMF: 0.25 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 1 mg/ml | | form | A crystalline solid | | color | white to light pink | | Optical Rotation | [α]22/D +21.5°, c = 2 in 1 N HCl: ethanol, 1:2 |
| | 3 3' 5-TRIIODO-L-THYRONINE SODIUM SALT& Usage And Synthesis |
| Description | 3,3'',5-Triiodo-L-thyronine (T3) is a thyroid hormone. It is produced by 5''-monodeiodination of the prohormone thyroxine (T4) in various tissues, including liver and kidney. T3 is an agonist of thyroid hormone receptors TRα and TRβ (Kis = 2.3 nM for both) that modulates diverse biological properties, including metabolism, cardiac function, growth, and redox signaling. It also functions as an inhibitor of L-type amino acid transporter 1 (LAT1), inhibiting LAT1-mediated leucine uptake in HEK293 cells when used at a concentration of 10 μM. | | Uses | Liothyronine sodium hydrate is an active form of thyroid hormone. Liothyronine sodium hydrate is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[1][2][3]. | | IC 50 | Human Endogenous Metabolite | | References | [1] Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94. DOI:10.1016/0304-3835(94)90274-7
[2] Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92. DOI:10.1006/bbrc.1993.2055
[3] Hiroaki Shiohara, et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 1;20(11):3622-34. DOI:10.1016/j.bmc.2012.03.056 |
| | 3 3' 5-TRIIODO-L-THYRONINE SODIUM SALT& Preparation Products And Raw materials |
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