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| | Y-27632 DIHYDROCHLORIDE Basic information |
| Product Name: | Y-27632 DIHYDROCHLORIDE | | Synonyms: | (R)-(+)-TRANS-N-(4-PYRIDYL)-4-(1-AMINOETHYL)-CYCLOHEXANECARBOXAMIDE 2HCL;(R)-(+)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL)CYCLOHEXANECARBOXAMIDE DIHYDROCHLORIDE;(+)-R-TRANS-4-(AMINOETHYL)-N-(4-PYRIDYL)-CYCLOHEXANECARBOXAMIDE 2HCL H2O;Y-27632 DIHYDROCHLORIDE;TRANS-4-[(1R)-1-AMINOETHYL]-N-4-PYRIDINYLCYCLOHEXANECARBOXAMIDE DIHYDROCHLORIDE;4-[(1R)-1-Aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide dihydrochloride;(1R,4r)-4-((R)-1-aMinoethyl)-N-(pyridin-4-yl)cyclohexanecarboxaMide dihydrochloride;CyclohexanecarboxaMide,4-[(1R)-1-aMinoethyl]-N-4-pyridinyl-, trans- | | CAS: | 146986-50-7 | | MF: | C14H21N3O | | MW: | 247.34 | | EINECS: | 1312995-182-4 | | Product Categories: | Inhibitors;Protein Kinase;Signalling;Inhibitor;APIs;SiChem | | Mol File: | 146986-50-7.mol |  |
| | Y-27632 DIHYDROCHLORIDE Chemical Properties |
| Melting point | >260°C (dec.) | | Boiling point | 462.6±15.0 °C(Predicted) | | density | 1.136±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,2-8°C | | solubility | H2O: 14 mg/mL | | form | solid | | pka | 13.53±0.40(Predicted) | | color | white | | Stability: | Hygroscopic |
| Hazard Codes | Xn | | Risk Statements | 20/21/22 | | Safety Statements | 36 | | WGK Germany | 3 |
| | Y-27632 DIHYDROCHLORIDE Usage And Synthesis |
| Uses | Y-27632 Dihydrochloride is a salt analog of Y-27632, which is Rho-kinase inhibitor. | | Definition | ChEBI: A monocarboxylic acid amide that is trans-[(1R)-1-aminoethyl]cyclohexanecarboxamide in which one of the nitrogens of the aminocarbony group is substituted by a pyridine nucleus. It has been shown to exhibit inhibitory acti
ity against Rho-associated protein kinase (ROCK) enzyme. | | Biological Activity | Selective inhibitor of the Rho-associated protein kinase p160ROCK. K i values are 0.14, 26, 25 and >250 μ M for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase respectively. Also inhibits the protein kinase C-related protein kinase, PRK2 (IC 50 = 600nM). Smooth muscle relaxant and orally active in vivo . Increases survival rate of human embryonic stem (hES) cells undergoing cryopreservation. | | references | [1] ishizaki t1, uehata m, tamechika i, keel j, nonomura k, maekawa m, narumiya s. pharmacological properties of y-27632, a specific inhibitor of rho-associated kinases. mol pharmacol. 2000 may;57(5):976-83. |
| | Y-27632 DIHYDROCHLORIDE Preparation Products And Raw materials |
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