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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Pyridine compound >Ethylpyridine >(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide

(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide

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(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide Suppliers list
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 18871490254
Email: linda@hubeijusheng.com
Products Intro: Product Name:(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide
CAS:199433-58-4
Purity:0.99 Package:5KG;1KG
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427
Email: sales@conier.com
Products Intro: Product Name:y 33075
CAS:199433-58-4
Purity:0.99 Package:1kg
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:Y-33075；Y 39983
CAS:199433-58-4
Purity:98.00% Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；200 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-029-89586680 +86-18192503167
Email: 1026@dideu.com
Products Intro: Product Name:(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide
CAS:199433-58-4
Purity:99.0% min Package:1g;1.1USD
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Products Intro: Product Name:(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide
CAS:199433-58-4
Purity:99.00% Package:1g;1.1USD Remarks:ISO 9001：2015 REACH Approved Manufacturer

(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide manufacturers
(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide Basic information
Product Name:(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide
Synonyms:(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide;Y 33075;Y33075;Y 39983;Y 39983;Y39983;Benzamide, 4-[(1R)-1-aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-yl-;4-[(1R)-1-Aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide;(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide ISO 9001：2015 REACH;Y 33075,Y33075
CAS:199433-58-4
MF:C16H16N4O
MW:280.32
EINECS:
Product Categories:
Mol File:199433-58-4.mol
(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide Structure
(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide Chemical Properties
Boiling point 588.8±50.0 °C(Predicted)
density 1.32
storage temp. Store at -20°C
solubility DMSO : 50 mg/mL (178.37 mM; Need ultrasonic and warming)H2O : < 0.1 mg/mL (insoluble)
form Powder
pka11.13±0.20(Predicted)
Safety Information
MSDS Information
(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide Usage And Synthesis
DefinitionChEBI: 4-[(1R)-1-aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide is a pyrrolopyridine.
Biological ActivityY-33075 is a potent ROCK inhibitor derived from Y-27632, but more active with IC50 value of 3.6 nM.
in vitro

Y-33075 (Y-39983) is a potent ROCK inhibitor, with an IC 50 of 3.6 nM. It also inhibits PKC and CaMKII more potently than Y-27632, and the IC 50 s of Y-27632 and Y-33075 for PKC are 9.0 μM and 0.42 μM, respectively, whereas the IC 50 s of Y-27632 and Y- 33075 for CaMKII are 26 μM and 0.81 μM, respectively. The IC 50 s of Y-27632 and Y-33075 for PKC are 82 and 117 times those for ROCK, respectively, whereas the IC 50 s of Y-27632 and Y-33075 for CaMKII is 236 and 225 times those for ROCK, respectively. Y-33075 (Y-39983, 10 μM) extends neurites in the retinal ganglion cells (RGCs) compared with those in RGCs treated without Y-39983. It (Y-39983, 1 μM) inhibits the contraction of rabbit ciliary artery segments evoked by histamine in Ca 2+ -free solutions. Y-33075 ( 10 μM) shows no effect on the [Ca 2+ ]i increase with the high-potassium (high-K) solution.

p>
target

ROCK

3.6 nM (IC 50 )

PKC

420 nM (IC 50 )

CaMKII

810 nM (IC 50 )

(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide Preparation Products And Raw materials
Tag:(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide(199433-58-4) Related Product Information
PRND N-Ethylaniline Y27632 (hydrochloride) N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Y320 (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride Y-27632 DIHYDROCHLORIDE