|
|
| | 1-PYRIDIN-4-YLPIPERIDIN-4-ONE Basic information |
| Product Name: | 1-PYRIDIN-4-YLPIPERIDIN-4-ONE | | Synonyms: | 1-(4-Pyridinyl)-4-piperidinone;2,3,5,6-TETRAHYDRO-[1,4']BIPYRIDINYL-4-ONE;1-PYRIDIN-4-YLPIPERIDIN-4-ONE;4-Piperidinone, 1-(4-pyridinyl)-;1-pyridin-4-yl-4-piperidinone | | CAS: | 126832-81-3 | | MF: | C10H12N2O | | MW: | 176.22 | | EINECS: | | | Product Categories: | | | Mol File: | 126832-81-3.mol |  |
| | 1-PYRIDIN-4-YLPIPERIDIN-4-ONE Chemical Properties |
| Boiling point | 340.8±32.0 °C(Predicted) | | density | 1.163±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | pka | 10.54±0.10(Predicted) |
| Hazard Codes | Xn | | Risk Statements | 22 | | HS Code | 2933399990 |
| | 1-PYRIDIN-4-YLPIPERIDIN-4-ONE Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 1-(4-pyridyl)-piperidin-4-one from the compound (CAS:166954-75-2) was as follows: 79.7 g of the aforementioned ketone was dissolved in 2 L of tetrahydrofuran, followed by the addition of 1000 mL of 6 N hydrochloric acid solution. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the solvent was removed by evaporation and concentration, and the pH was adjusted to alkaline with semi-concentrated ammonia. Extraction was carried out using dichloromethane and the combined organic phases were concentrated by evaporation to give 64.2 g (quantitative yield) of 2,3,5,6-tetrahydro-[1,4']bipyridin-4-one, which has a melting point of 102 °C. | | References | [1] Patent: US2003/236266, 2003, A1. Location in patent: Page 7
[2] European Journal of Medicinal Chemistry, 2017, vol. 139, p. 128 - 152
[3] Patent: WO2010/81851, 2010, A1. Location in patent: Page/Page column 17
[4] Patent: US2012/71461, 2012, A1. Location in patent: Page/Page column 147
[5] Tetrahedron Letters, 2007, vol. 48, # 14, p. 2519 - 2525 |
| | 1-PYRIDIN-4-YLPIPERIDIN-4-ONE Preparation Products And Raw materials |
|