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Benzonitrile, 4,4'-[[2,2'-bis(hydroxymethyl)[1,1'-biphenyl]-4,4'-diyl]bis(oxy)]bis-

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Benzonitrile, 4,4'-[[2,2'-bis(hydroxymethyl)[1,1'-biphenyl]-4,4'-diyl]bis(oxy)]bis- Basic information
Product Name:Benzonitrile, 4,4'-[[2,2'-bis(hydroxymethyl)[1,1'-biphenyl]-4,4'-diyl]bis(oxy)]bis-
Synonyms:Benzonitrile, 4,4'-[[2,2'-bis(hydroxymethyl)[1,1'-biphenyl]-4,4'-diyl]bis(oxy)]bis-;4-((2,2'-bis(hydroxymethyl)-4'-(4-isocyanophenoxy)-[1,1'-biphenyl]-4-yl)oxy)benzonitrile;Crisaborole Diamer;Crisaborole Dimer ImpurityQ: What is Crisaborole Dimer Impurity Q: What is the CAS Number of Crisaborole Dimer Impurity;4,4'-((2,2'-bis(hydroxymethyl)-[1,1'-biphenyl]-4,4'-diyl)bis(oxy))dibenzonitrile
CAS:2254541-79-0
MF:C28H20N2O4
MW:448.47
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Mol File:2254541-79-0.mol
Benzonitrile, 4,4'-[[2,2'-bis(hydroxymethyl)[1,1'-biphenyl]-4,4'-diyl]bis(oxy)]bis- Structure
Benzonitrile, 4,4'-[[2,2'-bis(hydroxymethyl)[1,1'-biphenyl]-4,4'-diyl]bis(oxy)]bis- Chemical Properties
Boiling point 702.3±60.0 °C(Predicted)
density 1.37±0.1 g/cm3(Predicted)
pka13.95±0.10(Predicted)
Safety Information
MSDS Information
Benzonitrile, 4,4'-[[2,2'-bis(hydroxymethyl)[1,1'-biphenyl]-4,4'-diyl]bis(oxy)]bis- Usage And Synthesis
UsesCrisaborole Diamer Impurity is an impurity of Crisaborole (H947928). Crisaborole is a series of phenoxy benzoxaboroles were synthesized and screened for their inhibitory activity against PDE4 and cytokine release. 5-(4-Cyanophenoxy)-2,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2728) showed potent activity both in vitro and in vivo. AN2728 is being studied as an anti-inflammatory agent.
Benzonitrile, 4,4'-[[2,2'-bis(hydroxymethyl)[1,1'-biphenyl]-4,4'-diyl]bis(oxy)]bis- Preparation Products And Raw materials
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