| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
marketing1@energy-chemical.com |
ZED-1227 manufacturers
- ZED-1227
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- $261.00
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2026-08-30
- CAS:1542132-88-6
- Purity: 99.04%
- Supply Ability: 10g
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| | ZED-1227 Basic information |
| Product Name: | ZED-1227 | | Synonyms: | 2-Heptenoic acid, 7-[[1-[2-[(2-ethylbutyl)amino]-2-oxoethyl]-1,2-dihydro-2-oxo-3-pyridinyl]amino]-6-[[(1-methyl-1H-imidazol-5-yl)carbonyl]amino]-7-oxo-, methyl ester, (2E,6S)-;ZED-1227;ZED 1227,ZED1227;Methyl (S,E)-7-((1-(2-((2-ethylbutyl)amino)-2-oxoethyl)-2-oxo-1,2-dihydropyridin-3-yl)amino)-6-(1-methyl-1H-imidazole-5-carboxamido)-7-oxohept-2-enoate | | CAS: | 1542132-88-6 | | MF: | C26H36N6O6 | | MW: | 528.6 | | EINECS: | | | Product Categories: | | | Mol File: | 1542132-88-6.mol |  |
| | ZED-1227 Chemical Properties |
| Boiling point | 916.3±65.0 °C(Predicted) | | density | 1.24±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 10.63±0.20(Predicted) | | color | Off-white to light yellow |
| | ZED-1227 Usage And Synthesis |
| Uses | (2E,6S)-7-[[1-[2-[(2-Ethylbutyl)amino]-2-oxoethyl]-1,2-dihydro-2-oxo-3-pyridinyl]amino]-6-[[(1-methyl-1H-imidazol-5-yl)carbonyl]amino]-7-oxo-2-heptenoic Acid Methyl Ester is a derivative of pyridinone which serves as transglutaminase inhibitors. | | in vivo | ZED-1227 reduces the activity of intestinal TG2 induced by Polyinosinic:Polycytidylic acid (40 mg/kg) to normal control levels and subdues intestinal inflammation in mice[1].
ZED-1227 (5 mg/kg; i.g.) is able to inhibit TG2 in the small intestinal mucosa[2].
| Animal Model: | BALB/c mice[2] | | Dosage: | 5 mg/kg | | Administration: | Oral gavage | | Result: | Inhibited TG2 in vivo in the small intestinal mucosa. |
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| | ZED-1227 Preparation Products And Raw materials |
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