(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one manufacturers
- Darbufelone
-
- $37.00 / 1mg
-
2025-11-10
- CAS:139226-28-1
- Min. Order:
- Purity: 99.77%
- Supply Ability: 10g
- Darbufelone
-
- $37.00 / 1mg
-
2025-11-10
- CAS:139226-28-1
- Min. Order:
- Purity: 99.77%
- Supply Ability: 10g
|
| | (5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one Basic information |
| Product Name: | (5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one | | Synonyms: | (5z)-2-amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one;5-((z)-3,5-di-tert-butyl-4-hydroxybenzylidene)-2-imino-4-thiazolidinone;(Z)-2-AMino-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)thiazol-4(5H)-one;darbufelone;CS-490;(5Z)-2-amino-5-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]-1,3-thiazol-4-one;4(5H)-Thiazolone, 2-amino-5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-, (5Z)-;(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylide... | | CAS: | 139226-28-1 | | MF: | C18H24N2O2S | | MW: | 332.46 | | EINECS: | 1312995-182-4 | | Product Categories: | | | Mol File: | 139226-28-1.mol | ![(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one Structure](CAS/GIF/139226-28-1.gif) |
| | (5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one Chemical Properties |
| Boiling point | 448.6±55.0 °C(Predicted) | | density | 1.18±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 9.98±0.50(Predicted) | | color | White to off-white |
| | (5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one Usage And Synthesis |
| Uses | Darbufelone is a dual inhibitor of cellular PGF2α and LTB4 production. Darbufelone potently inhibits PGHS-2 (IC50= 0.19 μM) but is much less potent with PGHS-1 (IC50=20 μM). | | Biological Activity | Darbufelone is a dual inhibitor of cellular PGF2α and LTB4 production. It potently inhibits PGHS-2 (IC50=0.19 μM), but is much less potent against PGHS-1 (IC50=20 μM). | | in vivo | Darbufelone is a dual inhibitor of cellular PGF2R and LTB4 production. Darbufelone is orally active and nonulcerogenic in animal models of inflammation and arthritis. | | target | IC50: 0.19 μM (PGHS-2), 20 μM (PGHS-1) | | References | [1] Johnson AR, et al. Slow-binding inhibition of human prostaglandin endoperoxide synthase-2 with darbufelone, an isoform-selective antiinflammatory di-tert-butyl phenol. Biochemistry. 2001 Jun 26;40(25):7736-45. DOI:10.1021/bi002343f
[2] Ye X, et al. Darbufelone, a novel anti-inflammatory drug, induces growth inhibition of lung cancer cells both in vitro and in vivo. Cancer Chemother Pharmacol. 2010 Jul;66(2):277-85. DOI:10.1007/s00280-009-1161-z |
| | (5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one Preparation Products And Raw materials |
|