Darbufelone mesilate manufacturers
- Darbufelone mesylate
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- $378.00 / 25mg
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2025-11-03
- CAS:139340-56-0
- Min. Order:
- Purity: 99.92%
- Supply Ability: 10g
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| | Darbufelone mesilate Basic information |
| Product Name: | Darbufelone mesilate | | Synonyms: | CI 1004;DARBUFELONE MESILATE;(5Z)-2-Amino-5-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]-1,3-thiazol-4-one methanesulfonate;Darbufelone (mesylate);CI-1004 mesylate;Darbufelone mesylate (CI-1004 mesylate) | | CAS: | 139340-56-0 | | MF: | C19H28N2O5S2 | | MW: | 428.56 | | EINECS: | | | Product Categories: | | | Mol File: | 139340-56-0.mol |  |
| | Darbufelone mesilate Chemical Properties |
| storage temp. | 4°C, protect from light | | solubility | Soluble in DMSO | | form | Solid | | color | White to light yellow |
| | Darbufelone mesilate Usage And Synthesis |
| Uses | Anti-inflammatory; antiarthritic (dual cyclooxygenase and 5-lipoxygenase inhibitor). | | in vivo | Darbufelone is a dual inhibitor of cellular PGF2R and LTB4 production. Darbufelone is orally active and nonulcerogenic in animal models of inflammation and arthritis[1]. When mice are treated with Darbufelone at dosage of 80 mg/kg/day, the tumor volumes decrease in a time-dependent manner. In contrast, lower dose of Darbufelone (20 or 40 mg/kg/day) dos not show any significant inhibition of tumor weight. At necropsy, the tumor weight in mice treated with Darbufelone (80 mg/kg/day) is reduced by 30.2% in comparison with control group[2]. | | IC 50 | PGF2α; LTB4; PGHS-2: 0.19 μM (IC50); PGHS-1: 20 μM (IC50) |
| | Darbufelone mesilate Preparation Products And Raw materials |
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