SR27897
| 中文名称 | SR27897 |
|---|---|
| 中文同义词 | 2-(2-((4-(2-氯苯基)噻唑-2-基)氨基甲酰基)-1H-吲哚-1-基)乙酸;SR 27897(LINTITRIPT),竞争性非肽CCK 1受体拮抗剂 |
| 英文名称 | SR27897 |
| 英文同义词 | SR27897;2-[[[4-(2-Chlorophenyl)-2-thiazolyl]amino]carbonyl]-1H-indole-1-aceticacid;2-[[[4-(2-chlorophenyl)-2-thiazolyl]amino]carbonyl]-1H-indole-1-acetic acid hydrate;SR 27897 hydrate;1H-Indole-1-acetic acid,2-[[[4-(2-chlorophenyl)-2-thiazolyl]amino]carbonyl]-;{2-[4-(2-Chloro-phenyl)-thiazol-2-ylcarbamoyl]-indol-1-yl}-acetic acid;2-(2-((4-(2-Chlorophenyl)thiazol-2-yl)carbamoyl)-1H-indol-1-yl)acetic acid |
| CAS号 | 136381-85-6 |
| 分子式 | C20H14ClN3O3S |
| 分子量 | 411.86 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 136381-85-6.mol |
| 结构式 |  |
SR27897 性质
| 密度 | 1.49±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Desiccate at +4°C |
| 溶解度 | DMSO：加热至60℃时≥10mg/mL |
| 酸度系数(pKa) | 4.00±0.10(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至棕褐色 |
EC50: 6 nM (cholecystokinin (CCK1) receptor); Ki: 0.2 nM (cholecystokinin (CCK1) receptor)
In vitro, Lintitript (SR 27897) is a competitive antagonist of cholecystokinin (CCK)-stimulated amylase release in isolated rat pancreatic acini (pA
2
= 7.50) and of CCK-induced guinea pig gall bladder contractions (pA
2
= 9.57).
Lintitript produces concentration dependent inhibition of [
125
I]CCK binding to CCK1 receptor sites in the rat pancreas (IC
50
value of 0.58 nM) and also to CCK 2 sites in the guinea pig cortex (IC
2
value of 479 nM). Lintitript inhibits [
125
I]gastrin binding to gastrin receptors. Lintitript (0.5 nM) increases the dissociation constant of CCK for the CCK A receptor (K
d
= 1.8 to 7.2 nM) without modifying the maximum number of receptors (B
max
= 1800 to 1770 fmol/mg).
Lintitript (SR 27897; 1 mg/kg, i.v.) completely reverses the CCK-induced amylase secretion. Lintitript also inhibits CCK-induced gastric and gallbladder emptying in mice (ED 50 s = 3 and 72 μg/kg, respectively). Lintitript is also very active (ED 50 = 27 μg/kg p.o.) in the gall bladder emptying protocol with egg yolk as an inducer of endogenous CCK release.
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2023/01/06 | S0753 | SR27897 Lintitript | 136381-85-6 | 5mg | 4152.47元 |