| Company Name: |
Finetech Industry Limited Gold
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| Tel: |
027-87465837 19945049750 |
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sales@finetechnology-ind.com |
| Products Intro: |
Product Name:Ethyl 2-[Bis(2,2,2-trifluoroethyl)phosphono] Propionate
CAS:107905-52-2
Purity:98% Package:1g,10g,25g,500g,1kg
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:Ethyl 2-[Bis(2,2,2-trifluoroethyl)phosphono] Propionate
CAS:107905-52-2
Package:10g,1g
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| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE
CAS:107905-52-2
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| | ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE Basic information |
| Product Name: | ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE | | Synonyms: | ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE;2-[Bis(2,2,2-trifluoroethoxy)phosphinyl]propanoic Acid Ethyl Ester;Ethyl 2-(2,2,2-Trifluoroethyl Phosphono)propionate;Propanoic acid, 2-[bis(2,2,2-trifluoroethoxy)phosphinyl]-, ethyl ester;Ethyl 2-(bis(2,2,2-trifluoroethoxy)phosphoryl)propanoate | | CAS: | 107905-52-2 | | MF: | C9H13F6O5P | | MW: | 346.16 | | EINECS: | | | Product Categories: | Wittig Reagents;Miscellaneous Reagents | | Mol File: | 107905-52-2.mol | ![ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE Structure](CAS/GIF/107905-52-2.gif) |
| | ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE Chemical Properties |
| Boiling point | 115-120°C/20mmHg | | density | 1.381±0.06 g/cm3(Predicted) | | storage temp. | Refrigerator | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | | form | Oil | | color | Clear Colourless to Pale Yellow | | CAS DataBase Reference | 107905-52-2 |
| | ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE Usage And Synthesis |
| Chemical Properties | Colourless Liquid | | Uses | A wittig reagent. | | Synthesis | KHMDS (7.50 mL, 3.75 mmol, 0.5 M in toluene) was added to a solution of 18-
crown-6 (4.10 g, 15.51 mmol), THF (20 mL), and bis (2,2,2-trifluoroethyl) phosphite (1)
(0.50 mL, 3.41 mmol) by syringe in a dropwise manner at -78 ℃. Following 15 min,
ethyl 2-bromopropionate (0.40 mL, 3.08 mmol) was added to the round bottom flask and
the reaction mixture was allowed to stir for 4 hr at room temperature. Following the
standard workup procedure, the crude product was then purified by flash column
chromatography (3:1 to 2:1 hexanes:EtOAc, Rf
= 0.33 in 1:1 hexanes:EtOAc) yielding
Ethyl 2-[Bis(2,2,2-trifluoroethyl)phosphono] Propionate (112 mg, 0.33 mmol, 10.5%) as a yellow syrup. |
| | ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE Preparation Products And Raw materials |
| Raw materials | Propanoic acid, 2-[bis[(trimethylsilyl)oxy]phosphinyl]-, ethyl ester-->Propanoic acid, 2-(dichlorophosphinyl)-, ethyl ester-->2,2,2-Trifluoroethanol | | Preparation Products | Ethyl (2Z,5S,6E)-5-{[tert-Butyl(dimethyl)silyl]oxy}-2,6-dimethyl-7-(2-methyl-1,3-thiazol-4-yl)hepta-2,6-dienoate |
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