| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
|
| Tel: |
821-50328103-801 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:Macbecin I;(15R)-6,17-DideMethoxy-15-Methoxy-6-Methyl-11-O-Methyl-geldanaMycin
CAS:73341-72-7
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g |
| Company Name: |
EMMX Biotechnology LLC
|
| Tel: |
888-539-0666 |
| Email: |
info@emmx.com |
| Products Intro: |
Product Name:Macbecin I
CAS:73341-72-7
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g |
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| | macbecin I Basic information |
| Product Name: | macbecin I | | Synonyms: | macbecin I;(6S,15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methylgeldanamycin;(15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methyl-geldanamycin;Geldanamycin, 6,17-didemethoxy-15-methoxy-6-methyl-11-O-methyl-, (15R)- | | CAS: | 73341-72-7 | | MF: | C30H42N2O8 | | MW: | 558.66 | | EINECS: | | | Product Categories: | | | Mol File: | 73341-72-7.mol |  |
| | macbecin I Chemical Properties |
| Melting point | 205-206 °C(Solv: ethanol (64-17-5); water (7732-18-5)) | | Boiling point | 736.2±60.0 °C(Predicted) | | density | 1.17±0.1 g/cm3(Predicted) | | storage temp. | Desiccate at -20°C | | pka | 8.62±0.70(Predicted) |
| | macbecin I Usage And Synthesis |
| Biological Activity | Ansamycin antibiotic compound that inhibits Hsp90 activity (IC 50 = 2 μ M) by binding to the ATP-binding site. Exhibits antitumor and cytocidal activities (IC 50 ~ 0.4 μ M) by causing degradation of key oncogenic client proteins such as ErbB2 and cRaf1. Displays higher affinity and potency than geldanamycin (9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate ). |
| | macbecin I Preparation Products And Raw materials |
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