8-hydroxyloxapine

8-hydroxyloxapine Suppliers list
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 86-18871470254
Email: linda@hubeijusheng.com
Products Intro: Product Name:8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-3-ol
CAS:61443-77-4
Purity:0.99 Package:5KG;1KG
Company Name: J & K SCIENTIFIC LTD.  
Tel: 010-82848833 400-666-7788
Email: jkinfo@jkchemical.com
Products Intro: Product Name:8-Hydroxy Loxapine
CAS:61443-77-4
Package:10Mg,1Mg
Company Name: Chemsky(shanghai)International Co.,Ltd.  
Tel: 021-50135380
Email: shchemsky@sina.com
Products Intro: Product Name:8-Hydroxy Loxapine
CAS:61443-77-4
Purity:98%
Company Name: BOC Sciences  
Tel: 16314854226
Email: info@bocsci.com
Products Intro: Product Name:8-Hydroxy Loxapine
CAS:61443-77-4
Purity:> 95% Remarks:https://www.bocsci.com/product/8-hydroxy-loxapine-cas-61443-77-4-261962.html
Company Name: Shanghai Kewel Chemical Co., Ltd.  
Tel: 021-64609169 18901607656
Email: greensnown@163.com
Products Intro: Product Name:8-Hydroxy Loxapine
CAS:61443-77-4
Purity:95%-98% Package:10 mg;25 mg;50 mg
8-hydroxyloxapine Basic information
Product Name:8-hydroxyloxapine
Synonyms:8-hydroxyloxapine;2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepin-8-ol;8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-3-ol;Dibenz[b,f][1,4]oxazepin-8-ol, 2-chloro-11-(4-methyl-1-piperazinyl)-;Loxapine 8-Hydroxy Impurity
CAS:61443-77-4
MF:C18H18ClN3O2
MW:343.81
EINECS:
Product Categories:Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
Mol File:61443-77-4.mol
8-hydroxyloxapine Structure
8-hydroxyloxapine Chemical Properties
Melting point 212-215°C
storage temp. Amber Vial, -20°C Freezer, Under Inert Atmosphere
Safety Information
MSDS Information
8-hydroxyloxapine Usage And Synthesis
Description8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine , an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2. Loxapine displays high affinity for histamine, serotonin (5-HT), dopamine, and α1-adrenergic receptors (Ki values = 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A-adrenergic receptors, respectively). It reduces agitation associated with schizophrenia or bipolar disorder. 8-OH Loxapine is considered inactive as it has relatively low affinity to dopamine and 5-HT receptors compared to the parent compound, however, 8-OH loxapine inhibits [14C]5-HT uptake in vitro (IC50 = 2 μM in human platelets).
Chemical PropertiesPale Yellow Solid
UsesThe inactive
8-hydroxyloxapine Preparation Products And Raw materials
Tag:8-hydroxyloxapine(61443-77-4) Related Product Information
1-(3-CHLOROBENZYL)PIPERAZINE Amoxapine 1-(2-PHENOXYPHENYL)METHANAMINE HYDROCHLORIDE loxapine 8-METHOXY LOXAPINE 2-METHOXY-BENZAMIDINE HCL 1-(2-METHOXYBENZYL) PIPERAZINE 4-(4-Chlorophenoxy)phenol 8-hydroxyloxapine CHEMBRDG-BB 4022460 Dibenz-(b,f)-1,4-oxazephine 2-Hydroxy-benzamidine HCl