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| | elaiophylin Basic information |
| Product Name: | elaiophylin | | Synonyms: | elaiophylin;Azalomycin B;EfoMycin E;EfoMycine E;GopalaMicin;255-E, 5001B, 56-62, 846 I, SNA 4606-3, AzaloMycin B, GopalaMicin, SalboMycin;Elaiophylin (Azalomycin B);Salbomycin | | CAS: | 37318-06-2 | | MF: | C54H88O18 | | MW: | 1025.27 | | EINECS: | | | Product Categories: | | | Mol File: | 37318-06-2.mol |  |
| | elaiophylin Chemical Properties |
| Melting point | 179-182℃ | | Boiling point | 1080.5±65.0 °C(Predicted) | | density | 1.25 | | storage temp. | -20°C Freezer | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 12.18±0.70(Predicted) | | form | White to off-white solid. | | color | White to Off-White |
| | elaiophylin Usage And Synthesis |
| Uses | Elaiophylin is a macrodiolide antibiotic that can be isolated from various strains of Streptomyces. It displays in vitro anti-protozoal activity against both Plasmodium and Trypanosoma (IC50s = 370 and 460 ng/ml, respectively) and cytotoxicity against human fetal lung fibroblast MRC-5 cells (IC50 = 870 ng/ml). Elaiophylin alone has no activity against Candida, although it enhances the anti-fungal activity of rapamycin . Elaiophylin also forms stable, long-lasting ion channels in bilayer membranes that are selective for cations. | | Uses | Elaiophylin is a highly characteristic metabolite produced by Streptomyces hygroscopicus. Elaiophylin inhibits testosterone 5-reductase. Elaiophylin is synergistic with its co-metabolite, rapamycin, as an antifungal. Elaiophylin also has anthelmintic and immunosuppressive activity and inhibits NO synthesis. Elaiophylin displays broad, albeit weak, biological activity against bacteria, nematodes, protozoa and mammalian tumor cells. | | Uses | Elaiophyllin is a highly characteristic metabolite produced by Streptomyces hygroscopicus. Elaiophylin inhibits testosterone 5-reductase. Elaiophylin is synergistic with its co-metabolite, rapamycin, as an antifungal. Elaiophylin also has anthelminthic and immunosuppressive activity and inhibits NO synthesis. Elaiophylin displays broad, albeit weak, biological activity against bacteria, nematodes, protozoa and mammalian tumour cells. | | Definition | ChEBI: A macrolide that is isolated from several bacteria including Streptomyces violaceoniger and other soil actinomycetes. |
| | elaiophylin Preparation Products And Raw materials |
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