5-bromo-5'-phenyl-1,2',3,3'-tetrahydrospiro[2H-indole-3,2'-(1,3,4)-thiadiazole]-2-one

5-bromo-5'-phenyl-1,2',3,3'-tetrahydrospiro[2H-indole-3,2'-(1,3,4)-thiadiazole]-2-one Suppliers list

Company Name:	ATK CHEMICAL COMPANY LIMITED
Tel:	+undefined-21-51877795
Email:	ivan@atkchemical.com
Products Intro:	CAS:297180-15-5 Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G

Company Name:	TargetMol Chemicals Inc.
Tel:	+17819995354
Email:	marketing@targetmol.com
Products Intro:	Product Name:Lipofermata CAS:297180-15-5 Purity:99.57% Package:1mg;54USD\|5mg;128USD\|10mg;228USD Remarks:REAGENT;FOR LABORATORY USE ONLY

Company Name:	TargetMol Chemicals Inc.
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Products Intro:	Product Name:Lipofermata CAS:297180-15-5 Purity:99.57% Package:1mg;54USD\|5mg;128USD\|10mg;228USD

Company Name:	Aladdin Scientific
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Products Intro:	Product Name:Lipofermata CAS:297180-15-5 Purity:99% Package:$160.9/5mg;$280.9/10mg;$460.9/25mg;Bulk package Remarks:99%

Company Name:	Shanghai Macklin Biochemical Co.,Ltd.
Tel:	15221275939
Email:	shenlinxing@macklin.cn
Products Intro:	Product Name:Lipofermata CAS:297180-15-5 Purity:>=99% Package:5mg；25mg

5-bromo-5'-phenyl-1,2',3,3'-tetrahydrospiro[2H-indole-3,2'-(1,3,4)-thiadiazole]-2-one manufacturers

5-bromo-5'-phenyl-1,2',3,3'-tetrahydrospiro[2H-indole-3,2'-(1,3,4)-thiadiazole]-2-one Basic information

Product Name:	5-bromo-5'-phenyl-1,2',3,3'-tetrahydrospiro[2H-indole-3,2'-(1,3,4)-thiadiazole]-2-one
Synonyms:	5-bromo-5'-phenyl-1,2',3,3'-tetrahydrospiro[2H-indole-3,2'-(1,3,4)-thiadiazole]-2-one;5-bromo-5'-phenyl-3'H-spiro[indole-3,2'-[1,3,4]thiadiazol]-2(1H)-one;CB16.2 aka;Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-bromo-5'-phenyl-;5-bromo-5'-phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one;5-Bromo-5’phenylspiro[1H-indole-3,2’-3H-1,3,4-thiadiazole]-2-one;5-bromo-5'-phenyl-spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one;Lipofermata,Inhibitor,Bacterial,inhibit
CAS:	297180-15-5
MF:	C15H10BrN3OS
MW:	360.23
EINECS:
Product Categories:
Mol File:	297180-15-5.mol

5-bromo-5'-phenyl-1,2',3,3'-tetrahydrospiro[2H-indole-3,2'-(1,3,4)-thiadiazole]-2-one Chemical Properties

density	1.76±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	Soluble in DMSO (up to 20 mg/ml).
pka	0.44±0.20(Predicted)
form	solid
color	Off-white
Stability:	Stable for 1 year from date of purchase? as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

Safety Information

HS Code

2934999090

MSDS Information

5-bromo-5'-phenyl-1,2',3,3'-tetrahydrospiro[2H-indole-3,2'-(1,3,4)-thiadiazole]-2-one Usage And Synthesis

Description	Lipofermata (297180-15-5) is an inhibitor of fatty acid transport protein 2 (FATP2; IC50?= 4.84 μM).1?It does not inhibit glucose transport or the activity of long chain acyl-CoA synthetase. It prevented palmitate-mediated oxidative stress, induction of BiP and CHOP, and cell death in a dose-dependent manner in hsHepG2 and mINS-1E cells suggesting utility in preventing fatty acid-mediated cell death pathways and lipotoxic disease.2?Inhibition was specific for long and very long chain fatty acids but not medium (C6-C10) acids. Lipofermata abrogates lipid transport into melanoma cells and reduces melanoma growth and invasion.3
Uses	Lipofermata is a fatty acid transport proteins (FATPs) inhibitor.
References	1) Sandoval?et al.?(2010),?Identification and characterization of small compound inhibitors of human FATP2; Biochem. Pharmacol.?79?990 2) Ahowesso?et al.?(2015),?Chemical inhibition of fatty acid absorption and cellular uptake limits lipotoxic cell death; Biochem. Pharmacol.?98?167 3) Zhang?et al.?(2018),?Adipocyte-derived lipids mediate melanoma progression via FATP proteins; Cancer Discov.?8?1006 br />

5-bromo-5'-phenyl-1,2',3,3'-tetrahydrospiro[2H-indole-3,2'-(1,3,4)-thiadiazole]-2-one Preparation Products And Raw materials

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